AutismKB 2.0

Annotation Detail for PPP1R12B


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Basic Information Top
Gene Symbol:PPP1R12B ( FLJ40942,MGC131980,MGC87886,MYPT2 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 12B
Band: 1q32.1
Quick LinksEntrez ID:4660; OMIM: 603768; Uniprot ID:MYPT2_HUMAN; ENSEMBL ID: ENSG00000077157; HGNC ID: 7619
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus76 / 564012134
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult194 / 1939121100
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor6 / 11936950
germ cell tumor4 / 26384515
glioma6 / 10688356
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal333 / 336030799
ovarian tumor6 / 7668278
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer17 / 102680165
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain78 / 110098970
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus3 / 20209148
eye20 / 21105494
heart29 / 89626323
intestine18 / 23447276
kidney8 / 21177737
larynx2 / 2414582
liver11 / 20774352
lung16 / 33697447
lymph0 / 442700 
lymph node1 / 9161010
mammary gland15 / 15327197
mouth4 / 6705259
muscle28 / 107715259
nerve4 / 15768253
ovary5 / 10205148
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta16 / 28082556
prostate43 / 189345227
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach10 / 96619103
testis10 / 33044230
thymus9 / 81131110
thyroid1 / 4747321
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus29 / 232878124
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201958_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte3.65
AdrenalCortex3.85
Adrenalgland3.1
Amygdala3.9
Appendix3.65
AtrioventricularNode2.8
BDCA4+_DentriticCells4.05
Bonemarrow3.65
BronchialEpithelialCells3.65
CD105+_Endothelial3.7
CD14+_Monocytes3.9
CD19+_BCells(neg._sel.)3.95
CD33+_Myeloid4.8
CD34+4.75
CD4+_Tcells4.05
CD56+_NKCells4.4
CD71+_EarlyErythroid3.45
CD8+_Tcells3.6
CardiacMyocytes4.65
Caudatenucleus3.35
Cerebellum3
CerebellumPeduncles4.15
CiliaryGanglion2.55
CingulateCortex3.75
Colorectaladenocarcinoma3.7
DorsalRootGanglion2.85
FetalThyroid3.55
Fetalbrain3.7
Fetalliver3.15
Fetallung3.1
GlobusPallidus2.7
Heart4.65
Hypothalamus4.05
Kidney3
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)3
Liver4.85
Lung4
Lymphnode3.2
Lymphoma_burkitts(Daudi)4.7
Lymphoma_burkitts(Raji)5.1
MedullaOblongata3.4
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.4
Pancreas2.95
PancreaticIslet3.95
ParietalLobe3.85
Pituitary4.3
Placenta3.85
Pons3.6
PrefrontalCortex4.6
Prostate4.35
Salivarygland2.95
SkeletalMuscle4.35
Skin2.9
SmoothMuscle4.15
Spinalcord3.9
SubthalamicNucleus3.35
SuperiorCervicalGanglion4.3
TemporalLobe3.35
Testis3.2
TestisGermCell3.1
TestisIntersitial3.1
TestisLeydigCell3.65
TestisSeminiferousTubule3.15
Thalamus3.7
Thymus2.9
Thyroid4.65
Tongue3.6
Tonsil3.6
Trachea3.1
TrigeminalGanglion3.75
Uterus3.05
UterusCorpus3.25
WholeBlood4
Wholebrain3.15
colon3.7
pineal_day4.62
pineal_night4.52
retina4.45
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_946_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.6 ± 0.96
Basal Forebrain2.47 ± 0.59
Basal Part of Pons2.27 ± 0.63
Cerebellar Cortex3 ± 0.45
Cerebellar Nuclei2.87 ± 0.89
Claustrum2.95 ± 0.61
Epithalamus3.38 ± 0.53
Frontal Lobe2.27 ± 0.78
Globus Pallidus2.36 ± 0.62
Hypothalamus2.04 ± 0.62
Insula2 ± 0.43
Limbic Lobe2.33 ± 0.72
Mesencephalon2.64 ± 0.78
Myelencephalon2.43 ± 0.84
Occipital Lobe2.82 ± 0.71
Parietal Lobe2.31 ± 0.73
Pontine Tegmentum2.37 ± 0.7
Striatum2.39 ± 0.83
Subthalamus2.3 ± 0.85
Temporal Lobe2.21 ± 0.81
Thalamus2.26 ± 0.72
White Matter3.94 ± 0.84
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1r12bCBCerebellum3.71
3.4
Ppp1r12bCTXCerebral cortex8.15
2.64
Ppp1r12bHIPHippocampal region6.12
3.82
Ppp1r12bHPFHippocampal formation6.72
3.28
Ppp1r12bHYHypothalamus0.73
0.41
Ppp1r12bLSXLateral septal complex0.87
0.7
Ppp1r12bMBMidbrain1.24
0.67
Ppp1r12bMYMedulla4.08
2.26
Ppp1r12bOLFOlfactory bulb20.44
13.29
Ppp1r12bPPons3.17
1.36
Ppp1r12bPALPallidum0.92
0.46
Ppp1r12bRHPRetrohippocampal region7.96
2.61
Ppp1r12bsAMYStriatum-like amygdalar nuclei1.55
0.57
Ppp1r12bSTRStriatum1.06
0.39
Ppp1r12bSTRdStriatum dorsal region0.97
0.38
Ppp1r12bSTRvStriatum ventral region1.28
0.35
Ppp1r12bTHThalamus1.39
0.5
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MYPT2_HUMAN_189 10 189 198 KEEEQQMLQD PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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