AutismKB 2.0

Annotation Detail for MCM4


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Basic Information Top
Gene Symbol:MCM4 ( CDC21,CDC54,MGC33310,P1-CDC21,hCdc21 )
Gene Full Name: minichromosome maintenance complex component 4
Band: 8q11.21
Quick LinksEntrez ID:4173; OMIM: 602638; Uniprot ID:MCM4_HUMAN; ENSEMBL ID: ENSG00000104738; HGNC ID: 6947
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst48 / 62319770
fetus62 / 564012109
neonate5 / 31097160
infant3 / 23620127
juvenile7 / 55556125
adult223 / 1939121115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma5 / 17475286
breast (mammary gland) tumor6 / 9417863
cervical tumor14 / 34366407
chondrosarcoma11 / 82823132
colorectal tumor21 / 114246183
esophageal tumor1 / 1729057
gastrointestinal tumor11 / 11936992
germ cell tumor85 / 263845322
glioma14 / 106883130
head and neck tumor58 / 136302425
kidney tumor12 / 68959174
leukemia20 / 95842208
liver tumor5 / 9635951
lung tumor9 / 10312787
lymphoma16 / 71755222
non-neoplasia3 / 9725030
normal304 / 336030790
ovarian tumor23 / 76682299
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer6 / 10268058
retinoblastoma8 / 46356172
skin tumor29 / 124949232
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites5 / 40015124
bladder1 / 2975733
blood8 / 12347864
bone5 / 7165569
bone marrow4 / 4880181
brain93 / 110098984
cervix18 / 48171373
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue74 / 215722343
esophagus1 / 2020949
eye14 / 21105466
heart5 / 8962655
intestine32 / 234472136
kidney21 / 21177799
larynx2 / 2414582
liver13 / 20774362
lung17 / 33697450
lymph16 / 44270361
lymph node33 / 91610360
mammary gland12 / 15327178
mouth51 / 67052760
muscle5 / 10771546
nerve0 / 157680 
ovary24 / 102051235
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta30 / 280825106
prostate5 / 18934526
salivary gland6 / 20155297
skin36 / 210574170
spleen3 / 5395255
stomach2 / 9661920
testis108 / 330442326
thymus14 / 81131172
thyroid3 / 4747363
tonsil2 / 16999117
trachea3 / 5241357
umbilical cord0 / 136800 
uterus17 / 23287872
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222036_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts597.05
Adipocyte8.4
AdrenalCortex12.75
Adrenalgland8.6
Amygdala15.55
Appendix13.55
AtrioventricularNode14.55
BDCA4+_DentriticCells11.05
Bonemarrow54.65
BronchialEpithelialCells11.75
CD105+_Endothelial334.7
CD14+_Monocytes10.2
CD19+_BCells(neg._sel.)8.9
CD33+_Myeloid15.9
CD34+147
CD4+_Tcells8.45
CD56+_NKCells11.2
CD71+_EarlyErythroid177.55
CD8+_Tcells9.1
CardiacMyocytes18.1
Caudatenucleus7.95
Cerebellum8.35
CerebellumPeduncles12.65
CiliaryGanglion8.55
CingulateCortex9.75
Colorectaladenocarcinoma278
DorsalRootGanglion8.4
FetalThyroid9.55
Fetalbrain10.7
Fetalliver88.95
Fetallung9.6
GlobusPallidus8.15
Heart18
Hypothalamus11.4
Kidney9
Leukemia_chronicMyelogenousK-56244.2
Leukemia_promyelocytic-HL-60176.75
Leukemialymphoblastic(MOLT-4)179.35
Liver14.2
Lung9.5
Lymphnode7.7
Lymphoma_burkitts(Daudi)129.9
Lymphoma_burkitts(Raji)79.6
MedullaOblongata9.7
OccipitalLobe9.85
OlfactoryBulb7.75
Ovary8.45
Pancreas11
PancreaticIslet9.6
ParietalLobe10.7
Pituitary10.8
Placenta55.05
Pons10.25
PrefrontalCortex16.55
Prostate9.65
Salivarygland8.65
SkeletalMuscle16.05
Skin13.35
SmoothMuscle10.2
Spinalcord9.25
SubthalamicNucleus12.7
SuperiorCervicalGanglion17.4
TemporalLobe9.8
Testis18.7
TestisGermCell8.15
TestisIntersitial9.7
TestisLeydigCell10.35
TestisSeminiferousTubule9.1
Thalamus10.3
Thymus48.2
Thyroid10.2
Tongue14.35
Tonsil12.25
Trachea7
TrigeminalGanglion24
Uterus6.9
UterusCorpus9.05
WholeBlood9.3
Wholebrain8.75
colon50.55
pineal_day14.34
pineal_night16.88
retina22.575
small_intestine86.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P370989
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.49 ± 0.62
Basal Forebrain5.56 ± 0.42
Basal Part of Pons5.78 ± 0.31
Cerebellar Cortex5.71 ± 0.32
Cerebellar Nuclei5.48 ± 0.55
Claustrum5.4 ± 0.52
Epithalamus5.5 ± 0.42
Frontal Lobe5.61 ± 0.36
Globus Pallidus4.85 ± 0.3
Hypothalamus5.41 ± 0.2
Insula5.64 ± 0.26
Limbic Lobe5.58 ± 0.41
Mesencephalon5.4 ± 0.43
Myelencephalon5.46 ± 0.43
Occipital Lobe5.47 ± 0.41
Parietal Lobe5.52 ± 0.38
Pontine Tegmentum5.55 ± 0.43
Striatum5.37 ± 0.36
Subthalamus5.4 ± 0.33
Temporal Lobe5.64 ± 0.37
Thalamus5.48 ± 0.36
White Matter4.61 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mcm4CBCerebellum0.4
0.72
Mcm4CTXCerebral cortex0.74
1.28
Mcm4HIPHippocampal region0.22
0.29
Mcm4HPFHippocampal formation0.22
0.25
Mcm4HYHypothalamus0.49
1.27
Mcm4LSXLateral septal complex0.34
0.41
Mcm4MBMidbrain0.29
0.58
Mcm4MYMedulla0.23
0.43
Mcm4OLFOlfactory bulb0.74
1
Mcm4PPons0.45
1.1
Mcm4PALPallidum0.39
0.91
Mcm4RHPRetrohippocampal region0.17
0.19
Mcm4sAMYStriatum-like amygdalar nuclei0.35
2.23
Mcm4STRStriatum0.51
1.04
Mcm4STRdStriatum dorsal region0.52
1.27
Mcm4STRvStriatum ventral region0.65
0.71
Mcm4THThalamus0.3
0.68
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MCM4_HUMAN_114 10 114 123 QRPDLGSAQK PRIDE
MCM4_HUMAN_150 14 150 163 LVIWGTDVNVAACK PRIDE
MCM4_HUMAN_2 9 2 10 SSPASTPSR PRIDE
MCM4_HUMAN_388 8 388 395 VNVTGIYR PRIDE
MCM4_HUMAN_401 4 401 404 VNPR PRIDE
MCM4_HUMAN_446 9 446 454 VELLKELSR PRIDE
MCM4_HUMAN_502 15 502 516 AEINILLCGDPGTSK PRIDE
MCM4_HUMAN_517 13 517 529 SQLLQYVYNLVPR PRIDE
MCM4_HUMAN_537 13 537 549 GSSAVGLTAYVMK PRIDE
MCM4_HUMAN_585 16 585 600 SVLHEVMEQQTLSIAK PRIDE
MCM4_HUMAN_611 17 611 627 TSVLAAANPIESQWNPK PRIDE
MCM4_HUMAN_644 17 644 660 FDLIFLLLDPQDEAYDR PRIDE
MCM4_HUMAN_702 17 702 718 LSEEASQALIEAYVDMR PRIDE
MCM4_HUMAN_725 8 725 732 GMVSAYPR PRIDE
MCM4_HUMAN_733 7 733 739 QLESLIR PRIDE
MCM4_HUMAN_778 18 778 795 TGIVDISILTTGMSATSR PRIDE
MCM4_HUMAN_799 8 799 806 EELAEALK PRIDE
MCM4_HUMAN_820 9 820 828 YQQLFEDIR PRIDE
MCM4_HUMAN_838 8 838 845 DMFEEALR PRIDE
MCM4_HUMAN_846 13 846 858 ALADDDFLTVTGK PRIDE
PAp00000359 10 601 610 AGIICQLNAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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