AutismKB 2.0

Annotation Detail for MAP3K10


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Basic Information Top
Gene Symbol:MAP3K10 ( MEKK10,MLK2,MST )
Gene Full Name: mitogen-activated protein kinase kinase kinase 10
Band: 19q13.2
Quick LinksEntrez ID:4294; OMIM: 600137; Uniprot ID:M3K10_HUMAN; ENSEMBL ID: ENSG00000130758; HGNC ID: 6849
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal36 / 336030710
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain10 / 11009899
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung5 / 33697414
lymph1 / 4427022
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate3 / 18934515
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach7 / 9661972
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206362_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.15
Adipocyte16.15
AdrenalCortex19.25
Adrenalgland15.7
Amygdala22.15
Appendix15.95
AtrioventricularNode11.9
BDCA4+_DentriticCells10.5
Bonemarrow16.3
BronchialEpithelialCells15.8
CD105+_Endothelial12.3
CD14+_Monocytes12.15
CD19+_BCells(neg._sel.)12.8
CD33+_Myeloid13.65
CD34+13.2
CD4+_Tcells15.3
CD56+_NKCells13.25
CD71+_EarlyErythroid12.9
CD8+_Tcells10.2
CardiacMyocytes20.05
Caudatenucleus24.1
Cerebellum28.3
CerebellumPeduncles20.15
CiliaryGanglion11
CingulateCortex23.75
Colorectaladenocarcinoma15.95
DorsalRootGanglion11.95
FetalThyroid15.7
Fetalbrain18.25
Fetalliver13.9
Fetallung13.1
GlobusPallidus12.05
Heart21.15
Hypothalamus18
Kidney20.25
Leukemia_chronicMyelogenousK-56217.3
Leukemia_promyelocytic-HL-6014.4
Leukemialymphoblastic(MOLT-4)13.65
Liver22.05
Lung16.9
Lymphnode15.4
Lymphoma_burkitts(Daudi)21.2
Lymphoma_burkitts(Raji)22.1
MedullaOblongata19.55
OccipitalLobe15.35
OlfactoryBulb12.8
Ovary10.55
Pancreas13.1
PancreaticIslet22.6
ParietalLobe25.9
Pituitary30.05
Placenta17
Pons18.2
PrefrontalCortex20.7
Prostate19.25
Salivarygland12.8
SkeletalMuscle19.8
Skin12.4
SmoothMuscle18.4
Spinalcord18
SubthalamicNucleus14.9
SuperiorCervicalGanglion19.15
TemporalLobe18.75
Testis15.6
TestisGermCell11.75
TestisIntersitial13.6
TestisLeydigCell18.3
TestisSeminiferousTubule14
Thalamus16.75
Thymus12.85
Thyroid19.9
Tongue16.65
Tonsil15.65
Trachea13.7
TrigeminalGanglion16.05
Uterus11.55
UterusCorpus14.05
WholeBlood17.3
Wholebrain18.1
colon10.8
pineal_day19.14
pineal_night17
retina17.7
small_intestine12.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9747_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.75 ± 0.46
Basal Forebrain5.4 ± 0.26
Basal Part of Pons5.91 ± 0.36
Cerebellar Cortex5.36 ± 0.36
Cerebellar Nuclei5.42 ± 0.3
Claustrum6.06 ± 0.49
Epithalamus4.92 ± 0.24
Frontal Lobe5.51 ± 0.43
Globus Pallidus5.49 ± 0.22
Hypothalamus5.29 ± 0.43
Insula5.57 ± 0.34
Limbic Lobe5.74 ± 0.44
Mesencephalon5.55 ± 0.42
Myelencephalon5.61 ± 0.49
Occipital Lobe5.76 ± 0.41
Parietal Lobe5.64 ± 0.45
Pontine Tegmentum5.46 ± 0.36
Striatum5.85 ± 0.39
Subthalamus5.39 ± 0.3
Temporal Lobe5.59 ± 0.42
Thalamus5.56 ± 0.4
White Matter5.08 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k10CBCerebellum1.4
2.46
Map3k10CTXCerebral cortex0.69
0.72
Map3k10HIPHippocampal region0.81
1.14
Map3k10HPFHippocampal formation0.6
0.83
Map3k10HYHypothalamus0.17
0.14
Map3k10LSXLateral septal complex0.14
0.21
Map3k10MBMidbrain0.61
0.98
Map3k10MYMedulla0.45
1.03
Map3k10OLFOlfactory bulb0.83
1.18
Map3k10PPons0.22
0.3
Map3k10PALPallidum0.35
0.3
Map3k10RHPRetrohippocampal region0.19
0.28
Map3k10sAMYStriatum-like amygdalar nuclei0.41
0.54
Map3k10STRStriatum0.36
0.38
Map3k10STRdStriatum dorsal region0.37
0.41
Map3k10STRvStriatum ventral region0.39
0.26
Map3k10THThalamus0.65
0.62
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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