AutismKB 2.0

Annotation Detail for NEDD8


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Basic Information Top
Gene Symbol:NEDD8 ( FLJ43224,MGC104393,MGC125896,MGC125897,Nedd-8 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 8
Band: 14q12
Quick LinksEntrez ID:4738; OMIM: 603171; Uniprot ID:NEDD8_HUMAN; ENSEMBL ID: ENSG00000129559; HGNC ID: 7732
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst12 / 62319192
fetus54 / 56401295
neonate4 / 31097128
infant0 / 236200 
juvenile3 / 5555653
adult129 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor9 / 26384534
glioma9 / 10688384
head and neck tumor10 / 13630273
kidney tumor5 / 6895972
leukemia8 / 9584283
liver tumor9 / 9635993
lung tumor10 / 10312796
lymphoma4 / 7175555
non-neoplasia5 / 9725051
normal243 / 336030772
ovarian tumor4 / 7668252
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor14 / 124949112
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites2 / 4001549
bladder0 / 297570 
blood11 / 12347889
bone6 / 7165583
bone marrow1 / 4880120
brain47 / 110098942
cervix1 / 4817120
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue29 / 215722134
esophagus0 / 202090 
eye24 / 211054113
heart25 / 89626278
intestine15 / 23447263
kidney19 / 21177789
larynx1 / 2414541
liver10 / 20774348
lung40 / 336974118
lymph3 / 4427067
lymph node7 / 9161076
mammary gland9 / 15327158
mouth0 / 670520 
muscle6 / 10771555
nerve1 / 1576863
ovary7 / 10205168
pancreas25 / 214812116
parathyroid16 / 20539779
pharynx2 / 4132848
pituitary gland7 / 16585422
placenta7 / 28082524
prostate16 / 18934584
salivary gland7 / 20155347
skin32 / 210574151
spleen0 / 539520 
stomach4 / 9661941
testis7 / 33044221
thymus2 / 8113124
thyroid3 / 4747363
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord4 / 13680292
uterus13 / 23287855
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201840_at
Cell line Expression level Expression bar
721_B_lymphoblasts693.25
Adipocyte371.85
AdrenalCortex211.1
Adrenalgland163.4
Amygdala272.05
Appendix152.95
AtrioventricularNode87.1
BDCA4+_DentriticCells689.7
Bonemarrow193.8
BronchialEpithelialCells1041.25
CD105+_Endothelial583.2
CD14+_Monocytes602.95
CD19+_BCells(neg._sel.)557.95
CD33+_Myeloid610.55
CD34+628.35
CD4+_Tcells517.65
CD56+_NKCells629.9
CD71+_EarlyErythroid388.6
CD8+_Tcells441.25
CardiacMyocytes555.75
Caudatenucleus270.65
Cerebellum167.4
CerebellumPeduncles346.8
CiliaryGanglion95.95
CingulateCortex365.2
Colorectaladenocarcinoma127.35
DorsalRootGanglion128.1
FetalThyroid262.1
Fetalbrain253.9
Fetalliver137
Fetallung185.65
GlobusPallidus270.05
Heart122.9
Hypothalamus545.15
Kidney157.3
Leukemia_chronicMyelogenousK-562206.35
Leukemia_promyelocytic-HL-60342.85
Leukemialymphoblastic(MOLT-4)350.9
Liver103.55
Lung192.35
Lymphnode182.2
Lymphoma_burkitts(Daudi)393.6
Lymphoma_burkitts(Raji)210.9
MedullaOblongata305.75
OccipitalLobe367.7
OlfactoryBulb220.95
Ovary135.5
Pancreas117.4
PancreaticIslet274.65
ParietalLobe284.5
Pituitary365.35
Placenta329.45
Pons231.05
PrefrontalCortex555.4
Prostate168.4
Salivarygland133.05
SkeletalMuscle149.5
Skin90.1
SmoothMuscle852.7
Spinalcord259.35
SubthalamicNucleus404.55
SuperiorCervicalGanglion101.05
TemporalLobe397.75
Testis170.7
TestisGermCell178.6
TestisIntersitial133.25
TestisLeydigCell122.45
TestisSeminiferousTubule143.6
Thalamus546.45
Thymus305.2
Thyroid221.45
Tongue159
Tonsil270.7
Trachea139.7
TrigeminalGanglion130.15
Uterus130.75
UterusCorpus112.5
WholeBlood430.3
Wholebrain506.35
colon200.75
pineal_day474.82
pineal_night531.68
retina437.55
small_intestine222.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P159135
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.72 ± 0.41
Basal Forebrain9.72 ± 0.21
Basal Part of Pons10.52 ± 0.38
Cerebellar Cortex9.97 ± 0.38
Cerebellar Nuclei10.07 ± 0.32
Claustrum9.64 ± 0.59
Epithalamus9.78 ± 0.62
Frontal Lobe10.25 ± 0.42
Globus Pallidus9.68 ± 0.42
Hypothalamus10.12 ± 0.65
Insula10.3 ± 0.33
Limbic Lobe9.84 ± 0.59
Mesencephalon9.87 ± 0.46
Myelencephalon9.94 ± 0.53
Occipital Lobe9.34 ± 0.58
Parietal Lobe10.03 ± 0.46
Pontine Tegmentum9.94 ± 0.44
Striatum9.51 ± 0.44
Subthalamus10.46 ± 0.18
Temporal Lobe10.2 ± 0.43
Thalamus9.97 ± 0.29
White Matter9.31 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nedd8CBCerebellum19.12
65.5
Nedd8CTXCerebral cortex100
100
Nedd8HIPHippocampal region100
100
Nedd8HPFHippocampal formation100
100
Nedd8HYHypothalamus90.19
100
Nedd8LSXLateral septal complex100
100
Nedd8MBMidbrain54.15
72.3
Nedd8MYMedulla24.96
51.21
Nedd8OLFOlfactory bulb80.12
100
Nedd8PPons45.5
77.36
Nedd8PALPallidum100
100
Nedd8RHPRetrohippocampal region100
100
Nedd8sAMYStriatum-like amygdalar nuclei100
100
Nedd8STRStriatum100
100
Nedd8STRdStriatum dorsal region100
100
Nedd8STRvStriatum ventral region100
100
Nedd8THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NEDD8_HUMAN_0 0 0 0 EIEIDIEPTDKVER PRIDE
NEDD8_HUMAN_0 0 0 0 TLTGKEIEIDIEPTDKVER PRIDE
NEDD8_HUMAN_11 14 11 24 EIEIDIEPTDKVER PRIDE
NEDD8_HUMAN_34 9 34 42 EGIPPQQQR PRIDE
NEDD8_HUMAN_6 19 6 24 TLTGKEIEIDIEPTDKVER PRIDE
NEDD8_HUMAN_60 14 60 73 ILGGSVLHLVLALR PRIDE
PAp00062138 14 61 74 ILGGSVLHLVLALR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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