AutismKB 2.0

Annotation Detail for MGP


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Basic Information Top
Gene Symbol:MGP ( MGLAP,NTI )
Gene Full Name: matrix Gla protein
Band: 12p12.3
Quick LinksEntrez ID:4256; OMIM: 154870; Uniprot ID:MGP_HUMAN; ENSEMBL ID: ENSG00000111341; HGNC ID: 7060
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus25 / 56401244
neonate20 / 31097643
infant3 / 23620127
juvenile1 / 5555617
adult207 / 1939121106
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor28 / 94178297
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor16 / 119369134
germ cell tumor3 / 26384511
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor18 / 68959261
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia16 / 97250164
normal458 / 3360307136
ovarian tumor1 / 7668213
pancreatic tumor23 / 104616219
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland6 / 33197180
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone3 / 7165541
bone marrow0 / 488010 
brain70 / 110098963
cervix1 / 4817120
connective tissue50 / 149255334
ear7 / 16212431
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye70 / 211054331
heart30 / 89626334
intestine9 / 23447238
kidney21 / 21177799
larynx2 / 2414582
liver2 / 2077439
lung14 / 33697441
lymph0 / 442700 
lymph node6 / 9161065
mammary gland47 / 153271306
mouth1 / 6705214
muscle12 / 107715111
nerve1 / 1576863
ovary5 / 10205148
pancreas34 / 214812158
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland6 / 16585361
placenta8 / 28082528
prostate35 / 189345184
salivary gland1 / 2015549
skin2 / 2105749
spleen0 / 539520 
stomach12 / 96619124
testis9 / 33044227
thymus3 / 8113136
thyroid6 / 47473126
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord20 / 136801461
uterus19 / 23287881
vascular138 / 517802665
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202291_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.1
Adipocyte7489.65
AdrenalCortex2209.25
Adrenalgland2496.8
Amygdala14.7
Appendix6132.7
AtrioventricularNode1992.9
BDCA4+_DentriticCells11.75
Bonemarrow12.2
BronchialEpithelialCells9.45
CD105+_Endothelial8
CD14+_Monocytes5.85
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid10.65
CD34+7.25
CD4+_Tcells8.6
CD56+_NKCells12.6
CD71+_EarlyErythroid7.15
CD8+_Tcells8.85
CardiacMyocytes3769.55
Caudatenucleus13
Cerebellum8.35
CerebellumPeduncles12.55
CiliaryGanglion2288.45
CingulateCortex19.45
Colorectaladenocarcinoma9.1
DorsalRootGanglion1026.45
FetalThyroid5349.65
Fetalbrain8.8
Fetalliver12.25
Fetallung756.3
GlobusPallidus8.75
Heart283.1
Hypothalamus130
Kidney375.9
Leukemia_chronicMyelogenousK-5629.4
Leukemia_promyelocytic-HL-606.85
Leukemialymphoblastic(MOLT-4)8.4
Liver35.45
Lung1477.1
Lymphnode925.35
Lymphoma_burkitts(Daudi)10.05
Lymphoma_burkitts(Raji)11.6
MedullaOblongata9.65
OccipitalLobe28.35
OlfactoryBulb748.75
Ovary3166.45
Pancreas556.8
PancreaticIslet640
ParietalLobe14.35
Pituitary887.75
Placenta281.05
Pons36.5
PrefrontalCortex32.8
Prostate771.95
Salivarygland1977.2
SkeletalMuscle32
Skin707.9
SmoothMuscle905.65
Spinalcord385.1
SubthalamicNucleus11.2
SuperiorCervicalGanglion982.4
TemporalLobe14.65
Testis363.6
TestisGermCell2209.4
TestisIntersitial880.75
TestisLeydigCell1378.85
TestisSeminiferousTubule708.1
Thalamus28
Thymus253.4
Thyroid1718.5
Tongue1377.25
Tonsil82.1
Trachea1612.5
TrigeminalGanglion2704.45
Uterus2719.4
UterusCorpus2300.6
WholeBlood16.15
Wholebrain15.65
colon1200.75
pineal_day287.02
pineal_night365.84
retina4571.5
small_intestine1077.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P210193
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.84 ± 0.95
Basal Forebrain2.39 ± 0.27
Basal Part of Pons2.12 ± 0.48
Cerebellar Cortex2.21 ± 0.73
Cerebellar Nuclei2.89 ± 0.59
Claustrum3.02 ± 0.61
Epithalamus2.64 ± 0.45
Frontal Lobe2.36 ± 0.75
Globus Pallidus3.2 ± 0.54
Hypothalamus2.49 ± 0.42
Insula2.54 ± 0.51
Limbic Lobe2.48 ± 0.73
Mesencephalon2.7 ± 0.65
Myelencephalon2.62 ± 0.69
Occipital Lobe2.78 ± 0.67
Parietal Lobe2.49 ± 0.67
Pontine Tegmentum2.66 ± 0.83
Striatum2.74 ± 0.66
Subthalamus2.8 ± 0.34
Temporal Lobe2.69 ± 0.8
Thalamus2.41 ± 0.72
White Matter2.81 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MgpCBCerebellum2.57
6.5
MgpCTXCerebral cortex1.4
2.16
MgpHIPHippocampal region1.91
3.93
MgpHPFHippocampal formation1.93
3.47
MgpHYHypothalamus1.45
2.63
MgpLSXLateral septal complex1.89
2.64
MgpMBMidbrain4.3
9.13
MgpMYMedulla2.97
7.57
MgpOLFOlfactory bulb3.21
3.18
MgpPPons3.6
8.09
MgpPALPallidum1.07
1.92
MgpRHPRetrohippocampal region1.88
2.68
MgpsAMYStriatum-like amygdalar nuclei6.25
13.99
MgpSTRStriatum1.98
3.63
MgpSTRdStriatum dorsal region1.33
2.15
MgpSTRvStriatum ventral region0.66
0.8
MgpTHThalamus1.85
4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MGP_HUMAN_39 11 39 49 NANTFISPQQR PRIDE
PAp00136104 11 39 49 NANTFISPQQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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