AutismKB 2.0

Annotation Detail for GADD45B


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Basic Information Top
Gene Symbol:GADD45B ( DKFZp566B133,GADD45BETA,MYD118 )
Gene Full Name: growth arrest and DNA-damage-inducible, beta
Band: 19p13.3
Quick LinksEntrez ID:4616; OMIM: 604948; Uniprot ID:GA45B_HUMAN; ENSEMBL ID: ENSG00000099860; HGNC ID: 4096
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst1 / 6231916
fetus36 / 56401263
neonate1 / 3109732
infant1 / 2362042
juvenile4 / 5555671
adult148 / 193912176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma14 / 82823169
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor207 / 1193691734
germ cell tumor0 / 2638450 
glioma13 / 106883121
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor6 / 9635962
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal287 / 336030785
ovarian tumor17 / 76682221
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland3 / 3319790
ascites206 / 400155148
bladder0 / 297570 
blood6 / 12347848
bone12 / 71655167
bone marrow5 / 48801102
brain68 / 110098961
cervix0 / 481710 
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye18 / 21105485
heart6 / 8962666
intestine20 / 23447285
kidney19 / 21177789
larynx0 / 241450 
liver20 / 20774396
lung68 / 336974201
lymph1 / 4427022
lymph node14 / 91610152
mammary gland7 / 15327145
mouth0 / 670520 
muscle5 / 10771546
nerve1 / 1576863
ovary19 / 102051186
pancreas17 / 21481279
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta12 / 28082542
prostate5 / 18934526
salivary gland0 / 201550 
skin12 / 21057456
spleen7 / 53952129
stomach0 / 966190 
testis1 / 3304423
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207574_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts314.75
Adipocyte206.7
AdrenalCortex267.45
Adrenalgland143.9
Amygdala99.1
Appendix266.3
AtrioventricularNode190.1
BDCA4+_DentriticCells417.2
Bonemarrow299.5
BronchialEpithelialCells33
CD105+_Endothelial38.25
CD14+_Monocytes456.8
CD19+_BCells(neg._sel.)256.25
CD33+_Myeloid364.95
CD34+37.45
CD4+_Tcells177.15
CD56+_NKCells404.35
CD71+_EarlyErythroid10.5
CD8+_Tcells165.3
CardiacMyocytes45.7
Caudatenucleus45.15
Cerebellum54.6
CerebellumPeduncles119.25
CiliaryGanglion299.45
CingulateCortex56.1
Colorectaladenocarcinoma82.85
DorsalRootGanglion54.6
FetalThyroid806.1
Fetalbrain76.2
Fetalliver19.5
Fetallung435.7
GlobusPallidus19.7
Heart340.6
Hypothalamus255.9
Kidney159.9
Leukemia_chronicMyelogenousK-56210.1
Leukemia_promyelocytic-HL-6057.75
Leukemialymphoblastic(MOLT-4)8.25
Liver290.3
Lung2274.4
Lymphnode134.65
Lymphoma_burkitts(Daudi)104.95
Lymphoma_burkitts(Raji)979.4
MedullaOblongata42.35
OccipitalLobe50.15
OlfactoryBulb836.35
Ovary263.65
Pancreas142.45
PancreaticIslet682.45
ParietalLobe43.4
Pituitary226.45
Placenta226.4
Pons17.6
PrefrontalCortex115.9
Prostate463.45
Salivarygland35
SkeletalMuscle175.4
Skin203.35
SmoothMuscle88.2
Spinalcord421.1
SubthalamicNucleus65.85
SuperiorCervicalGanglion100.95
TemporalLobe80.25
Testis37.3
TestisGermCell99.35
TestisIntersitial21.25
TestisLeydigCell13.4
TestisSeminiferousTubule16.85
Thalamus93.45
Thymus196.6
Thyroid928.35
Tongue50.25
Tonsil43.5
Trachea198.9
TrigeminalGanglion419.8
Uterus142.15
UterusCorpus65.35
WholeBlood291.85
Wholebrain85.5
colon80.35
pineal_day81.02
pineal_night96.16
retina646.7
small_intestine96.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P142506
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.99 ± 0.39
Basal Forebrain6.11 ± 0.2
Basal Part of Pons6.71 ± 0.56
Cerebellar Cortex6.4 ± 0.39
Cerebellar Nuclei6.62 ± 0.35
Claustrum6.76 ± 0.48
Epithalamus7.76 ± 0.48
Frontal Lobe6.3 ± 0.51
Globus Pallidus7.73 ± 0.41
Hypothalamus6.52 ± 1.25
Insula6.14 ± 0.28
Limbic Lobe6.11 ± 0.44
Mesencephalon6.49 ± 0.44
Myelencephalon6.4 ± 0.56
Occipital Lobe6.7 ± 0.4
Parietal Lobe6.41 ± 0.44
Pontine Tegmentum6.35 ± 0.38
Striatum7.04 ± 0.55
Subthalamus6.45 ± 0.25
Temporal Lobe6.2 ± 0.43
Thalamus6.61 ± 0.29
White Matter6.36 ± 0.78
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gadd45bCBCerebellum18.37
21.46
Gadd45bCTXCerebral cortex46.24
34.3
Gadd45bHIPHippocampal region17.13
19.82
Gadd45bHPFHippocampal formation18.17
16.39
Gadd45bHYHypothalamus14.41
6.94
Gadd45bLSXLateral septal complex12.86
7.22
Gadd45bMBMidbrain25.95
18.96
Gadd45bMYMedulla19.93
15.4
Gadd45bOLFOlfactory bulb32.79
21.73
Gadd45bPPons17.67
12.68
Gadd45bPALPallidum10.11
5.14
Gadd45bRHPRetrohippocampal region20.26
12.15
Gadd45bsAMYStriatum-like amygdalar nuclei14.97
7.49
Gadd45bSTRStriatum18.27
8.71
Gadd45bSTRdStriatum dorsal region18.33
8.49
Gadd45bSTRvStriatum ventral region22.99
10.99
Gadd45bTHThalamus18.31
9.86
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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