Annotation Detail for MME
Basic Information Top
| Gene Symbol: | MME ( CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP ) |
|---|---|
| Gene Full Name: | membrane metallo-endopeptidase |
| Band: | 3q25.2 |
| Quick Links | Entrez ID:4311; OMIM: 120520; Uniprot ID:NEP_HUMAN; ENSEMBL ID: ENSG00000196549; HGNC ID: 7154 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.307734
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 13 / 70761 | 183 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 44 / 564012 | 78 | |
| neonate | 4 / 31097 | 128 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 |  |
| adult | 128 / 1939121 | 66 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 8 / 12794 | 625 |  |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 25 / 82823 | 301 | |
| colorectal tumor | 6 / 114246 | 52 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 5 / 263845 | 18 | |
| glioma | 1 / 106883 | 9 |  |
| head and neck tumor | 2 / 136302 | 14 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 13 / 95842 | 135 | |
| liver tumor | 9 / 96359 | 93 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 4 / 71755 | 55 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 238 / 3360307 | 70 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 1 / 125680 | 7 | |
| prostate cancer | 20 / 102680 | 194 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 11 / 124949 | 88 | |
| soft tissue/muscle tissue tumor | 10 / 125191 | 79 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 8 / 33197 | 240 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 1 / 123478 | 8 | |
| bone | 21 / 71655 | 293 | |
| bone marrow | 4 / 48801 | 81 | |
| brain | 6 / 1100989 | 5 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 17 / 149255 | 113 | |
| ear | 2 / 16212 | 123 | |
| embryonic tissue | 13 / 215722 | 60 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 9 / 89626 | 100 | |
| intestine | 10 / 234472 | 42 | |
| kidney | 70 / 211777 | 330 | |
| larynx | 2 / 24145 | 82 | |
| liver | 9 / 207743 | 43 | |
| lung | 7 / 336974 | 20 | |
| lymph | 4 / 44270 | 90 | |
| lymph node | 33 / 91610 | 360 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 6 / 107715 | 55 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 2 / 102051 | 19 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 40 / 280825 | 142 | |
| prostate | 31 / 189345 | 163 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 20 / 210574 | 94 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 1 / 96619 | 10 | |
| testis | 6 / 330442 | 18 | |
| thymus | 5 / 81131 | 61 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 2 / 16999 | 117 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 10 / 232878 | 42 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203434_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 4.95 | |
| Adipocyte | 707.1 | |
| AdrenalCortex | 4.35 | |
| Adrenalgland | 3.45 | |
| Amygdala | 4.15 | |
| Appendix | 4.1 | |
| AtrioventricularNode | 3.95 | |
| BDCA4+_DentriticCells | 5.7 | |
| Bonemarrow | 4.05 | |
| BronchialEpithelialCells | 3.95 | |
| CD105+_Endothelial | 9.1 | |
| CD14+_Monocytes | 4.3 | |
| CD19+_BCells(neg._sel.) | 4.25 | |
| CD33+_Myeloid | 5.45 | |
| CD34+ | 20 | |
| CD4+_Tcells | 4.4 | |
| CD56+_NKCells | 4.8 | |
| CD71+_EarlyErythroid | 3.8 | |
| CD8+_Tcells | 3.75 | |
| CardiacMyocytes | 5.55 | |
| Caudatenucleus | 3.65 | |
| Cerebellum | 3.25 | |
| CerebellumPeduncles | 4.65 | |
| CiliaryGanglion | 2.9 | |
| CingulateCortex | 4.2 | |
| Colorectaladenocarcinoma | 4.05 | |
| DorsalRootGanglion | 4.25 | |
| FetalThyroid | 3.95 | |
| Fetalbrain | 3.9 | |
| Fetalliver | 3.55 | |
| Fetallung | 3.3 | |
| GlobusPallidus | 3 | |
| Heart | 5.75 | |
| Hypothalamus | 4.45 | |
| Kidney | 7.7 | |
| Leukemia_chronicMyelogenousK-562 | 3.65 | |
| Leukemia_promyelocytic-HL-60 | 6.9 | |
| Leukemialymphoblastic(MOLT-4) | 3.25 | |
| Liver | 5.55 | |
| Lung | 4.4 | |
| Lymphnode | 3.45 | |
| Lymphoma_burkitts(Daudi) | 130.6 | |
| Lymphoma_burkitts(Raji) | 6.05 | |
| MedullaOblongata | 3.7 | |
| OccipitalLobe | 3.6 | |
| OlfactoryBulb | 189.8 | |
| Ovary | 2.7 | |
| Pancreas | 3.25 | |
| PancreaticIslet | 4.3 | |
| ParietalLobe | 4.3 | |
| Pituitary | 4.75 | |
| Placenta | 5.1 | |
| Pons | 3.85 | |
| PrefrontalCortex | 4.95 | |
| Prostate | 82.5 | |
| Salivarygland | 3.25 | |
| SkeletalMuscle | 4.75 | |
| Skin | 3.2 | |
| SmoothMuscle | 44.2 | |
| Spinalcord | 4.3 | |
| SubthalamicNucleus | 3.7 | |
| SuperiorCervicalGanglion | 5.15 | |
| TemporalLobe | 3.7 | |
| Testis | 3.45 | |
| TestisGermCell | 3.3 | |
| TestisIntersitial | 3.35 | |
| TestisLeydigCell | 4 | |
| TestisSeminiferousTubule | 3.45 | |
| Thalamus | 4.1 | |
| Thymus | 3.2 | |
| Thyroid | 5 | |
| Tongue | 4.1 | |
| Tonsil | 3.95 | |
| Trachea | 3.35 | |
| TrigeminalGanglion | 4.35 | |
| Uterus | 3.3 | |
| UterusCorpus | 6 | |
| WholeBlood | 204.9 | |
| Wholebrain | 3.3 | |
| colon | 4 | |
| pineal_day | 4.96 | |
| pineal_night | 4.88 | |
| retina | 4.85 | |
| small_intestine | 73.4 | |
- Probe name: A_24_P260101
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.7 ± 1.24 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.69 ± 0.77 | |
| Basal Part of Pons | 4.83 ± 0.59 | |
| Cerebellar Cortex | 1.73 ± 0.44 | |
| Cerebellar Nuclei | 2.5 ± 0.84 | |
| Claustrum | 2.95 ± 0.72 | |
| Epithalamus | 2.34 ± 1.5 | |
| Frontal Lobe | 2.13 ± 0.72 | |
| Globus Pallidus | 2.58 ± 0.68 | |
| Hypothalamus | 2.56 ± 1.35 | |
| Insula | 2.04 ± 0.6 | |
| Limbic Lobe | 2.11 ± 0.73 | |
| Mesencephalon | 2.43 ± 0.99 | |
| Myelencephalon | 2.55 ± 1.06 | |
| Occipital Lobe | 2.64 ± 1.13 | |
| Parietal Lobe | 2.47 ± 1.12 | |
| Pontine Tegmentum | 2.06 ± 0.74 | |
| Striatum | 5.86 ± 1.18 | |
| Subthalamus | 2.54 ± 0.82 | |
| Temporal Lobe | 2.22 ± 0.7 | |
| Thalamus | 2.94 ± 0.86 | |
| White Matter | 2.44 ± 0.31 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Mme | CB | Cerebellum | 7.16 | |
| 7.9 | | |||
| Mme | CTX | Cerebral cortex | 4.64 | |
| 3.71 | | |||
| Mme | HIP | Hippocampal region | 5.35 | |
| 6.31 | | |||
| Mme | HPF | Hippocampal formation | 6.31 | |
| 6.44 | | |||
| Mme | HY | Hypothalamus | 6.51 | |
| 5.72 | | |||
| Mme | LSX | Lateral septal complex | 0.37 | |
| 0.27 | | |||
| Mme | MB | Midbrain | 4.32 | |
| 4 | | |||
| Mme | MY | Medulla | 9.51 | |
| 9.95 | | |||
| Mme | OLF | Olfactory bulb | 3.97 | |
| 3.93 | | |||
| Mme | P | Pons | 6.36 | |
| 6.43 | | |||
| Mme | PAL | Pallidum | 10.66 | |
| 11.16 | | |||
| Mme | RHP | Retrohippocampal region | 8.28 | |
| 6.96 | | |||
| Mme | sAMY | Striatum-like amygdalar nuclei | 1.53 | |
| 1.47 | | |||
| Mme | STR | Striatum | 23.78 | |
| 20.8 | | |||
| Mme | STRd | Striatum dorsal region | 34.84 | |
| 30.9 | | |||
| Mme | STRv | Striatum ventral region | 9.54 | |
| 8.2 | | |||
| Mme | TH | Thalamus | 4.72 | |
| 4.65 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| NEP_HUMAN_261 | 14 | 261 | 274 | LPIDENQLALEMNK | PRIDE |
| NEP_HUMAN_374 | 11 | 374 | 384 | FIMDLVSSLSR | PRIDE |
| NEP_HUMAN_437 | 11 | 437 | 447 | HVVEDLIAQIR | PRIDE |
| PAp00000580 | 13 | 397 | 409 | ALYGTTSETATWR | Peptide Atlas |