AutismKB 2.0

Annotation Detail for ATF4


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Basic Information Top
Gene Symbol:ATF4 ( CREB-2,CREB2,TAXREB67,TXREB )
Gene Full Name: activating transcription factor 4 (tax-responsive enhancer element B67)
Band: 22q13.1
Quick LinksEntrez ID:468; OMIM: 604064; Uniprot ID:ATF4_HUMAN; ENSEMBL ID: ENSG00000128272; HGNC ID: 786
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body66 / 70761932
blastocyst50 / 62319802
fetus138 / 564012244
neonate5 / 31097160
infant29 / 236201227
juvenile49 / 55556881
adult888 / 1939121457
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor55 / 94178584
cervical tumor50 / 343661454
chondrosarcoma24 / 82823289
colorectal tumor72 / 114246630
esophageal tumor46 / 172902660
gastrointestinal tumor121 / 1193691013
germ cell tumor109 / 263845413
glioma32 / 106883299
head and neck tumor42 / 136302308
kidney tumor25 / 68959362
leukemia71 / 95842740
liver tumor86 / 96359892
lung tumor112 / 1031271086
lymphoma106 / 717551477
non-neoplasia25 / 97250257
normal1027 / 3360307305
ovarian tumor31 / 76682404
pancreatic tumor39 / 104616372
primitive neuroectodermal tumor of the CNS90 / 125680716
prostate cancer69 / 102680671
retinoblastoma31 / 46356668
skin tumor50 / 124949400
soft tissue/muscle tissue tumor51 / 125191407
uterine tumor58 / 90257642
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue9 / 13106686
adrenal gland11 / 33197331
ascites53 / 400151324
bladder6 / 29757201
blood86 / 123478696
bone35 / 71655488
bone marrow10 / 48801204
brain244 / 1100989221
cervix60 / 481711245
connective tissue28 / 149255187
ear4 / 16212246
embryonic tissue184 / 215722852
esophagus46 / 202092276
eye97 / 211054459
heart13 / 89626145
intestine120 / 234472511
kidney83 / 211777391
larynx46 / 241451905
liver149 / 207743717
lung178 / 336974528
lymph74 / 442701671
lymph node37 / 91610403
mammary gland70 / 153271456
mouth7 / 67052104
muscle74 / 107715686
nerve10 / 15768634
ovary34 / 102051333
pancreas79 / 214812367
parathyroid5 / 20539243
pharynx10 / 41328241
pituitary gland6 / 16585361
placenta155 / 280825551
prostate95 / 189345501
salivary gland7 / 20155347
skin68 / 210574322
spleen10 / 53952185
stomach55 / 96619569
testis42 / 330442127
thymus11 / 81131135
thyroid11 / 47473231
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord2 / 13680146
uterus107 / 232878459
vascular31 / 51780598
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200779_at
Cell line Expression level Expression bar
721_B_lymphoblasts1933.65
Adipocyte1063.5
AdrenalCortex1124.7
Adrenalgland688.35
Amygdala370.2
Appendix965.6
AtrioventricularNode383.95
BDCA4+_DentriticCells1551.8
Bonemarrow553.8
BronchialEpithelialCells1753.05
CD105+_Endothelial1549.2
CD14+_Monocytes1170.1
CD19+_BCells(neg._sel.)1680.5
CD33+_Myeloid2037.4
CD34+1409.15
CD4+_Tcells1107.25
CD56+_NKCells1216.8
CD71+_EarlyErythroid1175.6
CD8+_Tcells997.8
CardiacMyocytes1520.05
Caudatenucleus309.3
Cerebellum609.85
CerebellumPeduncles893.05
CiliaryGanglion496.75
CingulateCortex828.75
Colorectaladenocarcinoma1299.6
DorsalRootGanglion392.85
FetalThyroid907
Fetalbrain991.85
Fetalliver534.25
Fetallung1084.5
GlobusPallidus341.2
Heart280.95
Hypothalamus1001.35
Kidney274.15
Leukemia_chronicMyelogenousK-5621342.35
Leukemia_promyelocytic-HL-601235.95
Leukemialymphoblastic(MOLT-4)1706.2
Liver758.65
Lung1542.25
Lymphnode889.6
Lymphoma_burkitts(Daudi)3022.55
Lymphoma_burkitts(Raji)2618.4
MedullaOblongata673.95
OccipitalLobe476.9
OlfactoryBulb1006.4
Ovary517.9
Pancreas1188.6
PancreaticIslet1385.9
ParietalLobe541.25
Pituitary739.45
Placenta1538
Pons481.8
PrefrontalCortex764.05
Prostate1403.15
Salivarygland1146.55
SkeletalMuscle1670.15
Skin649.15
SmoothMuscle1867.55
Spinalcord825.75
SubthalamicNucleus589.15
SuperiorCervicalGanglion224.65
TemporalLobe615.95
Testis397
TestisGermCell934.8
TestisIntersitial592.1
TestisLeydigCell450
TestisSeminiferousTubule546.15
Thalamus746.75
Thymus737
Thyroid839.45
Tongue667.45
Tonsil760.9
Trachea614.35
TrigeminalGanglion564.2
Uterus983
UterusCorpus1039.85
WholeBlood578.95
Wholebrain856.65
colon826.1
pineal_day749.94
pineal_night673.12
retina934.3
small_intestine705.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P307065
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.29 ± 0.3
Basal Forebrain6.28 ± 0.38
Basal Part of Pons6.76 ± 0.24
Cerebellar Cortex6.68 ± 0.34
Cerebellar Nuclei6.6 ± 0.26
Claustrum6.45 ± 0.4
Epithalamus6.21 ± 0.44
Frontal Lobe6.64 ± 0.37
Globus Pallidus6.35 ± 0.16
Hypothalamus6.2 ± 0.76
Insula6.41 ± 0.36
Limbic Lobe6.44 ± 0.43
Mesencephalon6.36 ± 0.44
Myelencephalon6.36 ± 0.44
Occipital Lobe6.14 ± 0.41
Parietal Lobe6.47 ± 0.31
Pontine Tegmentum6.36 ± 0.35
Striatum5.78 ± 0.26
Subthalamus6.38 ± 0.26
Temporal Lobe6.43 ± 0.33
Thalamus6.51 ± 0.31
White Matter6.95 ± 0.36
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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