AutismKB 2.0

Annotation Detail for MCM6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MCM6 ( MCG40308,Mis5,P105MCM )
Gene Full Name: minichromosome maintenance complex component 6
Band: 2q21.3
Quick LinksEntrez ID:4175; OMIM: 601806; Uniprot ID:MCM6_HUMAN; ENSEMBL ID: ENSG00000076003; HGNC ID: 6949
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst14 / 62319224
fetus100 / 564012177
neonate5 / 31097160
infant8 / 23620338
juvenile13 / 55556233
adult201 / 1939121103
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor19 / 94178201
cervical tumor11 / 34366320
chondrosarcoma6 / 8282372
colorectal tumor17 / 114246148
esophageal tumor3 / 17290173
gastrointestinal tumor4 / 11936933
germ cell tumor81 / 263845306
glioma7 / 10688365
head and neck tumor17 / 136302124
kidney tumor4 / 6895958
leukemia10 / 95842104
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma8 / 71755111
non-neoplasia5 / 9725051
normal299 / 336030788
ovarian tumor6 / 7668278
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS28 / 125680222
prostate cancer9 / 10268087
retinoblastoma19 / 46356409
skin tumor10 / 12494980
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood20 / 123478161
bone11 / 71655153
bone marrow5 / 48801102
brain118 / 1100989107
cervix11 / 48171228
connective tissue20 / 149255133
ear2 / 16212123
embryonic tissue34 / 215722157
esophagus3 / 20209148
eye22 / 211054104
heart9 / 89626100
intestine27 / 234472115
kidney28 / 211777132
larynx1 / 2414541
liver13 / 20774362
lung9 / 33697426
lymph6 / 44270135
lymph node10 / 91610109
mammary gland22 / 153271143
mouth15 / 67052223
muscle4 / 10771537
nerve1 / 1576863
ovary8 / 10205178
pancreas14 / 21481265
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta21 / 28082574
prostate15 / 18934579
salivary gland5 / 20155248
skin18 / 21057485
spleen12 / 53952222
stomach2 / 9661920
testis85 / 330442257
thymus44 / 81131542
thyroid1 / 4747321
tonsil3 / 16999176
trachea2 / 5241338
umbilical cord0 / 136800 
uterus14 / 23287860
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201930_at
Cell line Expression level Expression bar
721_B_lymphoblasts975.25
Adipocyte17.5
AdrenalCortex12.8
Adrenalgland12.4
Amygdala16.45
Appendix15.5
AtrioventricularNode9.2
BDCA4+_DentriticCells70.3
Bonemarrow74.65
BronchialEpithelialCells36.15
CD105+_Endothelial614.5
CD14+_Monocytes11.2
CD19+_BCells(neg._sel.)13.65
CD33+_Myeloid20.6
CD34+688.4
CD4+_Tcells38
CD56+_NKCells29.8
CD71+_EarlyErythroid345.95
CD8+_Tcells26.55
CardiacMyocytes20
Caudatenucleus10.7
Cerebellum12.75
CerebellumPeduncles16.45
CiliaryGanglion8
CingulateCortex13.95
Colorectaladenocarcinoma165.3
DorsalRootGanglion11.8
FetalThyroid15.05
Fetalbrain23.85
Fetalliver108.55
Fetallung23.1
GlobusPallidus10.5
Heart18.25
Hypothalamus16.15
Kidney12.55
Leukemia_chronicMyelogenousK-562229.15
Leukemia_promyelocytic-HL-60174.45
Leukemialymphoblastic(MOLT-4)693.7
Liver19
Lung13.35
Lymphnode29.1
Lymphoma_burkitts(Daudi)627.95
Lymphoma_burkitts(Raji)29.75
MedullaOblongata13.95
OccipitalLobe14.2
OlfactoryBulb11.65
Ovary10
Pancreas16.3
PancreaticIslet15.4
ParietalLobe16.15
Pituitary13.35
Placenta16.3
Pons15
PrefrontalCortex25.55
Prostate16.8
Salivarygland12.05
SkeletalMuscle14.4
Skin10.75
SmoothMuscle17.3
Spinalcord16.9
SubthalamicNucleus11.85
SuperiorCervicalGanglion16.65
TemporalLobe10.3
Testis35.15
TestisGermCell33.65
TestisIntersitial24.75
TestisLeydigCell15.45
TestisSeminiferousTubule31.05
Thalamus14.95
Thymus175.6
Thyroid19.1
Tongue14.7
Tonsil90.6
Trachea13.45
TrigeminalGanglion14.35
Uterus23.55
UterusCorpus13.35
WholeBlood32.15
Wholebrain12.8
colon47.7
pineal_day12.34
pineal_night9.62
retina18.65
small_intestine70.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8407_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.46 ± 0.36
Basal Forebrain6.03 ± 0.38
Basal Part of Pons6.55 ± 0.31
Cerebellar Cortex6.53 ± 0.16
Cerebellar Nuclei5.61 ± 0.48
Claustrum6.24 ± 0.36
Epithalamus6.42 ± 0.34
Frontal Lobe6.27 ± 0.37
Globus Pallidus5.68 ± 0.27
Hypothalamus6.2 ± 0.41
Insula6.49 ± 0.3
Limbic Lobe6.36 ± 0.36
Mesencephalon6.03 ± 0.36
Myelencephalon6.18 ± 0.38
Occipital Lobe6.32 ± 0.26
Parietal Lobe6.07 ± 0.31
Pontine Tegmentum6.09 ± 0.49
Striatum5.65 ± 0.41
Subthalamus6.03 ± 0.17
Temporal Lobe6.21 ± 0.29
Thalamus6.13 ± 0.34
White Matter5.75 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mcm6CBCerebellum6.6
8.6
Mcm6CTXCerebral cortex3.09
2.68
Mcm6HIPHippocampal region12.75
20.93
Mcm6HPFHippocampal formation9.19
13.04
Mcm6HYHypothalamus1.85
1.47
Mcm6LSXLateral septal complex3.25
5.41
Mcm6MBMidbrain2.15
2.75
Mcm6MYMedulla2.99
3.77
Mcm6OLFOlfactory bulb5.92
4.84
Mcm6PPons3.02
4.22
Mcm6PALPallidum1.16
0.97
Mcm6RHPRetrohippocampal region3.64
3.23
Mcm6sAMYStriatum-like amygdalar nuclei3.18
2.27
Mcm6STRStriatum2.13
2.74
Mcm6STRdStriatum dorsal region1.84
2.47
Mcm6STRvStriatum ventral region1.2
1.38
Mcm6THThalamus2.29
2.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MCM6_HUMAN_1 19 1 19 MDLAAAAEPGAGSQHLEVR PRIDE
MCM6_HUMAN_270 13 270 282 VSGVDGYETEGIR PRIDE
MCM6_HUMAN_367 12 367 378 GVLLMLFGGVPK PRIDE
MCM6_HUMAN_373 15 373 387 FGGVPKTTGEGTSLR PRIDE
MCM6_HUMAN_518 12 518 529 QNINLSAPIMSR PRIDE
PAp00000278 27 230 256 AEAVESAQAGDKCDFTGTLIVVPDVSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved