AutismKB 2.0

Annotation Detail for MAP3K5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP3K5 ( ASK1,MAPKKK5,MEKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 5
Band: 6q23.3
Quick LinksEntrez ID:4217; OMIM: 602448; Uniprot ID:M3K5_HUMAN; ENSEMBL ID: ENSG00000197442; HGNC ID: 6857
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult61 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal91 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland2 / 3319760
ascites1 / 4001524
bladder2 / 2975767
blood0 / 1234780 
bone2 / 7165527
bone marrow2 / 4880140
brain27 / 110098924
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye9 / 21105442
heart2 / 8962622
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver5 / 20774324
lung15 / 33697444
lymph0 / 442700 
lymph node10 / 91610109
mammary gland2 / 15327113
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary3 / 10205129
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate12 / 18934563
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach3 / 9661931
testis4 / 33044212
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203837_at
Cell line Expression level Expression bar
721_B_lymphoblasts51.6
Adipocyte7.05
AdrenalCortex43.25
Adrenalgland88.4
Amygdala75.1
Appendix10.9
AtrioventricularNode9.25
BDCA4+_DentriticCells23.1
Bonemarrow10.4
BronchialEpithelialCells7.05
CD105+_Endothelial36.65
CD14+_Monocytes56.4
CD19+_BCells(neg._sel.)15.8
CD33+_Myeloid84.05
CD34+67.55
CD4+_Tcells24.55
CD56+_NKCells16.35
CD71+_EarlyErythroid8.5
CD8+_Tcells16.05
CardiacMyocytes11.9
Caudatenucleus13.3
Cerebellum8.55
CerebellumPeduncles13.3
CiliaryGanglion9.55
CingulateCortex11.45
Colorectaladenocarcinoma8.05
DorsalRootGanglion8.95
FetalThyroid10.3
Fetalbrain12.9
Fetalliver6.45
Fetallung8.1
GlobusPallidus9.05
Heart12.05
Hypothalamus15.6
Kidney8.6
Leukemia_chronicMyelogenousK-5629.05
Leukemia_promyelocytic-HL-6013.35
Leukemialymphoblastic(MOLT-4)7.35
Liver11.25
Lung11.15
Lymphnode16.75
Lymphoma_burkitts(Daudi)12.3
Lymphoma_burkitts(Raji)20.6
MedullaOblongata11.85
OccipitalLobe11.9
OlfactoryBulb7.9
Ovary39.95
Pancreas11.8
PancreaticIslet16.65
ParietalLobe11.6
Pituitary21.15
Placenta9.5
Pons10.3
PrefrontalCortex36.95
Prostate52.75
Salivarygland8.45
SkeletalMuscle12.2
Skin8.9
SmoothMuscle8.65
Spinalcord12.25
SubthalamicNucleus9.7
SuperiorCervicalGanglion13.75
TemporalLobe9.7
Testis10
TestisGermCell8.55
TestisIntersitial8.7
TestisLeydigCell10.7
TestisSeminiferousTubule11.7
Thalamus10.75
Thymus8.1
Thyroid44.2
Tongue10.7
Tonsil10.25
Trachea8.6
TrigeminalGanglion12.8
Uterus26.45
UterusCorpus9.5
WholeBlood89.45
Wholebrain23.2
colon11.35
pineal_day116.98
pineal_night83.08
retina17.45
small_intestine13.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15295_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.63 ± 0.22
Basal Forebrain8.22 ± 0.36
Basal Part of Pons7.38 ± 0.27
Cerebellar Cortex8.22 ± 0.2
Cerebellar Nuclei7.39 ± 0.34
Claustrum8.14 ± 0.27
Epithalamus8.24 ± 0.39
Frontal Lobe8.12 ± 0.29
Globus Pallidus8.87 ± 0.41
Hypothalamus8.4 ± 0.34
Insula8.34 ± 0.25
Limbic Lobe8.29 ± 0.31
Mesencephalon8.37 ± 0.46
Myelencephalon8.23 ± 0.44
Occipital Lobe8.77 ± 0.46
Parietal Lobe8.18 ± 0.34
Pontine Tegmentum8.4 ± 0.26
Striatum8.97 ± 0.34
Subthalamus7.32 ± 0.46
Temporal Lobe8.2 ± 0.3
Thalamus8.26 ± 0.39
White Matter6.58 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k5CBCerebellum19.29
22.8
Map3k5CTXCerebral cortex73.86
61.13
Map3k5HIPHippocampal region15.59
19.33
Map3k5HPFHippocampal formation21.12
23.26
Map3k5HYHypothalamus6.53
5.78
Map3k5LSXLateral septal complex3.3
2.38
Map3k5MBMidbrain2.77
2.62
Map3k5MYMedulla3.2
3.34
Map3k5OLFOlfactory bulb25.87
23.09
Map3k5PPons1.25
1.51
Map3k5PALPallidum4.04
3.3
Map3k5RHPRetrohippocampal region28.9
27.51
Map3k5sAMYStriatum-like amygdalar nuclei15.31
11.96
Map3k5STRStriatum11.95
9.12
Map3k5STRdStriatum dorsal region7.97
6
Map3k5STRvStriatum ventral region26.88
19.25
Map3k5THThalamus35.7
34.72
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00871417 10 323 332 DIQDYDSIVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved