AutismKB 2.0

Annotation Detail for NFATC4


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Basic Information Top
Gene Symbol:NFATC4 ( NF-ATc4,NFAT3 )
Gene Full Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Band: 14q12
Quick LinksEntrez ID:4776; OMIM: 602699; Uniprot ID:NFAC4_HUMAN; ENSEMBL ID: ENSG00000100968; HGNC ID: 7778
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus55 / 56401297
neonate11 / 31097353
infant0 / 236200 
juvenile4 / 5555671
adult128 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor26 / 26384598
glioma5 / 10688346
head and neck tumor17 / 136302124
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal267 / 336030779
ovarian tumor10 / 76682130
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor8 / 12494964
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone12 / 71655167
bone marrow0 / 488010 
brain95 / 110098986
cervix0 / 481710 
connective tissue16 / 149255107
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye10 / 21105447
heart13 / 89626145
intestine6 / 23447225
kidney11 / 21177751
larynx0 / 241450 
liver1 / 2077434
lung18 / 33697453
lymph0 / 442700 
lymph node1 / 9161010
mammary gland4 / 15327126
mouth11 / 67052164
muscle6 / 10771555
nerve1 / 1576863
ovary14 / 102051137
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta44 / 280825156
prostate2 / 18934510
salivary gland2 / 2015599
skin24 / 210574113
spleen1 / 5395218
stomach2 / 9661920
testis56 / 330442169
thymus5 / 8113161
thyroid4 / 4747384
tonsil0 / 169990 
trachea28 / 52413534
umbilical cord2 / 13680146
uterus76 / 232878326
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205897_at
Cell line Expression level Expression bar
721_B_lymphoblasts39.95
Adipocyte56.35
AdrenalCortex58.8
Adrenalgland85.55
Amygdala60.7
Appendix56.8
AtrioventricularNode42.6
BDCA4+_DentriticCells39.05
Bonemarrow63.35
BronchialEpithelialCells52.6
CD105+_Endothelial25.25
CD14+_Monocytes36.95
CD19+_BCells(neg._sel.)35.95
CD33+_Myeloid32.9
CD34+44.3
CD4+_Tcells45.35
CD56+_NKCells33.1
CD71+_EarlyErythroid53.2
CD8+_Tcells34.9
CardiacMyocytes67.15
Caudatenucleus54.8
Cerebellum57.05
CerebellumPeduncles84.6
CiliaryGanglion32.2
CingulateCortex68.2
Colorectaladenocarcinoma56.85
DorsalRootGanglion42.95
FetalThyroid55.05
Fetalbrain63.3
Fetalliver62.5
Fetallung44.85
GlobusPallidus42.85
Heart95.1
Hypothalamus62.45
Kidney51.85
Leukemia_chronicMyelogenousK-56251.3
Leukemia_promyelocytic-HL-6051.4
Leukemialymphoblastic(MOLT-4)45.95
Liver74.5
Lung62.6
Lymphnode53.25
Lymphoma_burkitts(Daudi)72.2
Lymphoma_burkitts(Raji)116.25
MedullaOblongata63.25
OccipitalLobe51.2
OlfactoryBulb44.9
Ovary46.7
Pancreas46.65
PancreaticIslet60.65
ParietalLobe70.15
Pituitary80.4
Placenta59.35
Pons93.6
PrefrontalCortex70.9
Prostate60.85
Salivarygland45.05
SkeletalMuscle65.35
Skin43.25
SmoothMuscle64.75
Spinalcord60.75
SubthalamicNucleus51.45
SuperiorCervicalGanglion65.95
TemporalLobe75.75
Testis70.6
TestisGermCell44.55
TestisIntersitial51.05
TestisLeydigCell56.35
TestisSeminiferousTubule65.9
Thalamus57.65
Thymus45.4
Thyroid72.2
Tongue55.2
Tonsil55.1
Trachea47.6
TrigeminalGanglion55.8
Uterus47.05
UterusCorpus54.85
WholeBlood58.95
Wholebrain49
colon57.25
pineal_day52.44
pineal_night44.6
retina70
small_intestine55.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P140394
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.48 ± 0.79
Basal Forebrain7.41 ± 0.49
Basal Part of Pons7.06 ± 0.7
Cerebellar Cortex6.8 ± 0.56
Cerebellar Nuclei7.32 ± 0.43
Claustrum7.81 ± 0.83
Epithalamus6.71 ± 0.44
Frontal Lobe7.16 ± 0.65
Globus Pallidus7.79 ± 0.4
Hypothalamus7.24 ± 0.54
Insula7 ± 0.42
Limbic Lobe7.34 ± 0.66
Mesencephalon7.31 ± 0.63
Myelencephalon7.26 ± 0.6
Occipital Lobe7.1 ± 0.74
Parietal Lobe7.06 ± 0.52
Pontine Tegmentum7.05 ± 0.53
Striatum7.4 ± 0.61
Subthalamus7.3 ± 0.26
Temporal Lobe7.06 ± 0.63
Thalamus7.24 ± 0.56
White Matter7.4 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nfatc4CBCerebellum37.64
55.4
Nfatc4CTXCerebral cortex22.89
18.36
Nfatc4HIPHippocampal region7.22
6.55
Nfatc4HPFHippocampal formation17.24
14.7
Nfatc4HYHypothalamus0.61
0.65
Nfatc4LSXLateral septal complex0.37
0.39
Nfatc4MBMidbrain2.51
2.96
Nfatc4MYMedulla9.77
9.04
Nfatc4OLFOlfactory bulb21.85
17.43
Nfatc4PPons3.39
3.4
Nfatc4PALPallidum0.78
0.6
Nfatc4RHPRetrohippocampal region34.31
26.22
Nfatc4sAMYStriatum-like amygdalar nuclei7.44
5.53
Nfatc4STRStriatum5.94
4.15
Nfatc4STRdStriatum dorsal region7.34
5.22
Nfatc4STRvStriatum ventral region3.62
2.21
Nfatc4THThalamus1.38
1.36
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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