AutismKB 2.0

Annotation Detail for MEST


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Basic Information Top
Gene Symbol:MEST ( DKFZp686L18234,MGC111102,MGC8703,PEG1 )
Gene Full Name: mesoderm specific transcript homolog (mouse)
Band: 7q32.2
Quick LinksEntrez ID:4232; OMIM: 601029; Uniprot ID:MEST_HUMAN; ENSEMBL ID: ENSG00000106484; HGNC ID: 7028
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body37 / 70761522
blastocyst17 / 62319272
fetus118 / 564012209
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult298 / 1939121153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor8 / 34366232
chondrosarcoma5 / 8282360
colorectal tumor9 / 11424678
esophageal tumor8 / 17290462
gastrointestinal tumor8 / 11936967
germ cell tumor110 / 263845416
glioma14 / 106883130
head and neck tumor0 / 1363020 
kidney tumor9 / 68959130
leukemia7 / 9584273
liver tumor7 / 9635972
lung tumor8 / 10312777
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal494 / 3360307147
ovarian tumor12 / 76682156
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer6 / 10268058
retinoblastoma9 / 46356194
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor32 / 125191255
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland7 / 33197210
ascites1 / 4001524
bladder4 / 29757134
blood2 / 12347816
bone4 / 7165555
bone marrow7 / 48801143
brain71 / 110098964
cervix12 / 48171249
connective tissue5 / 14925533
ear4 / 16212246
embryonic tissue79 / 215722366
esophagus8 / 20209395
eye19 / 21105490
heart50 / 89626557
intestine17 / 23447272
kidney23 / 211777108
larynx0 / 241450 
liver8 / 20774338
lung39 / 336974115
lymph1 / 4427022
lymph node1 / 9161010
mammary gland6 / 15327139
mouth1 / 6705214
muscle33 / 107715306
nerve6 / 15768380
ovary14 / 102051137
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta131 / 280825466
prostate6 / 18934531
salivary gland0 / 201550 
skin9 / 21057442
spleen9 / 53952166
stomach7 / 9661972
testis74 / 330442223
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord1 / 1368073
uterus12 / 23287851
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202016_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.8
Adipocyte18.1
AdrenalCortex101.4
Adrenalgland89.6
Amygdala62.05
Appendix29.3
AtrioventricularNode21.45
BDCA4+_DentriticCells6.05
Bonemarrow27.15
BronchialEpithelialCells16.15
CD105+_Endothelial53.35
CD14+_Monocytes6.55
CD19+_BCells(neg._sel.)6.7
CD33+_Myeloid7.05
CD34+447.2
CD4+_Tcells11.05
CD56+_NKCells5.55
CD71+_EarlyErythroid5.3
CD8+_Tcells27.2
CardiacMyocytes674.95
Caudatenucleus12.1
Cerebellum10.95
CerebellumPeduncles8
CiliaryGanglion50.6
CingulateCortex55.5
Colorectaladenocarcinoma165.65
DorsalRootGanglion13.35
FetalThyroid102.45
Fetalbrain121.35
Fetalliver109.6
Fetallung635
GlobusPallidus19.8
Heart20.3
Hypothalamus37.75
Kidney21.85
Leukemia_chronicMyelogenousK-562148.35
Leukemia_promyelocytic-HL-606.9
Leukemialymphoblastic(MOLT-4)5.55
Liver40.4
Lung22.85
Lymphnode10.6
Lymphoma_burkitts(Daudi)30.95
Lymphoma_burkitts(Raji)7.1
MedullaOblongata49.35
OccipitalLobe62.85
OlfactoryBulb66.4
Ovary16.6
Pancreas68.5
PancreaticIslet100.85
ParietalLobe34.3
Pituitary148.7
Placenta1999.45
Pons27.45
PrefrontalCortex149.45
Prostate24.5
Salivarygland25.25
SkeletalMuscle7.7
Skin12.35
SmoothMuscle239.65
Spinalcord22.45
SubthalamicNucleus50.65
SuperiorCervicalGanglion33.05
TemporalLobe52.85
Testis51
TestisGermCell51.15
TestisIntersitial29.7
TestisLeydigCell57.15
TestisSeminiferousTubule29.25
Thalamus16.55
Thymus33.05
Thyroid20.65
Tongue10.9
Tonsil6.65
Trachea15.25
TrigeminalGanglion28.8
Uterus33.65
UterusCorpus17.15
WholeBlood8.7
Wholebrain28.2
colon171.25
pineal_day250.92
pineal_night190.94
retina55.275
small_intestine186.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P156970
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.59 ± 0.25
Basal Forebrain7.56 ± 0.16
Basal Part of Pons7.37 ± 0.28
Cerebellar Cortex6.3 ± 0.3
Cerebellar Nuclei6.57 ± 0.3
Claustrum7.07 ± 0.34
Epithalamus6.49 ± 0.3
Frontal Lobe6.97 ± 0.42
Globus Pallidus6.54 ± 1
Hypothalamus7.9 ± 0.58
Insula7.13 ± 0.2
Limbic Lobe7.13 ± 0.48
Mesencephalon7.06 ± 0.82
Myelencephalon6.85 ± 0.6
Occipital Lobe6.72 ± 0.59
Parietal Lobe7.06 ± 0.45
Pontine Tegmentum6.8 ± 0.51
Striatum6.62 ± 0.81
Subthalamus6.9 ± 0.69
Temporal Lobe7.17 ± 0.4
Thalamus6.5 ± 0.44
White Matter5.36 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MestCBCerebellum6.79
8.83
MestCTXCerebral cortex97.65
94.43
MestHIPHippocampal region22.5
30.56
MestHPFHippocampal formation36.47
42.77
MestHYHypothalamus94.41
93.38
MestLSXLateral septal complex100
100
MestMBMidbrain48.86
47.89
MestMYMedulla50.65
67.95
MestOLFOlfactory bulb71.2
75.61
MestPPons54.11
69.04
MestPALPallidum96.45
100
MestRHPRetrohippocampal region56.15
55.35
MestsAMYStriatum-like amygdalar nuclei100
100
MestSTRStriatum60.52
56.71
MestSTRdStriatum dorsal region27.23
23.37
MestSTRvStriatum ventral region95.76
82.64
MestTHThalamus28.9
27.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00762747 18 241 258 NNDGNLVIDSLLQYINQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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