AutismKB 2.0

Annotation Detail for NEK2


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Basic Information Top
Gene Symbol:NEK2 ( HsPK21,NEK2A,NLK1 )
Gene Full Name: NIMA (never in mitosis gene a)-related kinase 2
Band: 1q32.3
Quick LinksEntrez ID:4751; OMIM: 604043; Uniprot ID:NEK2_HUMAN; ENSEMBL ID: ENSG00000117650; HGNC ID: 7745
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus21 / 56401237
neonate0 / 310970 
infant1 / 2362042
juvenile4 / 5555671
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma5 / 17475286
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor14 / 26384553
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia8 / 9584283
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal77 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder6 / 29757201
blood8 / 12347864
bone7 / 7165597
bone marrow4 / 4880181
brain23 / 110098920
cervix1 / 4817120
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine4 / 23447217
kidney4 / 21177718
larynx1 / 2414541
liver7 / 20774333
lung2 / 3369745
lymph0 / 442700 
lymph node1 / 9161010
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate7 / 18934536
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis40 / 330442121
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204641_at
Cell line Expression level Expression bar
721_B_lymphoblasts306.4
Adipocyte8.8
AdrenalCortex12.75
Adrenalgland8.3
Amygdala9.15
Appendix13.2
AtrioventricularNode12.9
BDCA4+_DentriticCells8.2
Bonemarrow16.15
BronchialEpithelialCells10.05
CD105+_Endothelial318.5
CD14+_Monocytes9.65
CD19+_BCells(neg._sel.)8.95
CD33+_Myeloid12.85
CD34+34.2
CD4+_Tcells8.85
CD56+_NKCells9.9
CD71+_EarlyErythroid234.6
CD8+_Tcells7.4
CardiacMyocytes23.6
Caudatenucleus8.15
Cerebellum7.5
CerebellumPeduncles11.4
CiliaryGanglion9.85
CingulateCortex9.75
Colorectaladenocarcinoma50
DorsalRootGanglion8.95
FetalThyroid9.15
Fetalbrain8.75
Fetalliver31.7
Fetallung7.7
GlobusPallidus7.55
Heart17.45
Hypothalamus9.5
Kidney8.9
Leukemia_chronicMyelogenousK-562110.45
Leukemia_promyelocytic-HL-6060.25
Leukemialymphoblastic(MOLT-4)55.4
Liver16.05
Lung9.75
Lymphnode7.15
Lymphoma_burkitts(Daudi)65.25
Lymphoma_burkitts(Raji)58.7
MedullaOblongata8.45
OccipitalLobe8.05
OlfactoryBulb6.9
Ovary7.55
Pancreas8.05
PancreaticIslet9.7
ParietalLobe10.45
Pituitary10.7
Placenta8.45
Pons9.2
PrefrontalCortex10.5
Prostate17.1
Salivarygland7.9
SkeletalMuscle15.05
Skin10.85
SmoothMuscle10.75
Spinalcord9.7
SubthalamicNucleus8.55
SuperiorCervicalGanglion17.15
TemporalLobe11.7
Testis387.1
TestisGermCell161.5
TestisIntersitial204.45
TestisLeydigCell134.25
TestisSeminiferousTubule160.7
Thalamus9.6
Thymus9.85
Thyroid10.85
Tongue11.85
Tonsil9.3
Trachea7.45
TrigeminalGanglion15.3
Uterus6.85
UterusCorpus9.55
WholeBlood9.9
Wholebrain7.35
colon11.5
pineal_day10.7
pineal_night10.38
retina10.675
small_intestine37.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P319613
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.95 ± 0.83
Basal Forebrain2.23 ± 0.23
Basal Part of Pons2.23 ± 0.4
Cerebellar Cortex2.25 ± 0.66
Cerebellar Nuclei2.64 ± 0.66
Claustrum3.05 ± 0.86
Epithalamus2.91 ± 1.06
Frontal Lobe2.72 ± 0.74
Globus Pallidus2.84 ± 0.36
Hypothalamus2.33 ± 0.66
Insula2.62 ± 0.72
Limbic Lobe2.73 ± 0.66
Mesencephalon2.67 ± 0.8
Myelencephalon2.63 ± 0.74
Occipital Lobe2.23 ± 0.75
Parietal Lobe2.56 ± 0.93
Pontine Tegmentum2.65 ± 0.82
Striatum2.33 ± 0.61
Subthalamus2.62 ± 0.7
Temporal Lobe2.67 ± 0.81
Thalamus2.34 ± 0.74
White Matter2.52 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nek2CBCerebellum11.47
19.2
Nek2CTXCerebral cortex0.39
0.43
Nek2HIPHippocampal region0.48
0.52
Nek2HPFHippocampal formation0.51
0.5
Nek2HYHypothalamus0.19
0.16
Nek2LSXLateral septal complex0.88
0.75
Nek2MBMidbrain0.58
0.99
Nek2MYMedulla0.74
1.15
Nek2OLFOlfactory bulb1.39
2.15
Nek2PPons1.07
1.7
Nek2PALPallidum0.17
0.11
Nek2RHPRetrohippocampal region0.58
0.43
Nek2sAMYStriatum-like amygdalar nuclei0.33
0.27
Nek2STRStriatum0.36
0.31
Nek2STRdStriatum dorsal region0.3
0.25
Nek2STRvStriatum ventral region0.4
0.34
Nek2THThalamus0.2
0.27
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NEK2_HUMAN_255 30 255 284 DYHRPSVEEILENPLIADLVADEQRRNLER PRIDE
NEK2_HUMAN_440 6 440 445 QILGMR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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