AutismKB 2.0

Annotation Detail for MKI67


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Basic Information Top
Gene Symbol:MKI67 ( KIA )
Gene Full Name: antigen identified by monoclonal antibody Ki-67
Band: 10q26.2
Quick LinksEntrez ID:4288; OMIM: 176741; Uniprot ID:KI67_HUMAN; ENSEMBL ID: ENSG00000148773; HGNC ID: 7107
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst5 / 6231980
fetus80 / 564012141
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult191 / 193912198
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma2 / 17475114
breast (mammary gland) tumor15 / 94178159
cervical tumor6 / 34366174
chondrosarcoma11 / 82823132
colorectal tumor34 / 114246297
esophageal tumor4 / 17290231
gastrointestinal tumor14 / 119369117
germ cell tumor24 / 26384590
glioma10 / 10688393
head and neck tumor11 / 13630280
kidney tumor5 / 6895972
leukemia28 / 95842292
liver tumor9 / 9635993
lung tumor6 / 10312758
lymphoma11 / 71755153
non-neoplasia1 / 9725010
normal195 / 336030758
ovarian tumor8 / 76682104
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor23 / 90257254
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites9 / 40015224
bladder5 / 29757168
blood26 / 123478210
bone13 / 71655181
bone marrow4 / 4880181
brain14 / 110098912
cervix10 / 48171207
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus4 / 20209197
eye6 / 21105428
heart9 / 89626100
intestine44 / 234472187
kidney16 / 21177775
larynx1 / 2414541
liver35 / 207743168
lung24 / 33697471
lymph10 / 44270225
lymph node42 / 91610458
mammary gland18 / 153271117
mouth3 / 6705244
muscle7 / 10771564
nerve0 / 157680 
ovary9 / 10205188
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta7 / 28082524
prostate6 / 18934531
salivary gland0 / 201550 
skin6 / 21057428
spleen1 / 5395218
stomach3 / 9661931
testis12 / 33044236
thymus16 / 81131197
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus32 / 232878137
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212022_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts806.5
Adipocyte17.25
AdrenalCortex23.5
Adrenalgland15.05
Amygdala18.45
Appendix20.5
AtrioventricularNode16.4
BDCA4+_DentriticCells22.15
Bonemarrow20.65
BronchialEpithelialCells18.75
CD105+_Endothelial104.4
CD14+_Monocytes14.75
CD19+_BCells(neg._sel.)17
CD33+_Myeloid27
CD34+51.15
CD4+_Tcells19.75
CD56+_NKCells18.3
CD71+_EarlyErythroid429.55
CD8+_Tcells17.75
CardiacMyocytes78.85
Caudatenucleus14.4
Cerebellum15.2
CerebellumPeduncles22.35
CiliaryGanglion13.75
CingulateCortex20.55
Colorectaladenocarcinoma147.85
DorsalRootGanglion18.7
FetalThyroid19.95
Fetalbrain18.7
Fetalliver49.45
Fetallung15.65
GlobusPallidus13.6
Heart40.95
Hypothalamus17.1
Kidney15.35
Leukemia_chronicMyelogenousK-56226.75
Leukemia_promyelocytic-HL-60142.65
Leukemialymphoblastic(MOLT-4)332.6
Liver29.65
Lung20.65
Lymphnode15.8
Lymphoma_burkitts(Daudi)216.8
Lymphoma_burkitts(Raji)41
MedullaOblongata14.65
OccipitalLobe13.65
OlfactoryBulb14.5
Ovary14.2
Pancreas15.65
PancreaticIslet20.95
ParietalLobe19.6
Pituitary21.85
Placenta19.1
Pons17.95
PrefrontalCortex19.45
Prostate21.55
Salivarygland20.75
SkeletalMuscle37.8
Skin23.5
SmoothMuscle18.25
Spinalcord20.05
SubthalamicNucleus17.25
SuperiorCervicalGanglion35.3
TemporalLobe17.1
Testis16.1
TestisGermCell18.9
TestisIntersitial16
TestisLeydigCell18.6
TestisSeminiferousTubule15.55
Thalamus18.8
Thymus53.3
Thyroid22.95
Tongue20.15
Tonsil29.1
Trachea15.05
TrigeminalGanglion22.75
Uterus14.75
UterusCorpus23.5
WholeBlood17.55
Wholebrain13.4
colon29.15
pineal_day20.92
pineal_night19.18
retina21.625
small_intestine18.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P346855
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.02 ± 1.02
Basal Forebrain1.58 ± 0.19
Basal Part of Pons1.42 ± 0.5
Cerebellar Cortex1.37 ± 0.7
Cerebellar Nuclei1.85 ± 0.75
Claustrum2.51 ± 0.84
Epithalamus1.28 ± 0.7
Frontal Lobe1.41 ± 0.62
Globus Pallidus2.2 ± 0.34
Hypothalamus1.7 ± 0.71
Insula1.48 ± 0.57
Limbic Lobe1.57 ± 0.63
Mesencephalon1.69 ± 0.65
Myelencephalon1.59 ± 0.72
Occipital Lobe1.64 ± 0.66
Parietal Lobe1.56 ± 0.78
Pontine Tegmentum1.66 ± 0.76
Striatum1.79 ± 0.54
Subthalamus1.68 ± 0.56
Temporal Lobe1.48 ± 0.63
Thalamus1.54 ± 0.6
White Matter2.07 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mki67CBCerebellum4.78
4.6
Mki67CTXCerebral cortex2.25
1.73
Mki67HIPHippocampal region2.8
3.51
Mki67HPFHippocampal formation2.57
2.93
Mki67HYHypothalamus4.25
2.49
Mki67LSXLateral septal complex4.31
5.12
Mki67MBMidbrain2.96
3.49
Mki67MYMedulla2.98
2.89
Mki67OLFOlfactory bulb3.54
3.03
Mki67PPons3.13
3.36
Mki67PALPallidum1.3
1.11
Mki67RHPRetrohippocampal region2.11
1.92
Mki67sAMYStriatum-like amygdalar nuclei2.79
1.92
Mki67STRStriatum2.82
3.14
Mki67STRdStriatum dorsal region2.21
2.74
Mki67STRvStriatum ventral region2.29
1.67
Mki67THThalamus1.53
1.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KI67_HUMAN_108 6 108 113 STEFPR PRIDE
KI67_HUMAN_1094 13 1094 1106 EEAQSLEDLAGFK PRIDE
KI67_HUMAN_1127 18 1127 1144 IACKSPPPESVDTPTSTK PRIDE
KI67_HUMAN_1189 9 1189 1197 AFMGTPVQK PRIDE
KI67_HUMAN_1249 18 1249 1266 IPCDSPQSDPVDTPTSTK PRIDE
KI67_HUMAN_1320 11 1320 1330 LDLTENLTGSK PRIDE
KI67_HUMAN_1332 19 1332 1350 RPQTPKEEAQALEDLTGFK PRIDE
KI67_HUMAN_1371 18 1371 1388 MPCESSPPESADTPTSTR PRIDE
KI67_HUMAN_1550 12 1550 1561 NIAYFMGTPVQK PRIDE
KI67_HUMAN_1739 18 1739 1756 ASQPDLVDTPTSSKPQPK PRIDE
KI67_HUMAN_1794 12 1794 1805 DINTFLGTPVQK PRIDE
KI67_HUMAN_1806 12 1806 1817 LDQPGNLPGSNR PRIDE
KI67_HUMAN_1857 18 1857 1874 ILCKSPQSDPADTPTNTK PRIDE
KI67_HUMAN_1861 14 1861 1874 SPQSDPADTPTNTK PRIDE
KI67_HUMAN_1916 12 1916 1927 DINTFVGTPVEK PRIDE
KI67_HUMAN_1999 7 1999 2005 LKISLGK PRIDE
KI67_HUMAN_2081 17 2081 2097 ELFQTPDHTEESTTDDK PRIDE
KI67_HUMAN_2101 18 2101 2118 IACKSPPPESMDTPTSTR PRIDE
KI67_HUMAN_2153 9 2153 2161 EDKGINVFR PRIDE
KI67_HUMAN_2219 22 2219 2240 IACRSPQPDPVGTPTIFKPQSK PRIDE
KI67_HUMAN_2223 18 2223 2240 SPQPDPVGTPTIFKPQSK PRIDE
KI67_HUMAN_2400 12 2400 2411 NINTFVETPVQK PRIDE
KI67_HUMAN_2704 18 2704 2721 IPCESPPLEVVDTTASTK PRIDE
KI67_HUMAN_2823 17 2823 2839 IPCKSSPELEDTATSSK PRIDE
KI67_HUMAN_2827 13 2827 2839 SSPELEDTATSSK PRIDE
KI67_HUMAN_296 22 296 317 SGGSGHAVAEPASPEQELDQNK PRIDE
KI67_HUMAN_372 8 372 379 RESVNLGK PRIDE
KI67_HUMAN_538 11 538 548 SLVMHTPPVLK PRIDE
KI67_HUMAN_573 14 573 586 AQSLVISPPAPSPR PRIDE
KI67_HUMAN_648 12 648 659 SGASEANLIVAK PRIDE
PAp00000666 28 1101 1128 AQPLEDLAGLKELFQTPVCTDKPTTHEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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