AutismKB 2.0

Annotation Detail for NEO1


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Basic Information Top
Gene Symbol:NEO1 ( DKFZp547A066,DKFZp547B146,IGDCC2,NGN )
Gene Full Name: neogenin 1
Band: 15q24.1
Quick LinksEntrez ID:4756; OMIM: 601907; Uniprot ID:NEO1_HUMAN; ENSEMBL ID: ENSG00000067141; HGNC ID: 7754
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst4 / 6231964
fetus42 / 56401274
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult131 / 193912167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor26 / 114246227
esophageal tumor2 / 17290115
gastrointestinal tumor5 / 11936941
germ cell tumor8 / 26384530
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor10 / 68959145
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal190 / 336030756
ovarian tumor15 / 76682195
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer10 / 10268097
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain52 / 110098947
cervix2 / 4817141
connective tissue3 / 14925520
ear4 / 16212246
embryonic tissue17 / 21572278
esophagus2 / 2020998
eye11 / 21105452
heart3 / 8962633
intestine41 / 234472174
kidney16 / 21177775
larynx2 / 2414582
liver0 / 2077430 
lung31 / 33697491
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth3 / 6705244
muscle1 / 1077159
nerve1 / 1576863
ovary17 / 102051166
pancreas17 / 21481279
parathyroid8 / 20539389
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta1 / 2808253
prostate25 / 189345132
salivary gland0 / 201550 
skin13 / 21057461
spleen0 / 539520 
stomach1 / 9661910
testis17 / 33044251
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204321_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.6
Adipocyte3.7
AdrenalCortex3.85
Adrenalgland3.15
Amygdala4.65
Appendix5.05
AtrioventricularNode2.85
BDCA4+_DentriticCells4.05
Bonemarrow3.65
BronchialEpithelialCells3.65
CD105+_Endothelial3.8
CD14+_Monocytes3.9
CD19+_BCells(neg._sel.)3.95
CD33+_Myeloid4.75
CD34+4.7
CD4+_Tcells4.15
CD56+_NKCells4.45
CD71+_EarlyErythroid3.5
CD8+_Tcells3.6
CardiacMyocytes4.65
Caudatenucleus3.5
Cerebellum5.55
CerebellumPeduncles4.2
CiliaryGanglion2.55
CingulateCortex3.75
Colorectaladenocarcinoma3.75
DorsalRootGanglion2.85
FetalThyroid5.5
Fetalbrain11.65
Fetalliver3.25
Fetallung5.4
GlobusPallidus2.7
Heart4.65
Hypothalamus4.55
Kidney3.05
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3
Liver4.9
Lung5.55
Lymphnode3.15
Lymphoma_burkitts(Daudi)4.75
Lymphoma_burkitts(Raji)5.2
MedullaOblongata5.2
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.45
Pancreas2.95
PancreaticIslet6.15
ParietalLobe3.95
Pituitary4.35
Placenta4
Pons4.25
PrefrontalCortex4.8
Prostate11.25
Salivarygland3
SkeletalMuscle4.15
Skin2.9
SmoothMuscle4.25
Spinalcord4.05
SubthalamicNucleus3.4
SuperiorCervicalGanglion6.95
TemporalLobe3.4
Testis7.35
TestisGermCell8.25
TestisIntersitial3.3
TestisLeydigCell3.95
TestisSeminiferousTubule3.3
Thalamus3.8
Thymus2.9
Thyroid4.8
Tongue3.6
Tonsil3.6
Trachea3.1
TrigeminalGanglion3.95
Uterus4.15
UterusCorpus3.3
WholeBlood4.05
Wholebrain5.8
colon15.75
pineal_day7.94
pineal_night11.34
retina7.85
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9569_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.12 ± 0.31
Basal Forebrain8.13 ± 0.24
Basal Part of Pons7.81 ± 0.28
Cerebellar Cortex7.93 ± 0.21
Cerebellar Nuclei8.21 ± 0.46
Claustrum8.17 ± 0.57
Epithalamus8.2 ± 0.23
Frontal Lobe8.04 ± 0.4
Globus Pallidus9.05 ± 0.23
Hypothalamus7.81 ± 0.24
Insula7.88 ± 0.26
Limbic Lobe8.23 ± 0.41
Mesencephalon8.2 ± 0.31
Myelencephalon8.17 ± 0.4
Occipital Lobe8.36 ± 0.42
Parietal Lobe8.21 ± 0.31
Pontine Tegmentum8.25 ± 0.36
Striatum8.37 ± 0.41
Subthalamus7.86 ± 0.22
Temporal Lobe7.98 ± 0.29
Thalamus8.33 ± 0.28
White Matter9.76 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Neo1CBCerebellum53.87
61.38
Neo1CTXCerebral cortex100
100
Neo1HIPHippocampal region88.58
100
Neo1HPFHippocampal formation92.21
100
Neo1HYHypothalamus76.4
67.07
Neo1LSXLateral septal complex70.29
53.39
Neo1MBMidbrain76.73
66.01
Neo1MYMedulla78.81
72.44
Neo1OLFOlfactory bulb100
100
Neo1PPons70.61
63.07
Neo1PALPallidum78.83
72.67
Neo1RHPRetrohippocampal region100
87.96
Neo1sAMYStriatum-like amygdalar nuclei100
85.37
Neo1STRStriatum76.99
58.57
Neo1STRdStriatum dorsal region68.45
50.71
Neo1STRvStriatum ventral region96.94
73.36
Neo1THThalamus100
85.85
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00134024 20 1408 1427 SRPPMPVVVPSAPEVQETTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018