AutismKB 2.0

Annotation Detail for NAGLU


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NAGLU ( MPS-IIIB,MPS3B,NAG,UFHSD )
Gene Full Name: N-acetylglucosaminidase, alpha
Band: 17q21.2
Quick LinksEntrez ID:4669; OMIM: 609701; Uniprot ID:ANAG_HUMAN; ENSEMBL ID: ENSG00000108784; HGNC ID: 7632
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult48 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma11 / 82823132
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor9 / 26384534
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal72 / 336030721
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer10 / 10268097
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow1 / 4880120
brain11 / 11009899
cervix1 / 4817120
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye12 / 21105456
heart0 / 896260 
intestine5 / 23447221
kidney16 / 21177775
larynx0 / 241450 
liver3 / 20774314
lung28 / 33697483
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate16 / 18934584
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach9 / 9661993
testis2 / 3304426
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215880_at
Cell line Expression level Expression bar
721_B_lymphoblasts11
Adipocyte9.4
AdrenalCortex11.55
Adrenalgland8.05
Amygdala9.8
Appendix10.35
AtrioventricularNode12
BDCA4+_DentriticCells10.2
Bonemarrow11
BronchialEpithelialCells9.45
CD105+_Endothelial9.65
CD14+_Monocytes9.95
CD19+_BCells(neg._sel.)10.4
CD33+_Myeloid11.1
CD34+10.1
CD4+_Tcells10.6
CD56+_NKCells9.65
CD71+_EarlyErythroid9.15
CD8+_Tcells9.35
CardiacMyocytes14.65
Caudatenucleus8.45
Cerebellum7.8
CerebellumPeduncles11.55
CiliaryGanglion7.8
CingulateCortex9.65
Colorectaladenocarcinoma11.9
DorsalRootGanglion8.6
FetalThyroid9
Fetalbrain9.65
Fetalliver8.25
Fetallung7.7
GlobusPallidus7.25
Heart14.65
Hypothalamus9.45
Kidney10.9
Leukemia_chronicMyelogenousK-5628.95
Leukemia_promyelocytic-HL-608.5
Leukemialymphoblastic(MOLT-4)7.6
Liver15.9
Lung10.5
Lymphnode7.75
Lymphoma_burkitts(Daudi)12.9
Lymphoma_burkitts(Raji)16.4
MedullaOblongata8.2
OccipitalLobe7.9
OlfactoryBulb7.2
Ovary7.15
Pancreas9.6
PancreaticIslet14.55
ParietalLobe10.7
Pituitary10.55
Placenta9.85
Pons9.35
PrefrontalCortex10.45
Prostate12
Salivarygland7.9
SkeletalMuscle12.8
Skin8.2
SmoothMuscle11
Spinalcord9.95
SubthalamicNucleus9.3
SuperiorCervicalGanglion11.9
TemporalLobe8.75
Testis8.25
TestisGermCell8.2
TestisIntersitial9.05
TestisLeydigCell9.9
TestisSeminiferousTubule8.2
Thalamus9.9
Thymus7.25
Thyroid12.1
Tongue9.6
Tonsil9.45
Trachea8.05
TrigeminalGanglion9.6
Uterus7.55
UterusCorpus9.4
WholeBlood9.45
Wholebrain7.8
colon8.75
pineal_day11.22
pineal_night11.34
retina11.65
small_intestine8.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P26945
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.31 ± 0.28
Basal Forebrain6.8 ± 0.29
Basal Part of Pons6.59 ± 0.26
Cerebellar Cortex6.35 ± 0.19
Cerebellar Nuclei7.16 ± 0.32
Claustrum6.28 ± 0.43
Epithalamus7.08 ± 0.27
Frontal Lobe6.68 ± 0.41
Globus Pallidus7.65 ± 0.27
Hypothalamus6.99 ± 0.31
Insula6.46 ± 0.37
Limbic Lobe6.35 ± 0.5
Mesencephalon6.81 ± 0.39
Myelencephalon6.75 ± 0.27
Occipital Lobe6.44 ± 0.41
Parietal Lobe6.48 ± 0.41
Pontine Tegmentum6.67 ± 0.39
Striatum6.98 ± 0.35
Subthalamus6.97 ± 0.07
Temporal Lobe6.55 ± 0.33
Thalamus6.85 ± 0.37
White Matter8.26 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NagluCBCerebellum7.7
9.03
NagluCTXCerebral cortex0.96
1.17
NagluHIPHippocampal region0.99
1.36
NagluHPFHippocampal formation0.76
0.87
NagluHYHypothalamus1.9
1.21
NagluLSXLateral septal complex2.02
3.26
NagluMBMidbrain1.95
3.48
NagluMYMedulla2.35
2.4
NagluOLFOlfactory bulb6.38
5.68
NagluPPons1.76
1.53
NagluPALPallidum3.76
4.48
NagluRHPRetrohippocampal region0.51
0.39
NaglusAMYStriatum-like amygdalar nuclei2.42
2.26
NagluSTRStriatum3.35
4.51
NagluSTRdStriatum dorsal region3.51
5.65
NagluSTRvStriatum ventral region4.13
3.67
NagluTHThalamus2.67
2.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ANAG_HUMAN_377 16 377 392 LLVLDLFAESQPVYTR PRIDE
ANAG_HUMAN_464 17 464 480 KDPVPDLAAWVTSFAAR PRIDE
ANAG_HUMAN_481 14 481 494 RYGVSHPDAGAAWR PRIDE
ANAG_HUMAN_593 22 593 614 AGGVLAYELLPALDEVLASDSR PRIDE
ANAG_HUMAN_615 11 615 625 FLLGSWLEQAR PRIDE
ANAG_HUMAN_676 23 676 698 LFLEALVDSVAQGIPFQQHQFDK PRIDE
PAp00091824 22 594 615 AGGVLAYELLPALDEVLASDSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved