AutismKB 2.0

Annotation Detail for ME1


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Basic Information Top
Gene Symbol:ME1 ( HUMNDME,MES )
Gene Full Name: malic enzyme 1, NADP(+)-dependent, cytosolic
Band: 6q14.2
Quick LinksEntrez ID:4199; OMIM: 154250; Uniprot ID:MAOX_HUMAN; ENSEMBL ID: ENSG00000065833; HGNC ID: 6983
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus17 / 56401230
neonate9 / 31097289
infant0 / 236200 
juvenile0 / 555560 
adult164 / 193912184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor7 / 17290404
gastrointestinal tumor3 / 11936925
germ cell tumor4 / 26384515
glioma10 / 10688393
head and neck tumor4 / 13630229
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor6 / 9635962
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal171 / 336030750
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor116 / 125191926
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood6 / 12347848
bone3 / 7165541
bone marrow1 / 4880120
brain67 / 110098960
cervix2 / 4817141
connective tissue130 / 149255870
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus7 / 20209346
eye6 / 21105428
heart1 / 8962611
intestine12 / 23447251
kidney13 / 21177761
larynx0 / 241450 
liver11 / 20774352
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth7 / 67052104
muscle4 / 10771537
nerve0 / 157680 
ovary1 / 1020519
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta2 / 2808257
prostate10 / 18934552
salivary gland0 / 201550 
skin20 / 21057494
spleen2 / 5395237
stomach4 / 9661941
testis24 / 33044272
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204058_at
Cell line Expression level Expression bar
721_B_lymphoblasts45.85
Adipocyte618.6
AdrenalCortex28.55
Adrenalgland20.85
Amygdala72.1
Appendix18.85
AtrioventricularNode17.75
BDCA4+_DentriticCells9.05
Bonemarrow12.45
BronchialEpithelialCells45.4
CD105+_Endothelial11.2
CD14+_Monocytes13.35
CD19+_BCells(neg._sel.)11.15
CD33+_Myeloid14.45
CD34+11.45
CD4+_Tcells9.25
CD56+_NKCells11.45
CD71+_EarlyErythroid10.95
CD8+_Tcells8.15
CardiacMyocytes30
Caudatenucleus14.85
Cerebellum10.45
CerebellumPeduncles15.4
CiliaryGanglion18.45
CingulateCortex12.7
Colorectaladenocarcinoma22.85
DorsalRootGanglion18.9
FetalThyroid15.2
Fetalbrain10.45
Fetalliver10.5
Fetallung8.55
GlobusPallidus13.3
Heart24.85
Hypothalamus48.55
Kidney10.3
Leukemia_chronicMyelogenousK-56211.05
Leukemia_promyelocytic-HL-609.95
Leukemialymphoblastic(MOLT-4)7.5
Liver22.45
Lung12.25
Lymphnode8.9
Lymphoma_burkitts(Daudi)15.1
Lymphoma_burkitts(Raji)19.25
MedullaOblongata11.7
OccipitalLobe13
OlfactoryBulb30.45
Ovary11.55
Pancreas12.35
PancreaticIslet12.75
ParietalLobe14.9
Pituitary29.8
Placenta9.7
Pons11.75
PrefrontalCortex25.65
Prostate13.25
Salivarygland10.25
SkeletalMuscle25.4
Skin16.1
SmoothMuscle16.05
Spinalcord42.2
SubthalamicNucleus12.75
SuperiorCervicalGanglion64.35
TemporalLobe13.4
Testis14.65
TestisGermCell30.75
TestisIntersitial14.2
TestisLeydigCell14.85
TestisSeminiferousTubule10.15
Thalamus15.55
Thymus7.7
Thyroid22.4
Tongue22.55
Tonsil11.25
Trachea9.9
TrigeminalGanglion21.75
Uterus9.6
UterusCorpus18.25
WholeBlood12.2
Wholebrain16.9
colon26.7
pineal_day251.12
pineal_night198.98
retina64.975
small_intestine35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P8196
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.9 ± 0.55
Basal Forebrain6.14 ± 0.28
Basal Part of Pons5.9 ± 0.2
Cerebellar Cortex5.53 ± 0.33
Cerebellar Nuclei6.02 ± 0.34
Claustrum5.76 ± 0.76
Epithalamus5.86 ± 0.51
Frontal Lobe6.26 ± 0.4
Globus Pallidus6.91 ± 0.14
Hypothalamus6.63 ± 0.25
Insula6.28 ± 0.32
Limbic Lobe5.82 ± 0.49
Mesencephalon6.32 ± 0.47
Myelencephalon6.05 ± 0.52
Occipital Lobe5.35 ± 0.46
Parietal Lobe6.06 ± 0.38
Pontine Tegmentum6.08 ± 0.54
Striatum6.06 ± 0.42
Subthalamus6.46 ± 0.18
Temporal Lobe6.05 ± 0.35
Thalamus6.15 ± 0.39
White Matter6.48 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mod1CBCerebellum9.24
11.24
Mod1CTXCerebral cortex1.02
0.67
Mod1HIPHippocampal region5.07
4.37
Mod1HPFHippocampal formation3.59
2.67
Mod1HYHypothalamus0.44
0.19
Mod1LSXLateral septal complex0.27
0.19
Mod1MBMidbrain0.8
0.5
Mod1MYMedulla4
2.75
Mod1OLFOlfactory bulb0.68
0.34
Mod1PPons3.87
3.83
Mod1PALPallidum0.53
0.26
Mod1RHPRetrohippocampal region1.33
0.63
Mod1sAMYStriatum-like amygdalar nuclei0.27
0.16
Mod1STRStriatum0.35
0.33
Mod1STRdStriatum dorsal region0.24
0.3
Mod1STRvStriatum ventral region0.67
0.49
Mod1THThalamus2.58
2.15
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MAOX_HUMAN_1 7 1 7 MEPEAPR PRIDE
MAOX_HUMAN_354 9 354 362 FAHEHEEMK PRIDE
MAOX_HUMAN_471 27 471 497 QITDNIFLTTAEVIAQQVSDKHLEEGR PRIDE
MAOX_HUMAN_472 21 472 492 QITDNIFLTTAEVIAQQVSDK PRIDE
PAp00008906 19 236 254 YGMNCLIQFEDFANVNAFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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