AutismKB 2.0

Annotation Detail for MMP19


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Basic Information Top
Gene Symbol:MMP19 ( MMP18,RASI-1 )
Gene Full Name: matrix metallopeptidase 19
Band: 12q13.2
Quick LinksEntrez ID:4327; OMIM: 601807; Uniprot ID:MMP19_HUMAN; ENSEMBL ID: ENSG00000123342; HGNC ID: 7165
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus3 / 5640125
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult80 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal85 / 336030725
ovarian tumor5 / 7668265
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone4 / 7165555
bone marrow2 / 4880140
brain3 / 11009892
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye2 / 2110549
heart1 / 8962611
intestine13 / 23447255
kidney2 / 2117779
larynx1 / 2414541
liver2 / 2077439
lung24 / 33697471
lymph0 / 442700 
lymph node1 / 9161010
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary6 / 10205158
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta27 / 28082596
prostate2 / 18934510
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach3 / 9661931
testis1 / 3304423
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204574_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts42.5
Adipocyte77.55
AdrenalCortex80.8
Adrenalgland59.25
Amygdala62.8
Appendix112
AtrioventricularNode89.8
BDCA4+_DentriticCells70.55
Bonemarrow83.05
BronchialEpithelialCells44.6
CD105+_Endothelial66.05
CD14+_Monocytes63.45
CD19+_BCells(neg._sel.)77.2
CD33+_Myeloid83.45
CD34+89.3
CD4+_Tcells66.95
CD56+_NKCells85.3
CD71+_EarlyErythroid65
CD8+_Tcells40.9
CardiacMyocytes69.8
Caudatenucleus68.35
Cerebellum63.15
CerebellumPeduncles125.7
CiliaryGanglion59.55
CingulateCortex81.9
Colorectaladenocarcinoma66.4
DorsalRootGanglion88.1
FetalThyroid76.5
Fetalbrain83.9
Fetalliver57.25
Fetallung61.45
GlobusPallidus76.9
Heart87.1
Hypothalamus64.7
Kidney56.2
Leukemia_chronicMyelogenousK-56262.55
Leukemia_promyelocytic-HL-6061.25
Leukemialymphoblastic(MOLT-4)58.1
Liver92.4
Lung77.9
Lymphnode64.45
Lymphoma_burkitts(Daudi)89.5
Lymphoma_burkitts(Raji)95.9
MedullaOblongata76.1
OccipitalLobe69.15
OlfactoryBulb89.8
Ovary60.9
Pancreas54.25
PancreaticIslet73.05
ParietalLobe90.8
Pituitary85.4
Placenta64.1
Pons115.3
PrefrontalCortex68.75
Prostate85.7
Salivarygland56.65
SkeletalMuscle79.55
Skin109.6
SmoothMuscle70.85
Spinalcord75.6
SubthalamicNucleus108.65
SuperiorCervicalGanglion105.2
TemporalLobe85.5
Testis61.05
TestisGermCell66.6
TestisIntersitial59.1
TestisLeydigCell104.8
TestisSeminiferousTubule64.6
Thalamus76.9
Thymus55.1
Thyroid79.25
Tongue94.75
Tonsil72
Trachea74.8
TrigeminalGanglion156.3
Uterus57.3
UterusCorpus86.95
WholeBlood65.85
Wholebrain53.9
colon35.95
pineal_day54.4
pineal_night40.66
retina87.075
small_intestine36.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P203888
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.6 ± 0.63
Basal Forebrain4.21 ± 0.24
Basal Part of Pons4.39 ± 0.37
Cerebellar Cortex4.58 ± 0.51
Cerebellar Nuclei4.49 ± 0.51
Claustrum4.82 ± 0.71
Epithalamus3.93 ± 0.36
Frontal Lobe4.26 ± 0.65
Globus Pallidus4.6 ± 0.72
Hypothalamus4.22 ± 1.03
Insula4.33 ± 0.3
Limbic Lobe4.56 ± 0.57
Mesencephalon4.54 ± 0.57
Myelencephalon4.38 ± 0.61
Occipital Lobe4.53 ± 0.53
Parietal Lobe4.41 ± 0.62
Pontine Tegmentum4.29 ± 0.63
Striatum4.24 ± 0.56
Subthalamus4.12 ± 0.74
Temporal Lobe4.33 ± 0.62
Thalamus4.28 ± 0.57
White Matter4.83 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mmp19CBCerebellum0.78
1.3
Mmp19CTXCerebral cortex1.41
1.54
Mmp19HIPHippocampal region0.77
0.68
Mmp19HPFHippocampal formation0.87
0.68
Mmp19HYHypothalamus0.12
0.1
Mmp19LSXLateral septal complex0.1
0.05
Mmp19MBMidbrain0.34
0.45
Mmp19MYMedulla1.26
1.77
Mmp19OLFOlfactory bulb1.37
1.88
Mmp19PPons0.49
0.72
Mmp19PALPallidum0.47
0.47
Mmp19RHPRetrohippocampal region1.01
0.66
Mmp19sAMYStriatum-like amygdalar nuclei0.46
0.37
Mmp19STRStriatum0.53
0.41
Mmp19STRdStriatum dorsal region0.56
0.47
Mmp19STRvStriatum ventral region0.53
0.32
Mmp19THThalamus0.18
0.16
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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