AutismKB 2.0

Annotation Detail for MMP15


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Basic Information Top
Gene Symbol:MMP15 ( MT2-MMP,MTMMP2,SMCP-2 )
Gene Full Name: matrix metallopeptidase 15 (membrane-inserted)
Band: 16q21
Quick LinksEntrez ID:4324; OMIM: 602261; Uniprot ID:MMP15_HUMAN; ENSEMBL ID: ENSG00000102996; HGNC ID: 7161
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst7 / 62319112
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult60 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor18 / 119369150
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal88 / 336030726
ovarian tumor2 / 7668226
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer10 / 10268097
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites8 / 40015199
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye3 / 21105414
heart4 / 8962644
intestine7 / 23447229
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung15 / 33697444
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth0 / 670520 
muscle5 / 10771546
nerve3 / 15768190
ovary2 / 10205119
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate11 / 18934558
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach12 / 96619124
testis11 / 33044233
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203365_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.4
Adipocyte4.35
AdrenalCortex4.55
Adrenalgland3.7
Amygdala4.6
Appendix4.45
AtrioventricularNode3.35
BDCA4+_DentriticCells8.25
Bonemarrow4.35
BronchialEpithelialCells4.4
CD105+_Endothelial4.25
CD14+_Monocytes4.5
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid5.45
CD34+5.65
CD4+_Tcells4.9
CD56+_NKCells5.3
CD71+_EarlyErythroid4.2
CD8+_Tcells4.1
CardiacMyocytes5.6
Caudatenucleus3.95
Cerebellum3.55
CerebellumPeduncles5
CiliaryGanglion3.1
CingulateCortex5.35
Colorectaladenocarcinoma5
DorsalRootGanglion3.35
FetalThyroid39
Fetalbrain4.45
Fetalliver3.8
Fetallung6.75
GlobusPallidus3.25
Heart16.55
Hypothalamus4.8
Kidney3.55
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.9
Leukemialymphoblastic(MOLT-4)3.6
Liver12.2
Lung4.95
Lymphnode3.85
Lymphoma_burkitts(Daudi)5.55
Lymphoma_burkitts(Raji)6.2
MedullaOblongata3.75
OccipitalLobe4
OlfactoryBulb7.95
Ovary2.95
Pancreas4.15
PancreaticIslet4.7
ParietalLobe4.65
Pituitary5.2
Placenta32.6
Pons4.2
PrefrontalCortex5.55
Prostate5.2
Salivarygland3.5
SkeletalMuscle5.05
Skin3.4
SmoothMuscle4.9
Spinalcord4.9
SubthalamicNucleus4
SuperiorCervicalGanglion5.05
TemporalLobe4.35
Testis9.95
TestisGermCell41.65
TestisIntersitial4.4
TestisLeydigCell4.95
TestisSeminiferousTubule7.15
Thalamus7.45
Thymus3.4
Thyroid79.3
Tongue4.3
Tonsil4.35
Trachea3.55
TrigeminalGanglion4.35
Uterus3.45
UterusCorpus3.9
WholeBlood4.6
Wholebrain3.7
colon4.5
pineal_day5.48
pineal_night5.42
retina5.425
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P100177
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.1 ± 0.98
Basal Forebrain1.61 ± 0.21
Basal Part of Pons1.82 ± 0.75
Cerebellar Cortex1.79 ± 0.83
Cerebellar Nuclei2 ± 0.67
Claustrum2.47 ± 0.71
Epithalamus1.4 ± 0.73
Frontal Lobe1.7 ± 0.68
Globus Pallidus2.16 ± 0.3
Hypothalamus1.72 ± 0.57
Insula1.61 ± 0.34
Limbic Lobe1.71 ± 0.58
Mesencephalon1.88 ± 0.72
Myelencephalon1.83 ± 0.61
Occipital Lobe1.82 ± 0.53
Parietal Lobe1.81 ± 0.82
Pontine Tegmentum1.71 ± 0.62
Striatum1.76 ± 0.47
Subthalamus1.92 ± 0.67
Temporal Lobe1.67 ± 0.62
Thalamus2.03 ± 0.61
White Matter2.23 ± 0.4
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501489 39 569 607 WPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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