AutismKB 2.0

Annotation Detail for ACLY


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Basic Information Top
Gene Symbol:ACLY ( ACL,ATPCL,CLATP )
Gene Full Name: ATP citrate lyase
Band: 17q21.2
Quick LinksEntrez ID:47; OMIM: 108728; Uniprot ID:ACLY_HUMAN; ENSEMBL ID: ENSG00000131473; HGNC ID: 115
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst21 / 62319336
fetus74 / 564012131
neonate2 / 3109764
infant1 / 2362042
juvenile10 / 55556179
adult254 / 1939121130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor17 / 94178180
cervical tumor9 / 34366261
chondrosarcoma9 / 82823108
colorectal tumor12 / 114246105
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor66 / 263845250
glioma17 / 106883159
head and neck tumor24 / 136302176
kidney tumor7 / 68959101
leukemia12 / 95842125
liver tumor17 / 96359176
lung tumor10 / 10312796
lymphoma18 / 71755250
non-neoplasia2 / 9725020
normal365 / 3360307108
ovarian tumor2 / 7668226
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS24 / 125680190
prostate cancer54 / 102680525
retinoblastoma37 / 46356798
skin tumor33 / 124949264
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites3 / 4001574
bladder6 / 29757201
blood5 / 12347840
bone11 / 71655153
bone marrow5 / 48801102
brain188 / 1100989170
cervix13 / 48171269
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue48 / 215722222
esophagus2 / 2020998
eye42 / 211054199
heart6 / 8962666
intestine20 / 23447285
kidney17 / 21177780
larynx2 / 2414582
liver21 / 207743101
lung33 / 33697497
lymph11 / 44270248
lymph node13 / 91610141
mammary gland20 / 153271130
mouth18 / 67052268
muscle6 / 10771555
nerve4 / 15768253
ovary5 / 10205148
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta28 / 28082599
prostate67 / 189345353
salivary gland0 / 201550 
skin43 / 210574204
spleen2 / 5395237
stomach3 / 9661931
testis65 / 330442196
thymus10 / 81131123
thyroid3 / 4747363
tonsil1 / 1699958
trachea15 / 52413286
umbilical cord4 / 13680292
uterus23 / 23287898
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210337_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts741.9
Adipocyte3172.25
AdrenalCortex24.1
Adrenalgland36.35
Amygdala29.65
Appendix24.15
AtrioventricularNode17.2
BDCA4+_DentriticCells224.6
Bonemarrow31.8
BronchialEpithelialCells595.05
CD105+_Endothelial69.65
CD14+_Monocytes160.05
CD19+_BCells(neg._sel.)55.15
CD33+_Myeloid102.8
CD34+167.2
CD4+_Tcells89
CD56+_NKCells263.75
CD71+_EarlyErythroid79.65
CD8+_Tcells121.25
CardiacMyocytes124.2
Caudatenucleus29.2
Cerebellum32.95
CerebellumPeduncles81.95
CiliaryGanglion33.8
CingulateCortex26.2
Colorectaladenocarcinoma269.15
DorsalRootGanglion22.85
FetalThyroid19.65
Fetalbrain98.15
Fetalliver40.9
Fetallung35.8
GlobusPallidus30.35
Heart27.8
Hypothalamus84.4
Kidney50.1
Leukemia_chronicMyelogenousK-562178.7
Leukemia_promyelocytic-HL-60180.8
Leukemialymphoblastic(MOLT-4)382.25
Liver26.35
Lung24.8
Lymphnode23.7
Lymphoma_burkitts(Daudi)174.45
Lymphoma_burkitts(Raji)97.35
MedullaOblongata20.5
OccipitalLobe47.15
OlfactoryBulb23.6
Ovary14.8
Pancreas26.7
PancreaticIslet160.15
ParietalLobe32.4
Pituitary35.1
Placenta114.95
Pons23.25
PrefrontalCortex30.35
Prostate86.85
Salivarygland22.15
SkeletalMuscle27.6
Skin16.55
SmoothMuscle485.65
Spinalcord25.3
SubthalamicNucleus21.3
SuperiorCervicalGanglion23.4
TemporalLobe22.75
Testis37.9
TestisGermCell38.15
TestisIntersitial57.2
TestisLeydigCell45.35
TestisSeminiferousTubule23.65
Thalamus40.15
Thymus63.9
Thyroid18.85
Tongue21.45
Tonsil54.5
Trachea29.5
TrigeminalGanglion19.9
Uterus11.55
UterusCorpus45.05
WholeBlood41.5
Wholebrain32.4
colon47.95
pineal_day1567.92
pineal_night1385.98
retina41.125
small_intestine57.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9014_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.75 ± 0.35
Basal Forebrain7.82 ± 0.63
Basal Part of Pons7.19 ± 0.14
Cerebellar Cortex6.71 ± 0.25
Cerebellar Nuclei7.47 ± 0.44
Claustrum7.32 ± 0.56
Epithalamus6.91 ± 0.37
Frontal Lobe7.05 ± 0.4
Globus Pallidus7.5 ± 0.54
Hypothalamus7.6 ± 0.31
Insula6.92 ± 0.39
Limbic Lobe6.89 ± 0.38
Mesencephalon7.13 ± 0.55
Myelencephalon7.07 ± 0.45
Occipital Lobe7.24 ± 0.48
Parietal Lobe7.09 ± 0.44
Pontine Tegmentum7.25 ± 0.56
Striatum7.3 ± 0.56
Subthalamus7.54 ± 0.17
Temporal Lobe7.07 ± 0.4
Thalamus7.27 ± 0.33
White Matter7.28 ± 0.7
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ACLY_HUMAN_0 0 0 0 FICTTSAIQNR PRIDE
ACLY_HUMAN_0 0 0 0 LLQDHPWLLSQNLVVKPDQLIK PRIDE
ACLY_HUMAN_0 0 0 0 TIAIIAEGIPEALTR PRIDE
ACLY_HUMAN_1066 12 1066 1077 SMGFIGHYLDQK PRIDE
ACLY_HUMAN_1066 13 1066 1078 SMGFIGHYLDQKR PRIDE
ACLY_HUMAN_17 11 17 27 FICTTSAIQNR PRIDE
ACLY_HUMAN_2 27 2 28 SAKAISEQTGKELLYKFICTTSAIQNR PRIDE
ACLY_HUMAN_209 11 209 219 DGVYVLDLAAK PRIDE
ACLY_HUMAN_232 12 232 243 WGDIEFPPPFGR PRIDE
ACLY_HUMAN_244 15 244 258 EAYPEEAYIADLDAK PRIDE
ACLY_HUMAN_322 8 322 329 TILSLMTR PRIDE
ACLY_HUMAN_362 16 362 377 DYQGPLKEHEVTIFVR PRIDE
ACLY_HUMAN_42 22 42 63 LLQDHPWLLSQNLVVKPDQLIK PRIDE
ACLY_HUMAN_470 14 470 483 AKPAMPQDSVPSPR PRIDE
ACLY_HUMAN_472 12 472 483 PAMPQDSVPSPR PRIDE
ACLY_HUMAN_484 12 484 495 SLQGKSTTLFSR PRIDE
ACLY_HUMAN_561 15 561 575 KHPEVDVLINFASLR PRIDE
ACLY_HUMAN_592 15 592 606 TIAIIAEGIPEALTR PRIDE
ACLY_HUMAN_593 15 593 607 TIAIIAEGIPEALTR PRIDE
ACLY_HUMAN_635 15 635 649 IGNTGGMLDNILASK PRIDE
ACLY_HUMAN_636 15 636 650 IGNTGGMLDNILASK PRIDE
ACLY_HUMAN_650 12 650 661 LYRPGSVAYVSR PRIDE
ACLY_HUMAN_654 9 654 662 PGSVAYVSR PRIDE
ACLY_HUMAN_662 14 662 675 SGGMSNELNNIISR PRIDE
ACLY_HUMAN_663 14 663 676 SGGMSNELNNIISR PRIDE
ACLY_HUMAN_676 27 676 702 TTDGVYEGVAIGGDRYPGSTFMDHVLR PRIDE
ACLY_HUMAN_68 14 68 81 LGLVGVNLTLDGVK PRIDE
ACLY_HUMAN_692 12 692 703 YPGSTFMDHVLR PRIDE
ACLY_HUMAN_767 22 767 788 QASETAVAKNQALKEAGVFVPR PRIDE
ACLY_HUMAN_915 19 915 933 AGKDLVSSLTSGLLTIGDR PRIDE
ACLY_HUMAN_915 29 915 943 AGKDLVSSLTSGLLTIGDRFGGALDAAAK PRIDE
ACLY_HUMAN_918 16 918 933 DLVSSLTSGLLTIGDR PRIDE
ACLY_HUMAN_918 26 918 943 DLVSSLTSGLLTIGDRFGGALDAAAK PRIDE
ACLY_HUMAN_948 14 948 961 AFDSGIIPMEFVNK PRIDE
ACLY_HUMAN_949 14 949 962 AFDSGIIPMEFVNK PRIDE
ACLY_HUMAN_969 8 969 976 LIMGIGHR PRIDE
ACLY_HUMAN_979 8 979 986 SINNPDMR PRIDE
ACLY_HUMAN_995 17 995 1011 QHFPATPLLDYALEVEK PRIDE
PAp00000792 14 508 521 AVQGMLDFDYVCSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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