AutismKB 2.0

Annotation Detail for MTNR1B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MTNR1B ( FGQTL2,MEL-1B-R,MT2 )
Gene Full Name: melatonin receptor 1B
Band: 11q14.3
Quick LinksEntrez ID:4544; OMIM: 600804; Uniprot ID:MTR1B_HUMAN; ENSEMBL ID: ENSG00000134640; HGNC ID: 7464
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208516_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.95
Adipocyte3.1
AdrenalCortex3.25
Adrenalgland2.65
Amygdala3.3
Appendix3.1
AtrioventricularNode2.4
BDCA4+_DentriticCells3.5
Bonemarrow3.05
BronchialEpithelialCells3.1
CD105+_Endothelial3.15
CD14+_Monocytes3.4
CD19+_BCells(neg._sel.)3.35
CD33+_Myeloid4
CD34+3.95
CD4+_Tcells3.45
CD56+_NKCells3.75
CD71+_EarlyErythroid2.9
CD8+_Tcells3.05
CardiacMyocytes3.95
Caudatenucleus2.8
Cerebellum2.5
CerebellumPeduncles3.5
CiliaryGanglion2.15
CingulateCortex3.2
Colorectaladenocarcinoma3.15
DorsalRootGanglion2.4
FetalThyroid3.05
Fetalbrain3.15
Fetalliver2.7
Fetallung2.65
GlobusPallidus2.3
Heart4
Hypothalamus3.45
Kidney2.5
Leukemia_chronicMyelogenousK-5622.85
Leukemia_promyelocytic-HL-602.75
Leukemialymphoblastic(MOLT-4)2.55
Liver4.05
Lung3.5
Lymphnode2.7
Lymphoma_burkitts(Daudi)3.95
Lymphoma_burkitts(Raji)4.3
MedullaOblongata2.85
OccipitalLobe2.8
OlfactoryBulb2.5
Ovary2.05
Pancreas2.5
PancreaticIslet3.35
ParietalLobe3.25
Pituitary3.65
Placenta3.25
Pons2.95
PrefrontalCortex3.9
Prostate3.7
Salivarygland2.5
SkeletalMuscle3.65
Skin2.35
SmoothMuscle3.6
Spinalcord3.3
SubthalamicNucleus2.85
SuperiorCervicalGanglion3.5
TemporalLobe2.85
Testis2.7
TestisGermCell2.65
TestisIntersitial2.6
TestisLeydigCell3.1
TestisSeminiferousTubule2.65
Thalamus3.15
Thymus2.5
Thyroid3.9
Tongue3.05
Tonsil3.05
Trachea2.6
TrigeminalGanglion3.1
Uterus2.55
UterusCorpus2.8
WholeBlood3.45
Wholebrain2.7
colon3.15
pineal_day3.96
pineal_night3.82
retina3.8
small_intestine3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14335_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.5 ± 1.2
Basal Forebrain2.27 ± 0.52
Basal Part of Pons1.78 ± 0.64
Cerebellar Cortex1.89 ± 0.85
Cerebellar Nuclei2.29 ± 0.6
Claustrum2.95 ± 1.07
Epithalamus1.71 ± 0.93
Frontal Lobe1.95 ± 0.91
Globus Pallidus2.62 ± 0.64
Hypothalamus1.99 ± 0.77
Insula1.94 ± 0.89
Limbic Lobe2.01 ± 0.82
Mesencephalon2.24 ± 0.78
Myelencephalon2.12 ± 0.79
Occipital Lobe2.07 ± 0.62
Parietal Lobe1.99 ± 0.74
Pontine Tegmentum2.23 ± 0.85
Striatum2.61 ± 0.73
Subthalamus2.32 ± 0.71
Temporal Lobe2.05 ± 0.79
Thalamus2.07 ± 0.73
White Matter2.48 ± 0.41
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018