AutismKB 2.0

Annotation Detail for MAP3K4


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Basic Information Top
Gene Symbol:MAP3K4 ( FLJ42439,KIAA0213,MAPKKK4,MEKK4,MTK1,PRO0412 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 4
Band: 6q26
Quick LinksEntrez ID:4216; OMIM: 602425; Uniprot ID:M3K4_HUMAN; ENSEMBL ID: ENSG00000085511; HGNC ID: 6856
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor8 / 13630258
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal117 / 336030734
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood2 / 12347816
bone5 / 7165569
bone marrow0 / 488010 
brain45 / 110098940
cervix1 / 4817120
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye7 / 21105433
heart2 / 8962622
intestine8 / 23447234
kidney8 / 21177737
larynx2 / 2414582
liver3 / 20774314
lung7 / 33697420
lymph2 / 4427045
lymph node3 / 9161032
mammary gland9 / 15327158
mouth2 / 6705229
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid2 / 2053997
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta8 / 28082528
prostate9 / 18934547
salivary gland1 / 2015549
skin2 / 2105749
spleen1 / 5395218
stomach3 / 9661931
testis12 / 33044236
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204089_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts78.4
Adipocyte6.45
AdrenalCortex6.95
Adrenalgland6.35
Amygdala11.45
Appendix9.25
AtrioventricularNode6.4
BDCA4+_DentriticCells13.5
Bonemarrow9.05
BronchialEpithelialCells11.55
CD105+_Endothelial43.8
CD14+_Monocytes14.65
CD19+_BCells(neg._sel.)22.1
CD33+_Myeloid20
CD34+43.35
CD4+_Tcells50.2
CD56+_NKCells20.35
CD71+_EarlyErythroid15.1
CD8+_Tcells52.2
CardiacMyocytes10.85
Caudatenucleus6.35
Cerebellum6.65
CerebellumPeduncles8.85
CiliaryGanglion6.1
CingulateCortex7.7
Colorectaladenocarcinoma8.75
DorsalRootGanglion6.65
FetalThyroid9.1
Fetalbrain11.35
Fetalliver8.05
Fetallung10.05
GlobusPallidus4.75
Heart9.05
Hypothalamus10.55
Kidney6.15
Leukemia_chronicMyelogenousK-56220.9
Leukemia_promyelocytic-HL-608.25
Leukemialymphoblastic(MOLT-4)8.45
Liver10
Lung10.3
Lymphnode8.55
Lymphoma_burkitts(Daudi)11.2
Lymphoma_burkitts(Raji)11.55
MedullaOblongata8.55
OccipitalLobe7.75
OlfactoryBulb15.65
Ovary5.55
Pancreas7.4
PancreaticIslet10.2
ParietalLobe8.45
Pituitary11.8
Placenta9.8
Pons7.7
PrefrontalCortex20.4
Prostate13.75
Salivarygland8.85
SkeletalMuscle8.55
Skin5.7
SmoothMuscle9.85
Spinalcord10.1
SubthalamicNucleus7.1
SuperiorCervicalGanglion9.9
TemporalLobe7.4
Testis8.05
TestisGermCell12.5
TestisIntersitial7.95
TestisLeydigCell8.35
TestisSeminiferousTubule8.95
Thalamus7.95
Thymus11.5
Thyroid16.2
Tongue9.05
Tonsil9.1
Trachea7.3
TrigeminalGanglion8.95
Uterus22.95
UterusCorpus8.3
WholeBlood10.4
Wholebrain8.1
colon9.4
pineal_day14.12
pineal_night11.6
retina11.3
small_intestine9.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7611_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.98 ± 0.4
Basal Forebrain4.68 ± 0.18
Basal Part of Pons4.78 ± 0.5
Cerebellar Cortex5.19 ± 0.23
Cerebellar Nuclei4.59 ± 0.48
Claustrum5.08 ± 0.51
Epithalamus4.55 ± 0.45
Frontal Lobe4.75 ± 0.37
Globus Pallidus4.57 ± 0.38
Hypothalamus4.9 ± 0.37
Insula4.75 ± 0.32
Limbic Lobe4.99 ± 0.48
Mesencephalon4.87 ± 0.43
Myelencephalon4.82 ± 0.42
Occipital Lobe5.02 ± 0.36
Parietal Lobe4.93 ± 0.38
Pontine Tegmentum4.96 ± 0.48
Striatum4.48 ± 0.48
Subthalamus4.96 ± 0.2
Temporal Lobe4.97 ± 0.39
Thalamus4.89 ± 0.41
White Matter4.94 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k4CBCerebellum44.94
57.27
Map3k4CTXCerebral cortex71.57
50.81
Map3k4HIPHippocampal region86.58
100
Map3k4HPFHippocampal formation83.96
100
Map3k4HYHypothalamus61.28
47.7
Map3k4LSXLateral septal complex53.15
35.78
Map3k4MBMidbrain69.97
62.55
Map3k4MYMedulla67.05
74.29
Map3k4OLFOlfactory bulb73.55
61.21
Map3k4PPons67.91
69.88
Map3k4PALPallidum53.48
44.4
Map3k4RHPRetrohippocampal region77.35
60.79
Map3k4sAMYStriatum-like amygdalar nuclei38.34
24.54
Map3k4STRStriatum38.66
25.99
Map3k4STRdStriatum dorsal region34.33
23.55
Map3k4STRvStriatum ventral region46.45
29.56
Map3k4THThalamus69.68
56.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069224 13 520 532 HCLTSIYRPFVDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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