AutismKB 2.0

Annotation Detail for MCM2


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Basic Information Top
Gene Symbol:MCM2 ( BM28,CCNL1,CDCL1,D3S3194,KIAA0030,MGC10606,MITOTIN,cdc19 )
Gene Full Name: minichromosome maintenance complex component 2
Band: 3q21.3
Quick LinksEntrez ID:4171; OMIM: 116945; Uniprot ID:MCM2_HUMAN; ENSEMBL ID: ENSG00000073111; HGNC ID: 6944
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst27 / 62319433
fetus77 / 564012136
neonate1 / 3109732
infant1 / 2362042
juvenile9 / 55556161
adult195 / 1939121100
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma12 / 17475686
breast (mammary gland) tumor9 / 9417895
cervical tumor16 / 34366465
chondrosarcoma9 / 82823108
colorectal tumor28 / 114246245
esophageal tumor3 / 17290173
gastrointestinal tumor14 / 119369117
germ cell tumor135 / 263845511
glioma17 / 106883159
head and neck tumor37 / 136302271
kidney tumor15 / 68959217
leukemia9 / 9584293
liver tumor7 / 9635972
lung tumor31 / 103127300
lymphoma33 / 71755459
non-neoplasia3 / 9725030
normal258 / 336030776
ovarian tumor13 / 76682169
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS53 / 125680421
prostate cancer17 / 102680165
retinoblastoma23 / 46356496
skin tumor38 / 124949304
soft tissue/muscle tissue tumor42 / 125191335
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites6 / 40015149
bladder13 / 29757436
blood10 / 12347880
bone8 / 71655111
bone marrow4 / 4880181
brain117 / 1100989106
cervix20 / 48171415
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue47 / 215722217
esophagus3 / 20209148
eye31 / 211054146
heart12 / 89626133
intestine37 / 234472157
kidney20 / 21177794
larynx4 / 24145165
liver9 / 20774343
lung39 / 336974115
lymph27 / 44270609
lymph node24 / 91610261
mammary gland11 / 15327171
mouth32 / 67052477
muscle28 / 107715259
nerve2 / 15768126
ovary41 / 102051401
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta46 / 280825163
prostate20 / 189345105
salivary gland0 / 201550 
skin40 / 210574189
spleen1 / 5395218
stomach6 / 9661962
testis78 / 330442236
thymus42 / 81131517
thyroid1 / 4747321
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord2 / 13680146
uterus21 / 23287890
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202107_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts845.3
Adipocyte4.45
AdrenalCortex4.65
Adrenalgland3.8
Amygdala4.75
Appendix4.6
AtrioventricularNode3.35
BDCA4+_DentriticCells57.45
Bonemarrow187.6
BronchialEpithelialCells5.95
CD105+_Endothelial751.85
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)82.75
CD33+_Myeloid34.3
CD34+687.45
CD4+_Tcells5.35
CD56+_NKCells52.95
CD71+_EarlyErythroid503.3
CD8+_Tcells8.6
CardiacMyocytes5.95
Caudatenucleus4.05
Cerebellum3.75
CerebellumPeduncles5.6
CiliaryGanglion3.2
CingulateCortex4.65
Colorectaladenocarcinoma281
DorsalRootGanglion3.45
FetalThyroid4.45
Fetalbrain4.45
Fetalliver37.7
Fetallung6.15
GlobusPallidus3.25
Heart5.9
Hypothalamus4.9
Kidney3.65
Leukemia_chronicMyelogenousK-56276.9
Leukemia_promyelocytic-HL-60130.3
Leukemialymphoblastic(MOLT-4)250.95
Liver5.95
Lung5.2
Lymphnode4.8
Lymphoma_burkitts(Daudi)133.85
Lymphoma_burkitts(Raji)59.1
MedullaOblongata4.1
OccipitalLobe4.05
OlfactoryBulb3.55
Ovary3.05
Pancreas3.65
PancreaticIslet4.9
ParietalLobe4.8
Pituitary6.55
Placenta37.1
Pons4.3
PrefrontalCortex5.55
Prostate6.25
Salivarygland3.95
SkeletalMuscle5.4
Skin3.45
SmoothMuscle5.1
Spinalcord4.8
SubthalamicNucleus4
SuperiorCervicalGanglion5.2
TemporalLobe4.1
Testis31.35
TestisGermCell7.85
TestisIntersitial6.7
TestisLeydigCell4.6
TestisSeminiferousTubule8.15
Thalamus4.5
Thymus107.75
Thyroid10.3
Tongue4.6
Tonsil21.15
Trachea3.85
TrigeminalGanglion6.9
Uterus5.15
UterusCorpus4.1
WholeBlood4.95
Wholebrain3.75
colon6.05
pineal_day5.68
pineal_night5.54
retina5.825
small_intestine12.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12259_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.03 ± 1.04
Basal Forebrain1.55 ± 0.22
Basal Part of Pons1.37 ± 0.44
Cerebellar Cortex2.24 ± 0.57
Cerebellar Nuclei2.01 ± 0.77
Claustrum2.58 ± 0.91
Epithalamus1.43 ± 0.62
Frontal Lobe1.6 ± 0.76
Globus Pallidus1.69 ± 0.37
Hypothalamus1.76 ± 0.72
Insula1.69 ± 0.56
Limbic Lobe1.67 ± 0.77
Mesencephalon1.81 ± 0.75
Myelencephalon1.69 ± 0.69
Occipital Lobe1.74 ± 0.76
Parietal Lobe1.62 ± 0.86
Pontine Tegmentum1.8 ± 0.79
Striatum1.44 ± 0.63
Subthalamus1.75 ± 0.61
Temporal Lobe1.59 ± 0.66
Thalamus1.63 ± 0.6
White Matter1.8 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mcm2CBCerebellum1.11
1.43
Mcm2CTXCerebral cortex0.87
0.8
Mcm2HIPHippocampal region0.99
1.17
Mcm2HPFHippocampal formation1.34
1.27
Mcm2HYHypothalamus0.08
0.06
Mcm2LSXLateral septal complex0.42
0.46
Mcm2MBMidbrain0.5
0.7
Mcm2MYMedulla0.91
1.17
Mcm2OLFOlfactory bulb3.28
2.84
Mcm2PPons1.85
1.92
Mcm2PALPallidum0.03
0.03
Mcm2RHPRetrohippocampal region1.98
1.45
Mcm2sAMYStriatum-like amygdalar nuclei0
0
Mcm2STRStriatum0.57
0.67
Mcm2STRdStriatum dorsal region0.66
0.84
Mcm2STRvStriatum ventral region0.39
0.31
Mcm2THThalamus0.25
0.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MCM2_HUMAN_2 16 2 17 AESSESFTMASSPAQR PRIDE
MCM2_HUMAN_299 9 299 307 QLHLNQLIR PRIDE
MCM2_HUMAN_494 21 494 514 GLALALFGGEPKNPGGKHKVR PRIDE
MCM2_HUMAN_624 13 624 636 CTVIAAANPIGGR PRIDE
MCM2_HUMAN_826 11 826 836 DNNELLLFILK PRIDE
MCM2_HUMAN_871 17 871 887 QINIHNLSAFYDSELFR PRIDE
PAp00001427 13 624 636 CTVIAAANPIGGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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