AutismKB 2.0

Annotation Detail for MTTP


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Basic Information Top
Gene Symbol:MTTP ( ABL,MGC149819,MGC149820,MTP )
Gene Full Name: microsomal triglyceride transfer protein
Band: 4q23
Quick LinksEntrez ID:4547; OMIM: 157147; Uniprot ID:MTP_HUMAN; ENSEMBL ID: ENSG00000138823; HGNC ID: 7467
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus17 / 56401230
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult9 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor11 / 96359114
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal52 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine10 / 23447242
kidney10 / 21177747
larynx0 / 241450 
liver21 / 207743101
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis24 / 33044272
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205675_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.7
Adipocyte8.25
AdrenalCortex10.9
Adrenalgland7.35
Amygdala7.7
Appendix11
AtrioventricularNode9.05
BDCA4+_DentriticCells8.4
Bonemarrow9.5
BronchialEpithelialCells7.6
CD105+_Endothelial8.4
CD14+_Monocytes8.7
CD19+_BCells(neg._sel.)8.45
CD33+_Myeloid11.1
CD34+10.2
CD4+_Tcells8.15
CD56+_NKCells9.25
CD71+_EarlyErythroid7.9
CD8+_Tcells6.95
CardiacMyocytes12.6
Caudatenucleus7.45
Cerebellum6.75
CerebellumPeduncles10.45
CiliaryGanglion8.45
CingulateCortex8.75
Colorectaladenocarcinoma8.1
DorsalRootGanglion7.75
FetalThyroid8.35
Fetalbrain8.35
Fetalliver65.55
Fetallung6.6
GlobusPallidus6.75
Heart16.75
Hypothalamus8.55
Kidney8.15
Leukemia_chronicMyelogenousK-5627.45
Leukemia_promyelocytic-HL-607.2
Leukemialymphoblastic(MOLT-4)6.7
Liver31.3
Lung8.9
Lymphnode7.05
Lymphoma_burkitts(Daudi)11.2
Lymphoma_burkitts(Raji)12.4
MedullaOblongata7.85
OccipitalLobe7.3
OlfactoryBulb6.25
Ovary6.7
Pancreas7.05
PancreaticIslet9
ParietalLobe9.35
Pituitary9.75
Placenta7.8
Pons8.35
PrefrontalCortex9.5
Prostate9.55
Salivarygland6.9
SkeletalMuscle14.15
Skin9.1
SmoothMuscle9.25
Spinalcord8.95
SubthalamicNucleus7.8
SuperiorCervicalGanglion12.85
TemporalLobe7.9
Testis7.1
TestisGermCell7
TestisIntersitial7.35
TestisLeydigCell8.9
TestisSeminiferousTubule7.05
Thalamus8.6
Thymus6.15
Thyroid9.75
Tongue9.4
Tonsil8.3
Trachea6.9
TrigeminalGanglion10.35
Uterus6.45
UterusCorpus8.1
WholeBlood8.8
Wholebrain6.15
colon8.25
pineal_day9.82
pineal_night9.7
retina9.7
small_intestine1226
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_288_PI417507815
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.78 ± 0.8
Basal Forebrain3.43 ± 0.55
Basal Part of Pons3.86 ± 0.45
Cerebellar Cortex3.25 ± 0.57
Cerebellar Nuclei3.38 ± 0.62
Claustrum4.14 ± 0.56
Epithalamus5.8 ± 0.43
Frontal Lobe4.09 ± 0.73
Globus Pallidus4.85 ± 0.55
Hypothalamus4.16 ± 0.77
Insula3.5 ± 0.79
Limbic Lobe3.59 ± 0.74
Mesencephalon3.95 ± 0.82
Myelencephalon3.85 ± 0.75
Occipital Lobe3.82 ± 0.61
Parietal Lobe3.71 ± 0.79
Pontine Tegmentum3.83 ± 0.77
Striatum3.59 ± 1.04
Subthalamus3.47 ± 0.24
Temporal Lobe3.58 ± 0.68
Thalamus4.16 ± 0.47
White Matter4.71 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MttpCBCerebellum12.18
19.24
MttpCTXCerebral cortex31.43
23.38
MttpHIPHippocampal region15.78
23.12
MttpHPFHippocampal formation17.58
20.4
MttpHYHypothalamus43.64
35.56
MttpLSXLateral septal complex60.92
46.18
MttpMBMidbrain17.03
19.05
MttpMYMedulla8.69
10.96
MttpOLFOlfactory bulb27.73
22.24
MttpPPons15.05
18.25
MttpPALPallidum44.92
39.53
MttpRHPRetrohippocampal region21.85
16.49
MttpsAMYStriatum-like amygdalar nuclei37.41
27.91
MttpSTRStriatum28.26
22.77
MttpSTRdStriatum dorsal region19.95
17.69
MttpSTRvStriatum ventral region40.28
28.34
MttpTHThalamus32.9
32.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MTP_HUMAN_540 33 540 572 TAAAAIILNNNPSYMDVKNILLSIGELPQEMNK PRIDE
PAp00002244 20 860 879 ESVLAGCEFPLHQENSEMCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018