AutismKB 2.0

Annotation Detail for MYO6


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Basic Information Top
Gene Symbol:MYO6 ( DFNA22,DFNB37,KIAA0389 )
Gene Full Name: myosin VI
Band: 6q14.1
Quick LinksEntrez ID:4646; OMIM: 600970; Uniprot ID:MYO6_HUMAN; ENSEMBL ID: ENSG00000196586; HGNC ID: 7605
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst1 / 6231916
fetus17 / 56401230
neonate1 / 3109732
infant1 / 2362042
juvenile3 / 5555653
adult176 / 193912190
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor13 / 94178138
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor9 / 13630266
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia14 / 97250143
normal200 / 336030759
ovarian tumor8 / 76682104
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer56 / 102680545
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder1 / 2975733
blood1 / 1234788
bone5 / 7165569
bone marrow1 / 4880120
brain58 / 110098952
cervix0 / 481710 
connective tissue4 / 14925526
ear4 / 16212246
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye17 / 21105480
heart1 / 8962611
intestine10 / 23447242
kidney23 / 211777108
larynx0 / 241450 
liver5 / 20774324
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland23 / 153271150
mouth6 / 6705289
muscle11 / 107715102
nerve2 / 15768126
ovary8 / 10205178
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta3 / 28082510
prostate68 / 189345359
salivary gland1 / 2015549
skin5 / 21057423
spleen2 / 5395237
stomach7 / 9661972
testis32 / 33044296
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus18 / 23287877
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203216_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts176.15
Adipocyte7.3
AdrenalCortex8.85
Adrenalgland6.45
Amygdala84.2
Appendix9.25
AtrioventricularNode7.15
BDCA4+_DentriticCells7.1
Bonemarrow7.6
BronchialEpithelialCells19.8
CD105+_Endothelial7.3
CD14+_Monocytes7.95
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid9
CD34+8.6
CD4+_Tcells7.4
CD56+_NKCells8.25
CD71+_EarlyErythroid6.7
CD8+_Tcells6.5
CardiacMyocytes11.25
Caudatenucleus25.9
Cerebellum6.25
CerebellumPeduncles9.1
CiliaryGanglion7
CingulateCortex8.4
Colorectaladenocarcinoma7.8
DorsalRootGanglion6.7
FetalThyroid7.7
Fetalbrain7.7
Fetalliver6.6
Fetallung36.75
GlobusPallidus6.05
Heart10.7
Hypothalamus49.5
Kidney11.1
Leukemia_chronicMyelogenousK-5626.95
Leukemia_promyelocytic-HL-606.3
Leukemialymphoblastic(MOLT-4)5.35
Liver10.45
Lung8.25
Lymphnode6.1
Lymphoma_burkitts(Daudi)10.15
Lymphoma_burkitts(Raji)10.8
MedullaOblongata7.4
OccipitalLobe14.95
OlfactoryBulb6.4
Ovary5.25
Pancreas23.45
PancreaticIslet34.85
ParietalLobe8.85
Pituitary19.8
Placenta7.3
Pons7.55
PrefrontalCortex80.6
Prostate14.55
Salivarygland13.65
SkeletalMuscle9.9
Skin6.75
SmoothMuscle9
Spinalcord32.05
SubthalamicNucleus7.35
SuperiorCervicalGanglion10.55
TemporalLobe7.2
Testis6.9
TestisGermCell41.85
TestisIntersitial8.35
TestisLeydigCell7.9
TestisSeminiferousTubule14.4
Thalamus13.85
Thymus5.25
Thyroid21.8
Tongue8.15
Tonsil7.75
Trachea7.25
TrigeminalGanglion8.65
Uterus7
UterusCorpus7.3
WholeBlood7.6
Wholebrain13.5
colon46.75
pineal_day601.88
pineal_night654.32
retina32.35
small_intestine56.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P283225
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.98 ± 0.33
Basal Forebrain8.33 ± 0.15
Basal Part of Pons7.87 ± 0.5
Cerebellar Cortex7.91 ± 0.19
Cerebellar Nuclei8.28 ± 0.42
Claustrum7.73 ± 0.5
Epithalamus8.42 ± 0.5
Frontal Lobe8.07 ± 0.38
Globus Pallidus8.84 ± 0.18
Hypothalamus7.95 ± 0.31
Insula8.01 ± 0.18
Limbic Lobe7.99 ± 0.36
Mesencephalon8.17 ± 0.41
Myelencephalon8.16 ± 0.42
Occipital Lobe8.41 ± 0.38
Parietal Lobe8.12 ± 0.33
Pontine Tegmentum8.2 ± 0.36
Striatum8.64 ± 0.29
Subthalamus8.29 ± 0.07
Temporal Lobe8.03 ± 0.28
Thalamus8.28 ± 0.38
White Matter9.83 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Myo6CBCerebellum4.22
5.38
Myo6CTXCerebral cortex3.3
4.17
Myo6HIPHippocampal region2.08
2.48
Myo6HPFHippocampal formation2.12
2.14
Myo6HYHypothalamus0.76
0.56
Myo6LSXLateral septal complex0.63
0.35
Myo6MBMidbrain2.86
2.75
Myo6MYMedulla7.39
7.19
Myo6OLFOlfactory bulb2.96
2.52
Myo6PPons3.8
3.62
Myo6PALPallidum2.09
1.59
Myo6RHPRetrohippocampal region2.31
1.57
Myo6sAMYStriatum-like amygdalar nuclei0.54
0.59
Myo6STRStriatum1.66
1.28
Myo6STRdStriatum dorsal region2.27
1.77
Myo6STRvStriatum ventral region1.03
0.73
Myo6THThalamus4
3.31
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MYO6_HUMAN_142 20 142 161 MSQSIIVSGESGAGKTENTK PRIDE
MYO6_HUMAN_980 11 980 990 IQAEVEAQLAR PRIDE
PAp00001011 14 1256 1269 CGGIQYLQNAIESR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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