AutismKB 2.0

Annotation Detail for MDK


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Basic Information Top
Gene Symbol:MDK ( FLJ27379,MK,NEGF2 )
Gene Full Name: midkine (neurite growth-promoting factor 2)
Band: 11p11.2
Quick LinksEntrez ID:4192; OMIM: 162096; Uniprot ID:MK_HUMAN; ENSEMBL ID: ENSG00000110492; HGNC ID: 6972
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body88 / 707611243
blastocyst19 / 62319304
fetus39 / 56401269
neonate3 / 3109796
infant1 / 2362042
juvenile1 / 5555617
adult107 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor15 / 94178159
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor29 / 119369242
germ cell tumor25 / 26384594
glioma8 / 10688374
head and neck tumor9 / 13630266
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor8 / 9635983
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal288 / 336030785
ovarian tumor19 / 76682247
pancreatic tumor32 / 104616305
primitive neuroectodermal tumor of the CNS23 / 125680183
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor11 / 12494988
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites3 / 4001574
bladder0 / 297570 
blood4 / 12347832
bone2 / 7165527
bone marrow0 / 488010 
brain35 / 110098931
cervix4 / 4817183
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue164 / 215722760
esophagus0 / 202090 
eye13 / 21105461
heart9 / 89626100
intestine16 / 23447268
kidney11 / 21177751
larynx1 / 2414541
liver8 / 20774338
lung18 / 33697453
lymph0 / 442700 
lymph node9 / 9161098
mammary gland18 / 153271117
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary26 / 102051254
pancreas34 / 214812158
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland3 / 16585180
placenta5 / 28082517
prostate17 / 18934589
salivary gland3 / 20155148
skin16 / 21057475
spleen2 / 5395237
stomach24 / 96619248
testis16 / 33044248
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord3 / 13680219
uterus21 / 23287890
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209035_at
Cell line Expression level Expression bar
721_B_lymphoblasts21.9
Adipocyte19.9
AdrenalCortex23.35
Adrenalgland29.4
Amygdala21.5
Appendix26.65
AtrioventricularNode18.7
BDCA4+_DentriticCells17.75
Bonemarrow24.25
BronchialEpithelialCells20.65
CD105+_Endothelial21.55
CD14+_Monocytes17.85
CD19+_BCells(neg._sel.)20.85
CD33+_Myeloid22.25
CD34+31.45
CD4+_Tcells21.3
CD56+_NKCells19.55
CD71+_EarlyErythroid18.1
CD8+_Tcells15.6
CardiacMyocytes104.3
Caudatenucleus22.05
Cerebellum19.65
CerebellumPeduncles43.4
CiliaryGanglion17.05
CingulateCortex21.5
Colorectaladenocarcinoma287.85
DorsalRootGanglion37.35
FetalThyroid22.95
Fetalbrain21.65
Fetalliver24
Fetallung93
GlobusPallidus15.1
Heart26.9
Hypothalamus20.6
Kidney17.95
Leukemia_chronicMyelogenousK-56267
Leukemia_promyelocytic-HL-6017.2
Leukemialymphoblastic(MOLT-4)17.2
Liver27.7
Lung123.25
Lymphnode24
Lymphoma_burkitts(Daudi)24.85
Lymphoma_burkitts(Raji)25.45
MedullaOblongata17.35
OccipitalLobe26.1
OlfactoryBulb38.7
Ovary141.8
Pancreas51
PancreaticIslet64.75
ParietalLobe19.15
Pituitary120.65
Placenta28.55
Pons18.4
PrefrontalCortex21.6
Prostate218.55
Salivarygland17.3
SkeletalMuscle25.4
Skin16.1
SmoothMuscle105.6
Spinalcord24.65
SubthalamicNucleus17.45
SuperiorCervicalGanglion23.85
TemporalLobe18.75
Testis16.7
TestisGermCell14.75
TestisIntersitial14.35
TestisLeydigCell20.55
TestisSeminiferousTubule23.25
Thalamus22.35
Thymus95.65
Thyroid67.15
Tongue19
Tonsil18.4
Trachea38.95
TrigeminalGanglion22.25
Uterus118.25
UterusCorpus49.95
WholeBlood19.1
Wholebrain16.35
colon27.2
pineal_day30.54
pineal_night25
retina127.45
small_intestine71.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13864_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.79 ± 0.72
Basal Forebrain5 ± 0.1
Basal Part of Pons3.64 ± 0.75
Cerebellar Cortex5.1 ± 0.43
Cerebellar Nuclei4.67 ± 0.51
Claustrum4.81 ± 0.64
Epithalamus5.23 ± 0.35
Frontal Lobe4.38 ± 0.54
Globus Pallidus5.03 ± 0.52
Hypothalamus5.43 ± 0.5
Insula4.53 ± 0.79
Limbic Lobe4.43 ± 0.63
Mesencephalon4.77 ± 0.67
Myelencephalon4.63 ± 0.56
Occipital Lobe4.29 ± 0.55
Parietal Lobe4.43 ± 0.7
Pontine Tegmentum4.56 ± 0.58
Striatum4.37 ± 0.65
Subthalamus4.3 ± 0.7
Temporal Lobe4.47 ± 0.66
Thalamus4.27 ± 0.57
White Matter4.47 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MdkCBCerebellum32.9
29.24
MdkCTXCerebral cortex6.98
4.53
MdkHIPHippocampal region10.69
5.69
MdkHPFHippocampal formation10.87
7.03
MdkHYHypothalamus3.28
2.25
MdkLSXLateral septal complex4.62
4.97
MdkMBMidbrain3.64
4.39
MdkMYMedulla7.72
6.49
MdkOLFOlfactory bulb15.81
8.75
MdkPPons5.49
4.99
MdkPALPallidum0.89
0.72
MdkRHPRetrohippocampal region10.99
8.5
MdksAMYStriatum-like amygdalar nuclei4.62
3.09
MdkSTRStriatum3.7
3.31
MdkSTRdStriatum dorsal region2.37
2.6
MdkSTRvStriatum ventral region5.03
2.98
MdkTHThalamus3.54
2.45
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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