AutismKB 2.0

Annotation Detail for MYH11


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Basic Information Top
Gene Symbol:MYH11 ( AAT4,DKFZp686D10126,DKFZp686D19237,FAA4,FLJ35232,MGC126726,MGC32963,SMHC,SMMHC )
Gene Full Name: myosin, heavy chain 11, smooth muscle
Band: 16p13.11
Quick LinksEntrez ID:4629; OMIM: 160745; Uniprot ID:MYH11_HUMAN; ENSEMBL ID: ENSG00000133392; HGNC ID: 7569
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus37 / 56401265
neonate0 / 310970 
infant3 / 23620127
juvenile2 / 5555635
adult759 / 1939121391
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor19 / 94178201
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor65 / 114246568
esophageal tumor2 / 17290115
gastrointestinal tumor35 / 119369293
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor27 / 136302198
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor11 / 103127106
lymphoma7 / 7175597
non-neoplasia4 / 9725041
normal783 / 3360307233
ovarian tumor3 / 7668239
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer47 / 102680457
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor19 / 90257210
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder3 / 29757100
blood2 / 12347816
bone0 / 716550 
bone marrow3 / 4880161
brain50 / 110098945
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus3 / 20209148
eye51 / 211054241
heart8 / 8962689
intestine225 / 234472959
kidney21 / 21177799
larynx18 / 24145745
liver5 / 20774324
lung48 / 336974142
lymph6 / 44270135
lymph node8 / 9161087
mammary gland40 / 153271260
mouth4 / 6705259
muscle48 / 107715445
nerve2 / 15768126
ovary5 / 10205148
pancreas16 / 21481274
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland4 / 16585241
placenta26 / 28082592
prostate265 / 1893451399
salivary gland0 / 201550 
skin0 / 2105740 
spleen7 / 53952129
stomach55 / 96619569
testis59 / 330442178
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea20 / 52413381
umbilical cord0 / 136800 
uterus130 / 232878558
vascular13 / 51780251
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207961_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.65
Adipocyte6.25
AdrenalCortex12.35
Adrenalgland26.3
Amygdala18.05
Appendix540.85
AtrioventricularNode15.1
BDCA4+_DentriticCells6.85
Bonemarrow8.8
BronchialEpithelialCells6.25
CD105+_Endothelial6.2
CD14+_Monocytes8.7
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid10.55
CD34+8
CD4+_Tcells7.4
CD56+_NKCells6.95
CD71+_EarlyErythroid8.95
CD8+_Tcells5.95
CardiacMyocytes10.75
Caudatenucleus6.6
Cerebellum6
CerebellumPeduncles8.15
CiliaryGanglion47.65
CingulateCortex6.3
Colorectaladenocarcinoma6.3
DorsalRootGanglion8.65
FetalThyroid14.45
Fetalbrain6.7
Fetalliver9.15
Fetallung73.7
GlobusPallidus5.1
Heart37.15
Hypothalamus10.55
Kidney8.2
Leukemia_chronicMyelogenousK-5626.75
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.9
Liver14.55
Lung144.4
Lymphnode56.3
Lymphoma_burkitts(Daudi)8.85
Lymphoma_burkitts(Raji)13.35
MedullaOblongata6.65
OccipitalLobe6.75
OlfactoryBulb43.5
Ovary96.85
Pancreas8.35
PancreaticIslet8.8
ParietalLobe7.05
Pituitary19.2
Placenta80.35
Pons5.8
PrefrontalCortex10.4
Prostate507.3
Salivarygland29.75
SkeletalMuscle8.4
Skin17.6
SmoothMuscle8.15
Spinalcord22.6
SubthalamicNucleus7.5
SuperiorCervicalGanglion12.95
TemporalLobe6.55
Testis42.4
TestisGermCell335.75
TestisIntersitial45.75
TestisLeydigCell157.65
TestisSeminiferousTubule61.5
Thalamus9.4
Thymus15.7
Thyroid67.05
Tongue8.3
Tonsil6.4
Trachea130.3
TrigeminalGanglion25.15
Uterus605.7
UterusCorpus169.5
WholeBlood6.7
Wholebrain6.45
colon406.85
pineal_day9.9
pineal_night8.52
retina264.05
small_intestine236.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12192_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.48 ± 1.12
Basal Forebrain3.18 ± 0.86
Basal Part of Pons3.64 ± 0.95
Cerebellar Cortex3.06 ± 1.09
Cerebellar Nuclei4.69 ± 0.81
Claustrum2.88 ± 0.98
Epithalamus2.85 ± 1.04
Frontal Lobe3.81 ± 1.27
Globus Pallidus5.26 ± 0.76
Hypothalamus3.54 ± 1.1
Insula4.26 ± 0.84
Limbic Lobe3.55 ± 1.22
Mesencephalon4.17 ± 1.01
Myelencephalon3.89 ± 1.1
Occipital Lobe3.81 ± 1.1
Parietal Lobe3.58 ± 1.23
Pontine Tegmentum4.01 ± 1.3
Striatum4.62 ± 0.96
Subthalamus4.25 ± 0.85
Temporal Lobe3.83 ± 1.16
Thalamus4.43 ± 0.81
White Matter3.39 ± 0.77
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Myh11CBCerebellum100
100
Myh11CTXCerebral cortex100
100
Myh11HIPHippocampal region100
100
Myh11HPFHippocampal formation100
100
Myh11HYHypothalamus100
100
Myh11LSXLateral septal complex100
100
Myh11MBMidbrain100
100
Myh11MYMedulla100
100
Myh11OLFOlfactory bulb100
100
Myh11PPons100
100
Myh11PALPallidum100
100
Myh11RHPRetrohippocampal region100
100
Myh11sAMYStriatum-like amygdalar nuclei100
100
Myh11STRStriatum100
100
Myh11STRdStriatum dorsal region100
100
Myh11STRvStriatum ventral region100
100
Myh11THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MYH11_HUMAN_1008 14 1008 1021 ISDLTTNLAEEEEK PRIDE
MYH11_HUMAN_1082 16 1082 1097 MQLAKKEEELQAALAR PRIDE
MYH11_HUMAN_1087 11 1087 1097 KEEELQAALAR PRIDE
MYH11_HUMAN_1201 17 1201 1217 HAQAVEELTEQLEQFKR PRIDE
MYH11_HUMAN_1309 21 1309 1329 DVASLSSQLQDTQELLQEETR PRIDE
MYH11_HUMAN_1346 14 1346 1359 NSLQDQLDEEMEAK PRIDE
MYH11_HUMAN_1380 15 1380 1394 LQDFASTVEALEEGK PRIDE
MYH11_HUMAN_1400 12 1400 1411 EIENLTQQYEEK PRIDE
MYH11_HUMAN_1425 16 1425 1440 LQQELDDLVVDLDNQR PRIDE
MYH11_HUMAN_1451 10 1451 1460 KFDQLLAEEK PRIDE
MYH11_HUMAN_1452 9 1452 1460 FDQLLAEEK PRIDE
MYH11_HUMAN_1545 17 1545 1561 TQLEELEDELQATEDAK PRIDE
MYH11_HUMAN_169 15 169 183 EDQSILCTGESGAGK PRIDE
MYH11_HUMAN_169 20 169 188 EDQSILCTGESGAGKTENTK PRIDE
MYH11_HUMAN_169 21 169 189 EDQSILCTGESGAGKTENTKK PRIDE
MYH11_HUMAN_1793 6 1793 1798 QNKELR PRIDE
MYH11_HUMAN_1823 13 1823 1835 IAQLEEQVEQEAR PRIDE
MYH11_HUMAN_216 16 216 231 QLLQANPILEAFGNAK PRIDE
MYH11_HUMAN_349 14 349 362 VVSSVLQLGNIVFK PRIDE
MYH11_HUMAN_365 15 365 379 NTDQASMPDNTAAQK PRIDE
MYH11_HUMAN_415 12 415 426 EQADFAVEALAK PRIDE
MYH11_HUMAN_719 7 719 725 IVFQEFR PRIDE
MYH11_HUMAN_753 10 753 762 ALELDPNLYR PRIDE
MYH11_HUMAN_772 11 772 782 TGVLAHLEEER PRIDE
PAp00001228 9 701 709 CNGVLEGIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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