AutismKB 2.0

Annotation Detail for NEDD4


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Basic Information Top
Gene Symbol:NEDD4 ( KIAA0093,MGC176705,NEDD4-1,RPF1 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4
Band: 15q21.3
Quick LinksEntrez ID:4734; OMIM: 602278; Uniprot ID:NEDD4_HUMAN; ENSEMBL ID: ENSG00000069869; HGNC ID: 7727
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus14 / 56401224
neonate3 / 3109796
infant0 / 236200 
juvenile0 / 555560 
adult60 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor3 / 26384511
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor33 / 96359342
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal100 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder8 / 29757268
blood1 / 1234788
bone5 / 7165569
bone marrow1 / 4880120
brain8 / 11009897
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye4 / 21105418
heart2 / 8962622
intestine3 / 23447212
kidney7 / 21177733
larynx0 / 241450 
liver39 / 207743187
lung5 / 33697414
lymph1 / 4427022
lymph node1 / 9161010
mammary gland10 / 15327165
mouth2 / 6705229
muscle9 / 10771583
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta10 / 28082535
prostate0 / 1893450 
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach3 / 9661931
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213012_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.2
Adipocyte11.35
AdrenalCortex13
Adrenalgland9.85
Amygdala10.15
Appendix13.75
AtrioventricularNode12.05
BDCA4+_DentriticCells9.9
Bonemarrow11.6
BronchialEpithelialCells11.4
CD105+_Endothelial10.75
CD14+_Monocytes11.15
CD19+_BCells(neg._sel.)11.6
CD33+_Myeloid12.25
CD34+61.25
CD4+_Tcells11
CD56+_NKCells12.9
CD71+_EarlyErythroid10.55
CD8+_Tcells9.45
CardiacMyocytes17.5
Caudatenucleus9.9
Cerebellum9.15
CerebellumPeduncles15
CiliaryGanglion10.55
CingulateCortex11.6
Colorectaladenocarcinoma11.55
DorsalRootGanglion9.1
FetalThyroid11.15
Fetalbrain11.1
Fetalliver17.85
Fetallung9.45
GlobusPallidus10
Heart17.2
Hypothalamus11.7
Kidney9.7
Leukemia_chronicMyelogenousK-56219.55
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)10.85
Liver17.4
Lung10.35
Lymphnode8.8
Lymphoma_burkitts(Daudi)14.6
Lymphoma_burkitts(Raji)15.8
MedullaOblongata10.05
OccipitalLobe9.7
OlfactoryBulb8.95
Ovary7.75
Pancreas9.15
PancreaticIslet11.8
ParietalLobe13.3
Pituitary13.35
Placenta9.45
Pons10.8
PrefrontalCortex12.25
Prostate12.75
Salivarygland8.9
SkeletalMuscle20.75
Skin12.95
SmoothMuscle49.1
Spinalcord11.95
SubthalamicNucleus10.4
SuperiorCervicalGanglion18.55
TemporalLobe10.65
Testis9.1
TestisGermCell9.5
TestisIntersitial10.05
TestisLeydigCell11.3
TestisSeminiferousTubule9.75
Thalamus11.45
Thymus7.5
Thyroid13.5
Tongue14.05
Tonsil11.05
Trachea9.5
TrigeminalGanglion11.75
Uterus12.2
UterusCorpus13.45
WholeBlood11.15
Wholebrain8.35
colon10.25
pineal_day13.66
pineal_night13.54
retina11.45
small_intestine9.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P160883
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.8 ± 0.7
Basal Forebrain3.66 ± 0.21
Basal Part of Pons3.26 ± 0.41
Cerebellar Cortex3.32 ± 0.72
Cerebellar Nuclei3.86 ± 0.57
Claustrum3.52 ± 0.92
Epithalamus3.57 ± 0.39
Frontal Lobe3.49 ± 0.61
Globus Pallidus4.27 ± 0.46
Hypothalamus3.49 ± 0.7
Insula3.04 ± 0.8
Limbic Lobe3.67 ± 0.51
Mesencephalon3.61 ± 0.7
Myelencephalon3.58 ± 0.63
Occipital Lobe3.56 ± 0.66
Parietal Lobe3.39 ± 0.61
Pontine Tegmentum3.6 ± 0.47
Striatum4.17 ± 0.44
Subthalamus3.82 ± 0.08
Temporal Lobe3.45 ± 0.59
Thalamus3.53 ± 0.58
White Matter4.04 ± 0.15
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00028982 7 964 970 AHTCFNR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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