AutismKB 2.0

Annotation Detail for MGMT


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Basic Information Top
Gene Symbol:MGMT ( - )
Gene Full Name: O-6-methylguanine-DNA methyltransferase
Band: 10q26.3
Quick LinksEntrez ID:4255; OMIM: 156569; Uniprot ID:B4DEE8_HUMAN; ENSEMBL ID: ENSG00000170430; HGNC ID: 7059
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia1 / 9725010
normal79 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood4 / 12347832
bone1 / 7165513
bone marrow0 / 488010 
brain18 / 110098916
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye8 / 21105437
heart2 / 8962622
intestine6 / 23447225
kidney9 / 21177742
larynx0 / 241450 
liver1 / 2077434
lung10 / 33697429
lymph3 / 4427067
lymph node0 / 916100 
mammary gland3 / 15327119
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary8 / 10205178
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate6 / 18934531
salivary gland0 / 201550 
skin3 / 21057414
spleen3 / 5395255
stomach7 / 9661972
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204880_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.45
Adipocyte10.1
AdrenalCortex10.95
Adrenalgland8.75
Amygdala7.95
Appendix10.35
AtrioventricularNode7.7
BDCA4+_DentriticCells13.25
Bonemarrow10.5
BronchialEpithelialCells11.85
CD105+_Endothelial12.35
CD14+_Monocytes11.85
CD19+_BCells(neg._sel.)21.15
CD33+_Myeloid12.8
CD34+19.4
CD4+_Tcells11.6
CD56+_NKCells24.45
CD71+_EarlyErythroid8.9
CD8+_Tcells10.3
CardiacMyocytes12
Caudatenucleus9.35
Cerebellum8.4
CerebellumPeduncles21.8
CiliaryGanglion7.15
CingulateCortex10.6
Colorectaladenocarcinoma8.05
DorsalRootGanglion7.85
FetalThyroid11.05
Fetalbrain10.1
Fetalliver12.45
Fetallung12.15
GlobusPallidus7.5
Heart57.95
Hypothalamus11.55
Kidney13.3
Leukemia_chronicMyelogenousK-5628.4
Leukemia_promyelocytic-HL-6012.4
Leukemialymphoblastic(MOLT-4)11.15
Liver333.2
Lung11.8
Lymphnode9.15
Lymphoma_burkitts(Daudi)15.7
Lymphoma_burkitts(Raji)14.4
MedullaOblongata9.55
OccipitalLobe8.7
OlfactoryBulb8.25
Ovary6.3
Pancreas14
PancreaticIslet11.2
ParietalLobe10.95
Pituitary12.35
Placenta9.8
Pons9.9
PrefrontalCortex12.45
Prostate21.2
Salivarygland6.95
SkeletalMuscle12.15
Skin7.9
SmoothMuscle13.65
Spinalcord11.2
SubthalamicNucleus9.4
SuperiorCervicalGanglion11.5
TemporalLobe9.5
Testis11.2
TestisGermCell10.3
TestisIntersitial8.45
TestisLeydigCell10.25
TestisSeminiferousTubule10.85
Thalamus14.6
Thymus9.85
Thyroid13.3
Tongue10.1
Tonsil10.2
Trachea8.75
TrigeminalGanglion10.1
Uterus8.3
UterusCorpus9
WholeBlood8.35
Wholebrain9.05
colon10.6
pineal_day13.08
pineal_night12.86
retina13.175
small_intestine10.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15456_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.43 ± 0.49
Basal Forebrain5.35 ± 0.27
Basal Part of Pons5.57 ± 0.34
Cerebellar Cortex5.14 ± 0.39
Cerebellar Nuclei5.27 ± 0.42
Claustrum4.96 ± 0.74
Epithalamus5.67 ± 0.33
Frontal Lobe5.21 ± 0.45
Globus Pallidus5.88 ± 0.25
Hypothalamus5.2 ± 0.44
Insula5.3 ± 0.34
Limbic Lobe5.07 ± 0.47
Mesencephalon5.15 ± 0.45
Myelencephalon5.18 ± 0.41
Occipital Lobe4.88 ± 0.36
Parietal Lobe5.06 ± 0.4
Pontine Tegmentum5.09 ± 0.46
Striatum5.11 ± 0.34
Subthalamus4.79 ± 0.23
Temporal Lobe5.25 ± 0.39
Thalamus5.15 ± 0.33
White Matter5.9 ± 0.18
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MGMT_HUMAN_175 18 175 192 LGKPGLGGSSGLAGAWLK PRIDE
PAp00007995 23 41 63 TTLDSPLGKLELSGCEQGLHEIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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