AutismKB 2.0

Annotation Detail for NR3C2


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Basic Information Top
Gene Symbol:NR3C2 ( FLJ41052,MCR,MGC133092,MLR,MR,NR3C2VIT )
Gene Full Name: nuclear receptor subfamily 3, group C, member 2
Band: 4q31
Quick LinksEntrez ID:4306; OMIM: 600983; Uniprot ID:MCR_HUMAN; ENSEMBL ID: ENSG00000151623; HGNC ID: 7979
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal76 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain9 / 11009898
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye13 / 21105461
heart0 / 896260 
intestine9 / 23447238
kidney9 / 21177742
larynx0 / 241450 
liver3 / 20774314
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate2 / 18934510
salivary gland1 / 2015549
skin0 / 2105740 
spleen1 / 5395218
stomach12 / 96619124
testis11 / 33044233
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205259_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.15
Adipocyte6.45
AdrenalCortex7.5
Adrenalgland5.75
Amygdala28.05
Appendix7.35
AtrioventricularNode5.85
BDCA4+_DentriticCells6.3
Bonemarrow6.9
BronchialEpithelialCells6.3
CD105+_Endothelial6.25
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)8.95
CD33+_Myeloid7.55
CD34+7.3
CD4+_Tcells10.15
CD56+_NKCells6.9
CD71+_EarlyErythroid6.2
CD8+_Tcells16.35
CardiacMyocytes10.2
Caudatenucleus6.8
Cerebellum7.5
CerebellumPeduncles7.9
CiliaryGanglion5.2
CingulateCortex7.4
Colorectaladenocarcinoma6.7
DorsalRootGanglion5.6
FetalThyroid8.7
Fetalbrain6.4
Fetalliver5.75
Fetallung8.2
GlobusPallidus5.25
Heart9.45
Hypothalamus8.7
Kidney5.85
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.8
Leukemialymphoblastic(MOLT-4)4.9
Liver9.5
Lung7.65
Lymphnode5.95
Lymphoma_burkitts(Daudi)8.7
Lymphoma_burkitts(Raji)10.15
MedullaOblongata7.35
OccipitalLobe10.4
OlfactoryBulb7.35
Ovary5.05
Pancreas5.55
PancreaticIslet8.85
ParietalLobe7.55
Pituitary15.8
Placenta6.4
Pons6.75
PrefrontalCortex85.6
Prostate7.9
Salivarygland6.55
SkeletalMuscle8.45
Skin6.1
SmoothMuscle7.35
Spinalcord7.35
SubthalamicNucleus6.55
SuperiorCervicalGanglion8.05
TemporalLobe6.25
Testis5.6
TestisGermCell5.45
TestisIntersitial6.45
TestisLeydigCell6.75
TestisSeminiferousTubule5.6
Thalamus6.9
Thymus5.15
Thyroid93.65
Tongue7.15
Tonsil6.55
Trachea5.6
TrigeminalGanglion6.9
Uterus13.05
UterusCorpus6.6
WholeBlood7
Wholebrain17.95
colon91.05
pineal_day10.62
pineal_night13.08
retina8.875
small_intestine17.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14304_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.67 ± 0.81
Basal Forebrain4.29 ± 0.27
Basal Part of Pons4.49 ± 0.49
Cerebellar Cortex4.34 ± 0.59
Cerebellar Nuclei3.91 ± 0.48
Claustrum3.78 ± 0.62
Epithalamus4.35 ± 0.25
Frontal Lobe4.44 ± 0.65
Globus Pallidus4.79 ± 0.42
Hypothalamus4.05 ± 0.35
Insula4.28 ± 0.45
Limbic Lobe4.93 ± 0.65
Mesencephalon4.4 ± 0.55
Myelencephalon4.45 ± 0.53
Occipital Lobe5.08 ± 0.51
Parietal Lobe4.86 ± 0.56
Pontine Tegmentum4.51 ± 0.7
Striatum4.43 ± 0.52
Subthalamus4.65 ± 0.69
Temporal Lobe4.48 ± 0.6
Thalamus4.4 ± 0.65
White Matter3.71 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nr3c2CBCerebellum0.47
0.85
Nr3c2CTXCerebral cortex0.83
0.67
Nr3c2HIPHippocampal region46.14
28.15
Nr3c2HPFHippocampal formation33.73
19.25
Nr3c2HYHypothalamus0.21
0.19
Nr3c2LSXLateral septal complex3.86
1.68
Nr3c2MBMidbrain1.13
0.69
Nr3c2MYMedulla1.24
0.96
Nr3c2OLFOlfactory bulb1.67
1.46
Nr3c2PPons0.67
0.58
Nr3c2PALPallidum0.22
0.27
Nr3c2RHPRetrohippocampal region7.63
4.52
Nr3c2sAMYStriatum-like amygdalar nuclei0.47
0.44
Nr3c2STRStriatum0.52
0.33
Nr3c2STRdStriatum dorsal region0.13
0.15
Nr3c2STRvStriatum ventral region0.35
0.18
Nr3c2THThalamus4.98
3.59
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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