AutismKB 2.0

Annotation Detail for MLLT4


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Basic Information Top
Gene Symbol:MLLT4 ( AF6,FLJ34371,RP3-431P23.3 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Band: 6q27
Quick LinksEntrez ID:4301; OMIM: 159559; Uniprot ID:Q59FP0_HUMAN; ENSEMBL ID: ENSG00000130396,ENSG00000249273; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus41 / 56401272
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult130 / 193912167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor15 / 114246131
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor17 / 26384564
glioma2 / 10688318
head and neck tumor14 / 136302102
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor11 / 96359114
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal195 / 336030758
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain53 / 110098948
cervix0 / 481710 
connective tissue7 / 14925546
ear4 / 16212246
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye16 / 21105475
heart3 / 8962633
intestine18 / 23447276
kidney10 / 21177747
larynx6 / 24145248
liver16 / 20774377
lung26 / 33697477
lymph0 / 442700 
lymph node4 / 9161043
mammary gland16 / 153271104
mouth7 / 67052104
muscle5 / 10771546
nerve0 / 157680 
ovary4 / 10205139
pancreas6 / 21481227
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta18 / 28082564
prostate8 / 18934542
salivary gland0 / 201550 
skin9 / 21057442
spleen1 / 5395218
stomach6 / 9661962
testis29 / 33044287
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea6 / 52413114
umbilical cord0 / 136800 
uterus9 / 23287838
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214939_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.2
Adipocyte4.9
AdrenalCortex5.4
Adrenalgland4.2
Amygdala5.2
Appendix5.05
AtrioventricularNode4.05
BDCA4+_DentriticCells5.1
Bonemarrow4.85
BronchialEpithelialCells4.9
CD105+_Endothelial5
CD14+_Monocytes5.25
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid6.25
CD34+6.35
CD4+_Tcells5.3
CD56+_NKCells5.75
CD71+_EarlyErythroid4.65
CD8+_Tcells4.65
CardiacMyocytes6.25
Caudatenucleus4.45
Cerebellum4
CerebellumPeduncles5.75
CiliaryGanglion3.7
CingulateCortex5.15
Colorectaladenocarcinoma4.95
DorsalRootGanglion3.95
FetalThyroid4.75
Fetalbrain4.9
Fetalliver4.3
Fetallung4.2
GlobusPallidus3.75
Heart6.75
Hypothalamus5.4
Kidney4.05
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)4
Liver6.6
Lung5.4
Lymphnode4.2
Lymphoma_burkitts(Daudi)6.3
Lymphoma_burkitts(Raji)7
MedullaOblongata4.55
OccipitalLobe4.45
OlfactoryBulb3.9
Ovary3.25
Pancreas4
PancreaticIslet6.7
ParietalLobe5.45
Pituitary5.8
Placenta5.1
Pons4.75
PrefrontalCortex6.35
Prostate5.8
Salivarygland4.65
SkeletalMuscle6.05
Skin4.05
SmoothMuscle5.75
Spinalcord5.3
SubthalamicNucleus4.5
SuperiorCervicalGanglion5.95
TemporalLobe4.5
Testis4.2
TestisGermCell4.3
TestisIntersitial4.1
TestisLeydigCell4.9
TestisSeminiferousTubule4.25
Thalamus5.05
Thymus3.8
Thyroid6.1
Tongue4.95
Tonsil4.85
Trachea4.15
TrigeminalGanglion5.1
Uterus4
UterusCorpus4.6
WholeBlood5.35
Wholebrain4.25
colon4.95
pineal_day6.06
pineal_night6.04
retina5.95
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12514_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.88 ± 0.42
Basal Forebrain6.67 ± 0.29
Basal Part of Pons6.34 ± 0.25
Cerebellar Cortex6.53 ± 0.3
Cerebellar Nuclei6.68 ± 0.3
Claustrum7.11 ± 0.49
Epithalamus6.08 ± 0.18
Frontal Lobe6.48 ± 0.36
Globus Pallidus7.27 ± 0.17
Hypothalamus6.46 ± 0.23
Insula6.51 ± 0.35
Limbic Lobe6.79 ± 0.4
Mesencephalon6.75 ± 0.26
Myelencephalon6.57 ± 0.38
Occipital Lobe6.82 ± 0.4
Parietal Lobe6.63 ± 0.37
Pontine Tegmentum6.6 ± 0.34
Striatum6.45 ± 0.38
Subthalamus6.6 ± 0.31
Temporal Lobe6.49 ± 0.33
Thalamus6.53 ± 0.26
White Matter7.36 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mllt4CBCerebellum11.29
11.24
Mllt4CTXCerebral cortex23.22
16.71
Mllt4HIPHippocampal region24.06
25.23
Mllt4HPFHippocampal formation23.32
22
Mllt4HYHypothalamus4.71
3.55
Mllt4LSXLateral septal complex2.22
1.93
Mllt4MBMidbrain7.53
6.42
Mllt4MYMedulla10.03
9.96
Mllt4OLFOlfactory bulb23.92
20.21
Mllt4PPons9.95
9.23
Mllt4PALPallidum6.52
5.82
Mllt4RHPRetrohippocampal region21.44
16.21
Mllt4sAMYStriatum-like amygdalar nuclei7.16
5
Mllt4STRStriatum4.32
3.66
Mllt4STRdStriatum dorsal region3.77
3.79
Mllt4STRvStriatum ventral region5.36
3.65
Mllt4THThalamus2.13
1.95
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005824 16 947 962 NIPNGLQEFLDPLCQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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