AutismKB 2.0

Annotation Detail for MMP11


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Basic Information Top
Gene Symbol:MMP11 ( SL-3,ST3,STMY3 )
Gene Full Name: matrix metallopeptidase 11 (stromelysin 3)
Band: 22q11.23
Quick LinksEntrez ID:4320; OMIM: 185261; Uniprot ID:MMP11_HUMAN; ENSEMBL ID: ENSG00000099953; HGNC ID: 7157
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus37 / 56401265
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult297 / 1939121153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor0 / 1193690 
germ cell tumor23 / 26384587
glioma0 / 1068830 
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal310 / 336030792
ovarian tumor21 / 76682273
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain9 / 11009898
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus2 / 2020998
eye1 / 2110544
heart3 / 8962633
intestine23 / 23447298
kidney4 / 21177718
larynx3 / 24145124
liver4 / 20774319
lung16 / 33697447
lymph0 / 442700 
lymph node4 / 9161043
mammary gland10 / 15327165
mouth5 / 6705274
muscle1 / 1077159
nerve0 / 157680 
ovary24 / 102051235
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta206 / 280825733
prostate6 / 18934531
salivary gland1 / 2015549
skin5 / 21057423
spleen2 / 5395237
stomach0 / 966190 
testis24 / 33044272
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus30 / 232878128
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203876_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.4
Adipocyte4.4
AdrenalCortex4.8
Adrenalgland3.8
Amygdala4.65
Appendix4.6
AtrioventricularNode3.6
BDCA4+_DentriticCells5.2
Bonemarrow4.4
BronchialEpithelialCells4.35
CD105+_Endothelial4.55
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid6.5
CD34+5.75
CD4+_Tcells4.95
CD56+_NKCells5.4
CD71+_EarlyErythroid4.2
CD8+_Tcells4.4
CardiacMyocytes5.85
Caudatenucleus4.1
Cerebellum3.75
CerebellumPeduncles5.6
CiliaryGanglion5.75
CingulateCortex4.6
Colorectaladenocarcinoma4.5
DorsalRootGanglion3.55
FetalThyroid4.5
Fetalbrain4.5
Fetalliver3.95
Fetallung3.7
GlobusPallidus3.35
Heart5.95
Hypothalamus4.9
Kidney3.7
Leukemia_chronicMyelogenousK-5624.05
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.65
Liver8.3
Lung4.9
Lymphnode3.9
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.2
MedullaOblongata4.1
OccipitalLobe4.05
OlfactoryBulb3.55
Ovary3
Pancreas3.65
PancreaticIslet4.85
ParietalLobe4.75
Pituitary5.25
Placenta286.3
Pons4.35
PrefrontalCortex5.55
Prostate6.45
Salivarygland3.6
SkeletalMuscle6.7
Skin3.55
SmoothMuscle5.1
Spinalcord4.8
SubthalamicNucleus6.75
SuperiorCervicalGanglion5.7
TemporalLobe4.1
Testis3.85
TestisGermCell3.75
TestisIntersitial3.75
TestisLeydigCell4.4
TestisSeminiferousTubule3.85
Thalamus4.55
Thymus3.5
Thyroid5.65
Tongue4.4
Tonsil4.35
Trachea3.75
TrigeminalGanglion4.65
Uterus3.7
UterusCorpus4.2
WholeBlood4.9
Wholebrain3.75
colon4.45
pineal_day5.6
pineal_night5.44
retina5.35
small_intestine4.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14746_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.2 ± 1.03
Basal Forebrain1.49 ± 0.45
Basal Part of Pons1.45 ± 0.81
Cerebellar Cortex1.5 ± 0.79
Cerebellar Nuclei2.05 ± 0.92
Claustrum2.61 ± 0.84
Epithalamus1.43 ± 0.6
Frontal Lobe1.65 ± 0.8
Globus Pallidus2.4 ± 0.81
Hypothalamus1.78 ± 0.74
Insula1.66 ± 0.77
Limbic Lobe1.7 ± 0.81
Mesencephalon1.93 ± 0.78
Myelencephalon1.79 ± 0.76
Occipital Lobe1.79 ± 0.81
Parietal Lobe1.73 ± 0.83
Pontine Tegmentum1.65 ± 0.9
Striatum1.88 ± 0.79
Subthalamus1.62 ± 0.85
Temporal Lobe1.57 ± 0.89
Thalamus1.74 ± 0.73
White Matter2.16 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mmp11CBCerebellum1.79
2.49
Mmp11CTXCerebral cortex3.07
2.33
Mmp11HIPHippocampal region3.48
3.84
Mmp11HPFHippocampal formation3.03
3.02
Mmp11HYHypothalamus2.39
4.2
Mmp11LSXLateral septal complex0.02
0
Mmp11MBMidbrain0.55
1.23
Mmp11MYMedulla2.77
4.51
Mmp11OLFOlfactory bulb9.23
8.24
Mmp11PPons4.66
10.04
Mmp11PALPallidum0.54
0.56
Mmp11RHPRetrohippocampal region1.65
1.17
Mmp11sAMYStriatum-like amygdalar nuclei1.23
1.06
Mmp11STRStriatum1.5
1.64
Mmp11STRdStriatum dorsal region0.95
0.81
Mmp11STRvStriatum ventral region4.84
5.85
Mmp11THThalamus0.57
0.54
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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