AutismKB 2.0

Annotation Detail for MSH3


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Basic Information Top
Gene Symbol:MSH3 ( DUP,MGC163306,MGC163308,MRP1 )
Gene Full Name: mutS homolog 3 (E. coli)
Band: 5q14.1
Quick LinksEntrez ID:4437; OMIM: 600887; Uniprot ID:MSH3_HUMAN; ENSEMBL ID: ENSG00000113318; HGNC ID: 7326
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus4 / 5640127
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal35 / 336030710
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow1 / 4880120
brain5 / 11009894
cervix1 / 4817120
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine1 / 2344724
kidney14 / 21177766
larynx0 / 241450 
liver4 / 20774319
lung1 / 3369742
lymph2 / 4427045
lymph node5 / 9161054
mammary gland2 / 15327113
mouth0 / 670520 
muscle5 / 10771546
nerve1 / 1576863
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate0 / 1893450 
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205887_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.15
Adipocyte29.05
AdrenalCortex65.3
Adrenalgland32.8
Amygdala53.05
Appendix51.85
AtrioventricularNode60.7
BDCA4+_DentriticCells23.05
Bonemarrow44.3
BronchialEpithelialCells24.3
CD105+_Endothelial32.95
CD14+_Monocytes39.45
CD19+_BCells(neg._sel.)30.15
CD33+_Myeloid43.8
CD34+34.95
CD4+_Tcells29.1
CD56+_NKCells32
CD71+_EarlyErythroid32.4
CD8+_Tcells23.3
CardiacMyocytes83.35
Caudatenucleus32.85
Cerebellum22.8
CerebellumPeduncles56.1
CiliaryGanglion46.4
CingulateCortex50.15
Colorectaladenocarcinoma29.65
DorsalRootGanglion43.2
FetalThyroid59.85
Fetalbrain32.8
Fetalliver24.35
Fetallung22.7
GlobusPallidus34.5
Heart59.3
Hypothalamus30.5
Kidney33.95
Leukemia_chronicMyelogenousK-56223.55
Leukemia_promyelocytic-HL-6024.1
Leukemialymphoblastic(MOLT-4)20.85
Liver47.75
Lung32.55
Lymphnode22.9
Lymphoma_burkitts(Daudi)45.35
Lymphoma_burkitts(Raji)51.2
MedullaOblongata32.55
OccipitalLobe42.5
OlfactoryBulb27.8
Ovary40.8
Pancreas35.1
PancreaticIslet36.15
ParietalLobe57.6
Pituitary38.85
Placenta27.3
Pons41.1
PrefrontalCortex43.85
Prostate54.85
Salivarygland30.1
SkeletalMuscle65.45
Skin45.8
SmoothMuscle36.95
Spinalcord27.35
SubthalamicNucleus45.95
SuperiorCervicalGanglion73.8
TemporalLobe35.9
Testis23.05
TestisGermCell26.05
TestisIntersitial47.2
TestisLeydigCell43.35
TestisSeminiferousTubule30
Thalamus37.35
Thymus23.9
Thyroid50.25
Tongue55.35
Tonsil37.55
Trachea25.45
TrigeminalGanglion77.5
Uterus24.85
UterusCorpus46.15
WholeBlood29.2
Wholebrain18.65
colon27.95
pineal_day52.82
pineal_night58.08
retina39.775
small_intestine25.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P203479
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.39 ± 0.31
Basal Forebrain7.49 ± 0.09
Basal Part of Pons7.38 ± 0.23
Cerebellar Cortex7.27 ± 0.23
Cerebellar Nuclei7.24 ± 0.25
Claustrum7.18 ± 0.38
Epithalamus7.57 ± 0.17
Frontal Lobe7.44 ± 0.26
Globus Pallidus7.6 ± 0.17
Hypothalamus7.38 ± 0.36
Insula7.48 ± 0.28
Limbic Lobe7.45 ± 0.35
Mesencephalon7.36 ± 0.34
Myelencephalon7.39 ± 0.33
Occipital Lobe7.21 ± 0.28
Parietal Lobe7.38 ± 0.25
Pontine Tegmentum7.38 ± 0.32
Striatum7.85 ± 0.21
Subthalamus7.4 ± 0.28
Temporal Lobe7.45 ± 0.27
Thalamus7.32 ± 0.21
White Matter7.72 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Msh3CBCerebellum27.79
29.34
Msh3CTXCerebral cortex40.57
33.05
Msh3HIPHippocampal region36.66
45.25
Msh3HPFHippocampal formation36.73
38.56
Msh3HYHypothalamus9.09
7.53
Msh3LSXLateral septal complex43.9
35.17
Msh3MBMidbrain17.74
17.87
Msh3MYMedulla27.32
30.16
Msh3OLFOlfactory bulb42.91
35.43
Msh3PPons19.61
21.89
Msh3PALPallidum13.52
12.55
Msh3RHPRetrohippocampal region36.82
30.26
Msh3sAMYStriatum-like amygdalar nuclei20.49
14.3
Msh3STRStriatum34.88
25.72
Msh3STRdStriatum dorsal region32.33
23.77
Msh3STRvStriatum ventral region50.62
36.01
Msh3THThalamus11.72
10.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042304 17 4 20 RKPASGGLAASSSAPAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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