AutismKB 2.0

Annotation Detail for MET


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Basic Information Top
Gene Symbol:MET ( AUTS9,HGFR,RCCP2,c-Met )
Gene Full Name: met proto-oncogene (hepatocyte growth factor receptor)
Band: 7q31
Quick LinksEntrez ID:4233; OMIM: 164860; Uniprot ID:MET_HUMAN; ENSEMBL ID: ENSG00000105976; HGNC ID: 7029
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus57 / 564012101
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma9 / 82823108
colorectal tumor23 / 114246201
esophageal tumor5 / 17290289
gastrointestinal tumor22 / 119369184
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor11 / 13630280
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor12 / 96359124
lung tumor9 / 10312787
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal162 / 336030748
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites16 / 40015399
bladder1 / 2975733
blood0 / 1234780 
bone6 / 7165583
bone marrow3 / 4880161
brain16 / 110098914
cervix2 / 4817141
connective tissue6 / 14925540
ear3 / 16212185
embryonic tissue1 / 2157224
esophagus5 / 20209247
eye9 / 21105442
heart1 / 8962611
intestine29 / 234472123
kidney23 / 211777108
larynx0 / 241450 
liver14 / 20774367
lung29 / 33697486
lymph0 / 442700 
lymph node5 / 9161054
mammary gland6 / 15327139
mouth6 / 6705289
muscle6 / 10771555
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate3 / 18934515
salivary gland2 / 2015599
skin12 / 21057456
spleen1 / 5395218
stomach6 / 9661962
testis3 / 3304429
thymus3 / 8113136
thyroid6 / 47473126
tonsil0 / 169990 
trachea12 / 52413228
umbilical cord0 / 136800 
uterus14 / 23287860
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211599_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.7
Adipocyte3.7
AdrenalCortex3.75
Adrenalgland3.1
Amygdala3.95
Appendix3.65
AtrioventricularNode2.75
BDCA4+_DentriticCells4.1
Bonemarrow3.65
BronchialEpithelialCells5.55
CD105+_Endothelial3.7
CD14+_Monocytes4.05
CD19+_BCells(neg._sel.)4
CD33+_Myeloid4.75
CD34+4.75
CD4+_Tcells4.1
CD56+_NKCells4.4
CD71+_EarlyErythroid3.45
CD8+_Tcells3.6
CardiacMyocytes4.6
Caudatenucleus3.3
Cerebellum3
CerebellumPeduncles4.15
CiliaryGanglion2.55
CingulateCortex3.75
Colorectaladenocarcinoma3.8
DorsalRootGanglion2.75
FetalThyroid3.6
Fetalbrain3.75
Fetalliver3.15
Fetallung3.15
GlobusPallidus2.7
Heart4.65
Hypothalamus4
Kidney3
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)2.95
Liver4.95
Lung4.05
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.7
Lymphoma_burkitts(Raji)5.1
MedullaOblongata3.4
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.45
Pancreas2.95
PancreaticIslet3.95
ParietalLobe3.85
Pituitary4.35
Placenta3.9
Pons3.5
PrefrontalCortex4.65
Prostate4.4
Salivarygland2.9
SkeletalMuscle4.3
Skin2.8
SmoothMuscle4.2
Spinalcord3.95
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.1
TemporalLobe3.35
Testis3.2
TestisGermCell3.15
TestisIntersitial3.1
TestisLeydigCell3.65
TestisSeminiferousTubule3.2
Thalamus3.75
Thymus2.95
Thyroid4.8
Tongue3.6
Tonsil3.6
Trachea3.5
TrigeminalGanglion3.65
Uterus3.05
UterusCorpus4
WholeBlood4.1
Wholebrain3.2
colon3.75
pineal_day4.62
pineal_night4.52
retina4.55
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P145846
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.29 ± 0.54
Basal Forebrain6.87 ± 1.01
Basal Part of Pons4.94 ± 0.91
Cerebellar Cortex5.14 ± 0.93
Cerebellar Nuclei6.21 ± 0.81
Claustrum4.61 ± 0.95
Epithalamus4.93 ± 0.57
Frontal Lobe4.94 ± 0.92
Globus Pallidus5.78 ± 0.75
Hypothalamus5.2 ± 0.66
Insula5.85 ± 0.82
Limbic Lobe6.45 ± 1.45
Mesencephalon5.65 ± 0.62
Myelencephalon6.06 ± 1.25
Occipital Lobe7.68 ± 0.51
Parietal Lobe6.49 ± 0.81
Pontine Tegmentum6.22 ± 1.15
Striatum4.85 ± 1.39
Subthalamus5.45 ± 1
Temporal Lobe7.1 ± 0.6
Thalamus5.5 ± 0.78
White Matter6.29 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MetCBCerebellum2.56
3.08
MetCTXCerebral cortex5.6
4.7
MetHIPHippocampal region1.09
1.29
MetHPFHippocampal formation1.86
1.99
MetHYHypothalamus0.43
0.67
MetLSXLateral septal complex5.25
4.73
MetMBMidbrain0.57
0.67
MetMYMedulla2.74
2.81
MetOLFOlfactory bulb5.89
6.88
MetPPons3.98
5.57
MetPALPallidum0.14
0.15
MetRHPRetrohippocampal region3.08
2.68
MetsAMYStriatum-like amygdalar nuclei2.39
2.24
MetSTRStriatum1.03
1.04
MetSTRdStriatum dorsal region0.78
0.87
MetSTRvStriatum ventral region0.77
0.7
MetTHThalamus0.72
0.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096835 22 899 920 SCENIHLHSEAVLCTVPNDLLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018