AutismKB 2.0

Annotation Detail for MRE11A


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Basic Information Top
Gene Symbol:MRE11A ( ATLD,HNGS1,MRE11,MRE11B )
Gene Full Name: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Band: 11q21
Quick LinksEntrez ID:4361; OMIM: 600814; Uniprot ID:MRE11_HUMAN; ENSEMBL ID: ENSG00000020922; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus22 / 56401239
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult53 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor2 / 17290115
gastrointestinal tumor1 / 1193698
germ cell tumor15 / 26384556
glioma2 / 10688318
head and neck tumor10 / 13630273
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal89 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone3 / 7165541
bone marrow2 / 4880140
brain13 / 110098911
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus2 / 2020998
eye4 / 21105418
heart0 / 896260 
intestine7 / 23447229
kidney5 / 21177723
larynx2 / 2414582
liver7 / 20774333
lung10 / 33697429
lymph0 / 442700 
lymph node5 / 9161054
mammary gland4 / 15327126
mouth7 / 67052104
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta10 / 28082535
prostate4 / 18934521
salivary gland0 / 201550 
skin6 / 21057428
spleen2 / 5395237
stomach1 / 9661910
testis7 / 33044221
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205395_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts55.05
Adipocyte6.1
AdrenalCortex7
Adrenalgland5.3
Amygdala6.3
Appendix7
AtrioventricularNode7.05
BDCA4+_DentriticCells19.45
Bonemarrow6.1
BronchialEpithelialCells5.95
CD105+_Endothelial26.3
CD14+_Monocytes9.05
CD19+_BCells(neg._sel.)10.15
CD33+_Myeloid15.2
CD34+25.6
CD4+_Tcells8.55
CD56+_NKCells24.2
CD71+_EarlyErythroid8.45
CD8+_Tcells21.55
CardiacMyocytes9.1
Caudatenucleus5.35
Cerebellum4.95
CerebellumPeduncles7.15
CiliaryGanglion5.35
CingulateCortex6.65
Colorectaladenocarcinoma6.4
DorsalRootGanglion6.2
FetalThyroid5.85
Fetalbrain5.75
Fetalliver5.7
Fetallung4.6
GlobusPallidus4.75
Heart9
Hypothalamus6.65
Kidney5.3
Leukemia_chronicMyelogenousK-56218.4
Leukemia_promyelocytic-HL-6022.45
Leukemialymphoblastic(MOLT-4)19.35
Liver8.7
Lung6.5
Lymphnode5.1
Lymphoma_burkitts(Daudi)38.9
Lymphoma_burkitts(Raji)9.05
MedullaOblongata5.3
OccipitalLobe5.4
OlfactoryBulb4.8
Ovary4.9
Pancreas5.45
PancreaticIslet6.6
ParietalLobe6.65
Pituitary7.3
Placenta5.95
Pons5.95
PrefrontalCortex7.45
Prostate7
Salivarygland5
SkeletalMuscle8.5
Skin5.6
SmoothMuscle6.9
Spinalcord6.5
SubthalamicNucleus5.75
SuperiorCervicalGanglion10.75
TemporalLobe5.7
Testis5.2
TestisGermCell4.9
TestisIntersitial5.15
TestisLeydigCell6.15
TestisSeminiferousTubule5.25
Thalamus6.3
Thymus4.55
Thyroid7.5
Tongue6.25
Tonsil6.65
Trachea5.15
TrigeminalGanglion6.7
Uterus4.85
UterusCorpus6.05
WholeBlood6.6
Wholebrain4.75
colon6.3
pineal_day7.4
pineal_night7.3
retina7.425
small_intestine5.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P169774
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.76 ± 1.06
Basal Forebrain2.17 ± 0.19
Basal Part of Pons1.93 ± 0.28
Cerebellar Cortex2.41 ± 0.76
Cerebellar Nuclei2.59 ± 0.76
Claustrum3.26 ± 0.88
Epithalamus2.01 ± 0.72
Frontal Lobe2.19 ± 0.62
Globus Pallidus2.8 ± 0.32
Hypothalamus2.35 ± 0.58
Insula2.27 ± 0.66
Limbic Lobe2.36 ± 0.61
Mesencephalon2.47 ± 0.62
Myelencephalon2.36 ± 0.69
Occipital Lobe2.53 ± 0.68
Parietal Lobe2.28 ± 0.61
Pontine Tegmentum2.43 ± 0.75
Striatum2.41 ± 0.51
Subthalamus2.45 ± 0.59
Temporal Lobe2.28 ± 0.72
Thalamus2.42 ± 0.78
White Matter2.69 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mre11aCBCerebellum6.04
6.82
Mre11aCTXCerebral cortex3.7
3.19
Mre11aHIPHippocampal region6.5
7.69
Mre11aHPFHippocampal formation5.88
6.05
Mre11aHYHypothalamus0.52
0.4
Mre11aLSXLateral septal complex1.95
1.91
Mre11aMBMidbrain2.33
2.43
Mre11aMYMedulla6.81
8.11
Mre11aOLFOlfactory bulb5.8
4.63
Mre11aPPons3.54
3.95
Mre11aPALPallidum1.79
2.1
Mre11aRHPRetrohippocampal region4.96
3.86
Mre11asAMYStriatum-like amygdalar nuclei0.87
1.12
Mre11aSTRStriatum2
1.83
Mre11aSTRdStriatum dorsal region2.11
2.03
Mre11aSTRvStriatum ventral region2.28
1.65
Mre11aTHThalamus1.31
1.08
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MRE11_HUMAN_306 22 306 327 QFFMEDIVLANHPDIFNPDNPK PRIDE
PAp00011707 10 71 80 TLHTCLELLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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