AutismKB 2.0

Annotation Detail for MMP16


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Basic Information Top
Gene Symbol:MMP16 ( C8orf57,DKFZp761D112,MMP-X2,MT-MMP2,MT-MMP3,MT3-MMP )
Gene Full Name: matrix metallopeptidase 16 (membrane-inserted)
Band: 8q21.3
Quick LinksEntrez ID:4325; OMIM: 602262; Uniprot ID:MMP16_HUMAN; ENSEMBL ID: ENSG00000156103; HGNC ID: 7162
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult5 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal37 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207013_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.3
Adipocyte7.25
AdrenalCortex8.95
Adrenalgland7.15
Amygdala8.45
Appendix8.2
AtrioventricularNode6.25
BDCA4+_DentriticCells6.45
Bonemarrow8.35
BronchialEpithelialCells6.7
CD105+_Endothelial7.45
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)7
CD33+_Myeloid8.2
CD34+8.5
CD4+_Tcells7.7
CD56+_NKCells7.95
CD71+_EarlyErythroid6.7
CD8+_Tcells7.1
CardiacMyocytes12.05
Caudatenucleus6.55
Cerebellum5.6
CerebellumPeduncles8.5
CiliaryGanglion8.5
CingulateCortex8.05
Colorectaladenocarcinoma7.4
DorsalRootGanglion8.75
FetalThyroid7.55
Fetalbrain7.3
Fetalliver6.15
Fetallung5.3
GlobusPallidus5.3
Heart12.15
Hypothalamus7.25
Kidney9.65
Leukemia_chronicMyelogenousK-5626.6
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)5.4
Liver10.35
Lung8.35
Lymphnode7.25
Lymphoma_burkitts(Daudi)10.75
Lymphoma_burkitts(Raji)11.8
MedullaOblongata8.15
OccipitalLobe8.85
OlfactoryBulb5.3
Ovary5.2
Pancreas5.85
PancreaticIslet7.9
ParietalLobe10.4
Pituitary11.6
Placenta8
Pons11.3
PrefrontalCortex8.45
Prostate8.35
Salivarygland6.35
SkeletalMuscle11.1
Skin7.55
SmoothMuscle8.35
Spinalcord7.7
SubthalamicNucleus7.5
SuperiorCervicalGanglion17.65
TemporalLobe8.35
Testis8.15
TestisGermCell5.55
TestisIntersitial6.2
TestisLeydigCell7.5
TestisSeminiferousTubule6.6
Thalamus7.4
Thymus5.65
Thyroid8.35
Tongue8.15
Tonsil10.9
Trachea6.9
TrigeminalGanglion10.65
Uterus5.95
UterusCorpus8.1
WholeBlood7.8
Wholebrain6
colon7.4
pineal_day9.2
pineal_night12.24
retina8.55
small_intestine6.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P216153
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.91 ± 0.46
Basal Forebrain5.25 ± 0.34
Basal Part of Pons4.63 ± 0.55
Cerebellar Cortex5.03 ± 0.33
Cerebellar Nuclei4.88 ± 0.45
Claustrum5 ± 0.76
Epithalamus4.51 ± 0.51
Frontal Lobe4.93 ± 0.48
Globus Pallidus4.55 ± 0.36
Hypothalamus4.84 ± 0.52
Insula5.16 ± 0.42
Limbic Lobe4.91 ± 0.47
Mesencephalon4.98 ± 0.47
Myelencephalon4.81 ± 0.56
Occipital Lobe4.79 ± 0.59
Parietal Lobe4.88 ± 0.56
Pontine Tegmentum4.89 ± 0.59
Striatum3.98 ± 0.56
Subthalamus4.57 ± 0.85
Temporal Lobe5.07 ± 0.36
Thalamus4.68 ± 0.57
White Matter3.96 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mmp16CBCerebellum24.77
25.3
Mmp16CTXCerebral cortex69.97
60.69
Mmp16HIPHippocampal region70.6
100
Mmp16HPFHippocampal formation70.88
95
Mmp16HYHypothalamus7.68
6.67
Mmp16LSXLateral septal complex18.95
13.67
Mmp16MBMidbrain26.44
25.45
Mmp16MYMedulla21.51
24.13
Mmp16OLFOlfactory bulb38.36
32.71
Mmp16PPons24.89
26.13
Mmp16PALPallidum30.1
35.03
Mmp16RHPRetrohippocampal region71.29
81.95
Mmp16sAMYStriatum-like amygdalar nuclei18.85
19.62
Mmp16STRStriatum21.48
18.8
Mmp16STRdStriatum dorsal region20.52
18.78
Mmp16STRvStriatum ventral region27.43
20.33
Mmp16THThalamus13.85
15.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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