AutismKB 2.0

Annotation Detail for ASL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ASL ( ASAL )
Gene Full Name: argininosuccinate lyase
Band: 7q11.21
Quick LinksEntrez ID:435; OMIM: 608310; Uniprot ID:ARLY_HUMAN; ENSEMBL ID: ENSG00000126522; HGNC ID: 746
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst7 / 62319112
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult115 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor25 / 119369209
germ cell tumor8 / 26384530
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia10 / 95842104
liver tumor19 / 96359197
lung tumor10 / 10312796
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal93 / 336030727
ovarian tumor1 / 7668213
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS40 / 125680318
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites15 / 40015374
bladder0 / 297570 
blood10 / 12347880
bone6 / 7165583
bone marrow1 / 4880120
brain30 / 110098927
cervix8 / 48171166
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye7 / 21105433
heart3 / 8962633
intestine20 / 23447285
kidney8 / 21177737
larynx0 / 241450 
liver22 / 207743105
lung19 / 33697456
lymph2 / 4427045
lymph node5 / 9161054
mammary gland4 / 15327126
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary7 / 10205168
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate6 / 18934531
salivary gland3 / 20155148
skin3 / 21057414
spleen4 / 5395274
stomach5 / 9661951
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204608_at
Cell line Expression level Expression bar
721_B_lymphoblasts152
Adipocyte12
AdrenalCortex9.3
Adrenalgland9
Amygdala10.85
Appendix10.95
AtrioventricularNode6.8
BDCA4+_DentriticCells12.05
Bonemarrow11.4
BronchialEpithelialCells17.1
CD105+_Endothelial16.1
CD14+_Monocytes21.4
CD19+_BCells(neg._sel.)13.1
CD33+_Myeloid29.1
CD34+14.85
CD4+_Tcells11.05
CD56+_NKCells30.3
CD71+_EarlyErythroid11.25
CD8+_Tcells10.3
CardiacMyocytes17.4
Caudatenucleus7.75
Cerebellum8.65
CerebellumPeduncles8.7
CiliaryGanglion6.2
CingulateCortex10
Colorectaladenocarcinoma18.15
DorsalRootGanglion8.2
FetalThyroid13.3
Fetalbrain5
Fetalliver39.55
Fetallung17.65
GlobusPallidus6.8
Heart25.45
Hypothalamus11.1
Kidney49.5
Leukemia_chronicMyelogenousK-5629.85
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)7.6
Liver1564.75
Lung126.95
Lymphnode8.25
Lymphoma_burkitts(Daudi)14.55
Lymphoma_burkitts(Raji)15.35
MedullaOblongata9.45
OccipitalLobe8.45
OlfactoryBulb8.45
Ovary7.1
Pancreas15.25
PancreaticIslet18.15
ParietalLobe11.05
Pituitary12.45
Placenta8.2
Pons10.15
PrefrontalCortex12.75
Prostate25
Salivarygland9.75
SkeletalMuscle13
Skin6.45
SmoothMuscle14.3
Spinalcord10.9
SubthalamicNucleus9.75
SuperiorCervicalGanglion9.6
TemporalLobe9.6
Testis6.1
TestisGermCell5.95
TestisIntersitial8.55
TestisLeydigCell7.55
TestisSeminiferousTubule7.95
Thalamus13.5
Thymus7.65
Thyroid57
Tongue10.4
Tonsil10.35
Trachea8.9
TrigeminalGanglion7
Uterus9.75
UterusCorpus9.65
WholeBlood11.85
Wholebrain17.3
colon70.35
pineal_day12.5
pineal_night14.26
retina14.325
small_intestine34.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7727_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.17 ± 0.49
Basal Forebrain5.51 ± 0.36
Basal Part of Pons5.41 ± 0.29
Cerebellar Cortex5.56 ± 0.21
Cerebellar Nuclei5.27 ± 0.33
Claustrum5.49 ± 0.46
Epithalamus5.3 ± 0.39
Frontal Lobe5.42 ± 0.38
Globus Pallidus5.44 ± 0.27
Hypothalamus5.7 ± 0.22
Insula5.42 ± 0.31
Limbic Lobe5.22 ± 0.45
Mesencephalon5.46 ± 0.4
Myelencephalon5.4 ± 0.38
Occipital Lobe5.09 ± 0.39
Parietal Lobe5.27 ± 0.44
Pontine Tegmentum5.14 ± 0.49
Striatum4.67 ± 0.31
Subthalamus5.62 ± 0.03
Temporal Lobe5.38 ± 0.39
Thalamus5.28 ± 0.37
White Matter5.52 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AslCBCerebellum3.2
2.78
AslCTXCerebral cortex3.28
1.03
AslHIPHippocampal region7.37
4.96
AslHPFHippocampal formation7.46
3.64
AslHYHypothalamus7.39
2.16
AslLSXLateral septal complex3.28
1.05
AslMBMidbrain10.77
3.98
AslMYMedulla8.97
4.39
AslOLFOlfactory bulb2.99
1.07
AslPPons9.89
4.97
AslPALPallidum3.19
1.1
AslRHPRetrohippocampal region7.87
2.03
AslsAMYStriatum-like amygdalar nuclei1.74
0.44
AslSTRStriatum1.08
0.42
AslSTRdStriatum dorsal region0.49
0.18
AslSTRvStriatum ventral region1.27
0.64
AslTHThalamus2.18
0.78
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARLY_HUMAN_58 12 58 69 AEMDQILHGLDK PRIDE
PAp00063164 12 58 69 AEMDQILHGLDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved