AutismKB 2.0

Annotation Detail for MMP9


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Basic Information Top
Gene Symbol:MMP9 ( CLG4B,GELB,MANDP2,MMP-9 )
Gene Full Name: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Band: 20q13.12
Quick LinksEntrez ID:4318; OMIM: 120361; Uniprot ID:MMP9_HUMAN; ENSEMBL ID: ENSG00000100985; HGNC ID: 7176
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst0 / 623190 
fetus1 / 5640121
neonate321 / 3109710322
infant0 / 236200 
juvenile0 / 555560 
adult121 / 193912162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor3 / 17290173
gastrointestinal tumor0 / 1193690 
germ cell tumor14 / 26384553
glioma5 / 10688346
head and neck tumor32 / 136302234
kidney tumor1 / 6895914
leukemia103 / 958421074
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia8 / 9725082
normal759 / 3360307225
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood407 / 1234783296
bone9 / 71655125
bone marrow1 / 4880120
brain10 / 11009899
cervix1 / 4817120
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus4 / 20209197
eye3 / 21105414
heart0 / 896260 
intestine12 / 23447251
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung10 / 33697429
lymph0 / 442700 
lymph node5 / 9161054
mammary gland4 / 15327126
mouth12 / 67052178
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx20 / 41328483
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen19 / 53952352
stomach1 / 9661910
testis1 / 3304423
thymus16 / 81131197
thyroid0 / 474730 
tonsil4 / 16999235
trachea3 / 5241357
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203936_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10
Adipocyte4.45
AdrenalCortex4.7
Adrenalgland3.9
Amygdala4.65
Appendix4.45
AtrioventricularNode3.35
BDCA4+_DentriticCells4.15
Bonemarrow382.4
BronchialEpithelialCells4.4
CD105+_Endothelial5.9
CD14+_Monocytes4.65
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid5.85
CD34+5.55
CD4+_Tcells4.65
CD56+_NKCells4.9
CD71+_EarlyErythroid4
CD8+_Tcells3.8
CardiacMyocytes5.5
Caudatenucleus4
Cerebellum4.4
CerebellumPeduncles5.15
CiliaryGanglion3.15
CingulateCortex4.55
Colorectaladenocarcinoma6
DorsalRootGanglion3.4
FetalThyroid4.3
Fetalbrain5.65
Fetalliver3.8
Fetallung6
GlobusPallidus3.35
Heart14.75
Hypothalamus4.8
Kidney3.65
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-604.45
Leukemialymphoblastic(MOLT-4)4.85
Liver6.05
Lung5.35
Lymphnode204.45
Lymphoma_burkitts(Daudi)5.7
Lymphoma_burkitts(Raji)55.55
MedullaOblongata4
OccipitalLobe4.55
OlfactoryBulb3.45
Ovary3.05
Pancreas3.6
PancreaticIslet5.3
ParietalLobe4.9
Pituitary5.25
Placenta5
Pons4.9
PrefrontalCortex5.35
Prostate5.15
Salivarygland10.35
SkeletalMuscle5.5
Skin3.45
SmoothMuscle5.05
Spinalcord4.8
SubthalamicNucleus4.1
SuperiorCervicalGanglion5.1
TemporalLobe4.05
Testis3.8
TestisGermCell3.7
TestisIntersitial3.7
TestisLeydigCell4.2
TestisSeminiferousTubule4.1
Thalamus4.55
Thymus52.3
Thyroid11.5
Tongue4.4
Tonsil141.4
Trachea3.9
TrigeminalGanglion4.45
Uterus3.55
UterusCorpus5.6
WholeBlood107.45
Wholebrain3.95
colon4.45
pineal_day5.16
pineal_night5.38
retina5.35
small_intestine4.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16787_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.32 ± 1.01
Basal Forebrain1.94 ± 0.39
Basal Part of Pons1.58 ± 0.33
Cerebellar Cortex2.11 ± 0.8
Cerebellar Nuclei2.19 ± 0.71
Claustrum2.83 ± 0.95
Epithalamus1.6 ± 0.79
Frontal Lobe1.75 ± 0.58
Globus Pallidus2.3 ± 0.75
Hypothalamus1.95 ± 0.65
Insula1.96 ± 0.55
Limbic Lobe1.94 ± 0.64
Mesencephalon2.07 ± 0.69
Myelencephalon1.95 ± 0.64
Occipital Lobe2.09 ± 0.77
Parietal Lobe1.97 ± 0.7
Pontine Tegmentum1.97 ± 0.68
Striatum1.85 ± 0.51
Subthalamus2.09 ± 0.68
Temporal Lobe1.86 ± 0.71
Thalamus1.86 ± 0.62
White Matter2.43 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mmp9RHPRetrohippocampal region13.15
10.04
Mmp9sAMYStriatum-like amygdalar nuclei10.94
10.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MMP9_HUMAN_567 11 567 577 LDSVFEEPLSK PRIDE
PAp00005463 13 371 383 LWCATTSNFDSDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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