AutismKB 2.0

Annotation Detail for NDN


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Basic Information Top
Gene Symbol:NDN ( HsT16328,PWCR )
Gene Full Name: necdin homolog (mouse)
Band: 15q11.2
Quick LinksEntrez ID:4692; OMIM: 602117; Uniprot ID:NECD_HUMAN; ENSEMBL ID: ENSG00000182636; HGNC ID: 7675
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst7 / 62319112
fetus49 / 56401286
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult100 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor19 / 26384572
glioma4 / 10688337
head and neck tumor8 / 13630258
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal199 / 336030759
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain73 / 110098966
cervix1 / 4817120
connective tissue8 / 14925553
ear5 / 16212308
embryonic tissue24 / 215722111
esophagus0 / 202090 
eye11 / 21105452
heart4 / 8962644
intestine3 / 23447212
kidney7 / 21177733
larynx0 / 241450 
liver0 / 2077430 
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta46 / 280825163
prostate3 / 18934515
salivary gland6 / 20155297
skin9 / 21057442
spleen0 / 539520 
stomach0 / 966190 
testis13 / 33044239
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209550_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte91.6
AdrenalCortex17.9
Adrenalgland51.7
Amygdala148.8
Appendix17.3
AtrioventricularNode5.75
BDCA4+_DentriticCells7.05
Bonemarrow7.65
BronchialEpithelialCells8.8
CD105+_Endothelial7.75
CD14+_Monocytes6.4
CD19+_BCells(neg._sel.)5.9
CD33+_Myeloid8.9
CD34+13.15
CD4+_Tcells5.15
CD56+_NKCells6.5
CD71+_EarlyErythroid6.9
CD8+_Tcells4
CardiacMyocytes16.25
Caudatenucleus30.85
Cerebellum7.3
CerebellumPeduncles9.15
CiliaryGanglion6.15
CingulateCortex22.3
Colorectaladenocarcinoma3.8
DorsalRootGanglion6.25
FetalThyroid17.75
Fetalbrain88.9
Fetalliver13.5
Fetallung41.95
GlobusPallidus7.75
Heart31.3
Hypothalamus148.3
Kidney6.5
Leukemia_chronicMyelogenousK-5626.55
Leukemia_promyelocytic-HL-606.4
Leukemialymphoblastic(MOLT-4)13.4
Liver8.1
Lung91.7
Lymphnode6.9
Lymphoma_burkitts(Daudi)9.5
Lymphoma_burkitts(Raji)7.9
MedullaOblongata21.7
OccipitalLobe31.15
OlfactoryBulb10.8
Ovary9.6
Pancreas4.7
PancreaticIslet12.2
ParietalLobe14.15
Pituitary160.8
Placenta56.05
Pons21.95
PrefrontalCortex24.2
Prostate20.9
Salivarygland6.25
SkeletalMuscle9.65
Skin6.65
SmoothMuscle52.1
Spinalcord25.25
SubthalamicNucleus19.85
SuperiorCervicalGanglion10.7
TemporalLobe16.7
Testis41.15
TestisGermCell29.05
TestisIntersitial7
TestisLeydigCell9
TestisSeminiferousTubule7.9
Thalamus32.5
Thymus10.05
Thyroid37.45
Tongue9.25
Tonsil7.05
Trachea7.5
TrigeminalGanglion8.65
Uterus104.05
UterusCorpus62.35
WholeBlood6.2
Wholebrain251.7
colon10.45
pineal_day129.92
pineal_night92
retina153.475
small_intestine10.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9615_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.91 ± 0.45
Basal Forebrain5.22 ± 0.64
Basal Part of Pons4.84 ± 0.56
Cerebellar Cortex4.06 ± 0.69
Cerebellar Nuclei3.6 ± 0.61
Claustrum3.77 ± 0.77
Epithalamus5.01 ± 0.45
Frontal Lobe4.88 ± 0.67
Globus Pallidus4.22 ± 0.77
Hypothalamus5.51 ± 0.73
Insula5.02 ± 0.34
Limbic Lobe4.92 ± 0.53
Mesencephalon4.67 ± 0.72
Myelencephalon4.68 ± 0.71
Occipital Lobe4.22 ± 0.59
Parietal Lobe4.48 ± 0.6
Pontine Tegmentum4.55 ± 0.79
Striatum4.62 ± 0.84
Subthalamus4.19 ± 0.32
Temporal Lobe5 ± 0.61
Thalamus4.45 ± 0.53
White Matter4.32 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NdnCBCerebellum100
100
NdnCTXCerebral cortex100
100
NdnHIPHippocampal region100
100
NdnHPFHippocampal formation100
100
NdnHYHypothalamus100
100
NdnLSXLateral septal complex100
100
NdnMBMidbrain100
100
NdnMYMedulla100
100
NdnOLFOlfactory bulb100
100
NdnPPons100
100
NdnPALPallidum100
100
NdnRHPRetrohippocampal region100
100
NdnsAMYStriatum-like amygdalar nuclei100
100
NdnSTRStriatum100
100
NdnSTRdStriatum dorsal region67.05
63.74
NdnSTRvStriatum ventral region100
100
NdnTHThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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