Annotation Detail for NEK3
Basic Information Top
| Gene Symbol: | NEK3 ( HSPK36,MGC29949 ) |
|---|---|
| Gene Full Name: | NIMA (never in mitosis gene a)-related kinase 3 |
| Band: | 13q14.3 |
| Quick Links | Entrez ID:4752; OMIM: 604044; Uniprot ID:NEK3_HUMAN; ENSEMBL ID: ENSG00000136098; HGNC ID: 7746 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.409989
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 17 / 564012 | 30 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 43 / 1939121 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 6 / 114246 | 52 |  |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 1 / 119369 | 8 |  |
| germ cell tumor | 9 / 263845 | 34 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 2 / 136302 | 14 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 5 / 96359 | 51 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 3 / 71755 | 41 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 63 / 3360307 | 18 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 12 / 1100989 | 10 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 2 / 149255 | 13 | |
| ear | 3 / 16212 | 185 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 9 / 211054 | 42 | |
| heart | 0 / 89626 | 0 | |
| intestine | 8 / 234472 | 34 | |
| kidney | 8 / 211777 | 37 | |
| larynx | 1 / 24145 | 41 | |
| liver | 6 / 207743 | 28 | |
| lung | 6 / 336974 | 17 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 2 / 91610 | 21 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 5 / 280825 | 17 | |
| prostate | 2 / 189345 | 10 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 1 / 210574 | 4 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 12 / 330442 | 36 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 4 / 232878 | 17 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 213116_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.25 | |
| Adipocyte | 5.8 | |
| AdrenalCortex | 6.1 | |
| Adrenalgland | 4.9 | |
| Amygdala | 6.15 | |
| Appendix | 5.85 | |
| AtrioventricularNode | 4.5 | |
| BDCA4+_DentriticCells | 24.6 | |
| Bonemarrow | 5.65 | |
| BronchialEpithelialCells | 5.85 | |
| CD105+_Endothelial | 5.1 | |
| CD14+_Monocytes | 6.35 | |
| CD19+_BCells(neg._sel.) | 7.1 | |
| CD33+_Myeloid | 16.15 | |
| CD34+ | 9.75 | |
| CD4+_Tcells | 6.5 | |
| CD56+_NKCells | 9.7 | |
| CD71+_EarlyErythroid | 5.1 | |
| CD8+_Tcells | 5.5 | |
| CardiacMyocytes | 7.6 | |
| Caudatenucleus | 5.3 | |
| Cerebellum | 4.65 | |
| CerebellumPeduncles | 6.6 | |
| CiliaryGanglion | 4.2 | |
| CingulateCortex | 6.2 | |
| Colorectaladenocarcinoma | 6.3 | |
| DorsalRootGanglion | 4.5 | |
| FetalThyroid | 5.6 | |
| Fetalbrain | 8.95 | |
| Fetalliver | 4.8 | |
| Fetallung | 6.7 | |
| GlobusPallidus | 4.35 | |
| Heart | 7.6 | |
| Hypothalamus | 14.85 | |
| Kidney | 4.6 | |
| Leukemia_chronicMyelogenousK-562 | 5.3 | |
| Leukemia_promyelocytic-HL-60 | 4.3 | |
| Leukemialymphoblastic(MOLT-4) | 4.15 | |
| Liver | 7.65 | |
| Lung | 5.8 | |
| Lymphnode | 5.85 | |
| Lymphoma_burkitts(Daudi) | 7.4 | |
| Lymphoma_burkitts(Raji) | 8.05 | |
| MedullaOblongata | 6.3 | |
| OccipitalLobe | 5.4 | |
| OlfactoryBulb | 6.45 | |
| Ovary | 3.85 | |
| Pancreas | 64.1 | |
| PancreaticIslet | 6.3 | |
| ParietalLobe | 6.5 | |
| Pituitary | 6.75 | |
| Placenta | 5.35 | |
| Pons | 6.2 | |
| PrefrontalCortex | 8 | |
| Prostate | 6.8 | |
| Salivarygland | 4.65 | |
| SkeletalMuscle | 6.9 | |
| Skin | 5.05 | |
| SmoothMuscle | 6.55 | |
| Spinalcord | 7.35 | |
| SubthalamicNucleus | 5.35 | |
| SuperiorCervicalGanglion | 6.7 | |
| TemporalLobe | 5.35 | |
| Testis | 5.15 | |
| TestisGermCell | 51.65 | |
| TestisIntersitial | 12.1 | |
| TestisLeydigCell | 13.35 | |
| TestisSeminiferousTubule | 18.5 | |
| Thalamus | 7.5 | |
| Thymus | 4.3 | |
| Thyroid | 7.3 | |
| Tongue | 5.7 | |
| Tonsil | 5.6 | |
| Trachea | 4.8 | |
| TrigeminalGanglion | 5.9 | |
| Uterus | 4.8 | |
| UterusCorpus | 5.3 | |
| WholeBlood | 6.25 | |
| Wholebrain | 5.05 | |
| colon | 13.2 | |
| pineal_day | 7.26 | |
| pineal_night | 7.18 | |
| retina | 9.675 | |
| small_intestine | 5.85 | |
- Probe name: A_23_P333705
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.59 ± 0.64 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.57 ± 0.4 | |
| Basal Part of Pons | 5.17 ± 0.73 | |
| Cerebellar Cortex | 4.78 ± 0.25 | |
| Cerebellar Nuclei | 5.56 ± 0.55 | |
| Claustrum | 4.64 ± 0.63 | |
| Epithalamus | 5.3 ± 0.46 | |
| Frontal Lobe | 5.12 ± 0.71 | |
| Globus Pallidus | 6.51 ± 0.3 | |
| Hypothalamus | 4.54 ± 0.54 | |
| Insula | 4.74 ± 0.42 | |
| Limbic Lobe | 4.84 ± 0.65 | |
| Mesencephalon | 5.21 ± 0.71 | |
| Myelencephalon | 5.11 ± 0.62 | |
| Occipital Lobe | 5 ± 0.63 | |
| Parietal Lobe | 4.95 ± 0.62 | |
| Pontine Tegmentum | 5.13 ± 0.58 | |
| Striatum | 5.65 ± 0.49 | |
| Subthalamus | 5.17 ± 0.59 | |
| Temporal Lobe | 4.93 ± 0.51 | |
| Thalamus | 5.49 ± 0.46 | |
| White Matter | 7.66 ± 0.36 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Nek3 | CB | Cerebellum | 0.31 | |
| 0.79 | | |||
| Nek3 | CTX | Cerebral cortex | 0.2 | |
| 0.22 | | |||
| Nek3 | HIP | Hippocampal region | 0.17 | |
| 0.38 | | |||
| Nek3 | HPF | Hippocampal formation | 0.27 | |
| 0.42 | | |||
| Nek3 | HY | Hypothalamus | 0 | |
| 0 | | |||
| Nek3 | LSX | Lateral septal complex | 0 | |
| 0 | | |||
| Nek3 | MB | Midbrain | 0.95 | |
| 1.76 | | |||
| Nek3 | MY | Medulla | 0.55 | |
| 1.11 | | |||
| Nek3 | OLF | Olfactory bulb | 0.82 | |
| 0.64 | | |||
| Nek3 | P | Pons | 0.65 | |
| 1.1 | | |||
| Nek3 | PAL | Pallidum | 0.12 | |
| 0.13 | | |||
| Nek3 | RHP | Retrohippocampal region | 0.43 | |
| 0.49 | | |||
| Nek3 | sAMY | Striatum-like amygdalar nuclei | 0.12 | |
| 0.06 | | |||
| Nek3 | STR | Striatum | 0.11 | |
| 0.11 | | |||
| Nek3 | STRd | Striatum dorsal region | 0.13 | |
| 0.15 | | |||
| Nek3 | STRv | Striatum ventral region | 0.05 | |
| 0.02 | | |||
| Nek3 | TH | Thalamus | 0.13 | |
| 0.29 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00496813 | 26 | 444 | 469 | GPLSEETEASDSVDGGHDSVILDPER | Peptide Atlas |