AutismKB 2.0

Annotation Detail for NFIB


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Basic Information Top
Gene Symbol:NFIB ( HMGIC/NFIB,NFI-RED,NFIB2,NFIB3 )
Gene Full Name: nuclear factor I/B
Band: 9p23-p22.3
Quick LinksEntrez ID:4781; OMIM: 600728; Uniprot ID:NFIB_HUMAN; ENSEMBL ID: ENSG00000147862; HGNC ID: 7785
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus79 / 564012140
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma14 / 82823169
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma11 / 106883102
head and neck tumor12 / 13630288
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal212 / 336030763
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor33 / 125191263
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone10 / 71655139
bone marrow0 / 488010 
brain65 / 110098959
cervix5 / 48171103
connective tissue13 / 14925587
ear6 / 16212370
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye12 / 21105456
heart15 / 89626167
intestine2 / 2344728
kidney7 / 21177733
larynx2 / 2414582
liver4 / 20774319
lung37 / 336974109
lymph0 / 442700 
lymph node0 / 916100 
mammary gland15 / 15327197
mouth1 / 6705214
muscle4 / 10771537
nerve2 / 15768126
ovary4 / 10205139
pancreas2 / 2148129
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta12 / 28082542
prostate10 / 18934552
salivary gland3 / 20155148
skin6 / 21057428
spleen1 / 5395218
stomach3 / 9661931
testis2 / 3304426
thymus0 / 811310 
thyroid8 / 47473168
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord2 / 13680146
uterus40 / 232878171
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209289_at
Cell line Expression level Expression bar
721_B_lymphoblasts45.9
Adipocyte231.5
AdrenalCortex119.3
Adrenalgland51.95
Amygdala239.55
Appendix312.8
AtrioventricularNode40.3
BDCA4+_DentriticCells17.1
Bonemarrow25.6
BronchialEpithelialCells147.8
CD105+_Endothelial38.2
CD14+_Monocytes18.45
CD19+_BCells(neg._sel.)18.2
CD33+_Myeloid17.95
CD34+25.85
CD4+_Tcells15.4
CD56+_NKCells14.35
CD71+_EarlyErythroid25.6
CD8+_Tcells10.3
CardiacMyocytes334.25
Caudatenucleus25.8
Cerebellum210.75
CerebellumPeduncles160.65
CiliaryGanglion47.35
CingulateCortex259
Colorectaladenocarcinoma12.75
DorsalRootGanglion52.05
FetalThyroid238.25
Fetalbrain214.85
Fetalliver25.4
Fetallung53
GlobusPallidus82.3
Heart63
Hypothalamus41.2
Kidney49.7
Leukemia_chronicMyelogenousK-56215.9
Leukemia_promyelocytic-HL-6016.15
Leukemialymphoblastic(MOLT-4)12.25
Liver65.55
Lung116.1
Lymphnode38
Lymphoma_burkitts(Daudi)29.95
Lymphoma_burkitts(Raji)28.45
MedullaOblongata101.65
OccipitalLobe244.7
OlfactoryBulb151.25
Ovary85.3
Pancreas148.25
PancreaticIslet235.1
ParietalLobe173
Pituitary59.25
Placenta42.8
Pons46.4
PrefrontalCortex623
Prostate1192.65
Salivarygland339.4
SkeletalMuscle96.85
Skin305.05
SmoothMuscle740.25
Spinalcord25.2
SubthalamicNucleus91.1
SuperiorCervicalGanglion100.35
TemporalLobe137.75
Testis15.75
TestisGermCell127.15
TestisIntersitial36.4
TestisLeydigCell37.1
TestisSeminiferousTubule29.75
Thalamus24.5
Thymus110.8
Thyroid173.35
Tongue123.55
Tonsil37.3
Trachea526.4
TrigeminalGanglion61
Uterus730.25
UterusCorpus62.85
WholeBlood17.65
Wholebrain186.25
colon485.85
pineal_day94.6
pineal_night69.08
retina288
small_intestine484.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P658427
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.34 ± 0.16
Basal Forebrain9.16 ± 0.25
Basal Part of Pons9.05 ± 0.18
Cerebellar Cortex9.45 ± 0.23
Cerebellar Nuclei8.58 ± 0.3
Claustrum8.57 ± 0.36
Epithalamus9.31 ± 0.31
Frontal Lobe9.17 ± 0.3
Globus Pallidus9.23 ± 0.3
Hypothalamus8.78 ± 0.29
Insula9.52 ± 0.22
Limbic Lobe9.3 ± 0.25
Mesencephalon9.22 ± 0.35
Myelencephalon9.19 ± 0.35
Occipital Lobe9.03 ± 0.22
Parietal Lobe9.16 ± 0.22
Pontine Tegmentum9.13 ± 0.31
Striatum8.82 ± 0.25
Subthalamus8.77 ± 0.3
Temporal Lobe9.25 ± 0.24
Thalamus9.1 ± 0.28
White Matter8.5 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NfibCBCerebellum38.57
58.76
NfibCTXCerebral cortex58.5
44.85
NfibHIPHippocampal region72.01
91.19
NfibHPFHippocampal formation67.68
76.74
NfibHYHypothalamus4.15
2.65
NfibLSXLateral septal complex23.63
16.42
NfibMBMidbrain9.23
8.53
NfibMYMedulla24.94
25.5
NfibOLFOlfactory bulb68.32
55.82
NfibPPons27.32
27.31
NfibPALPallidum7.97
6.28
NfibRHPRetrohippocampal region59.66
51.34
NfibsAMYStriatum-like amygdalar nuclei12.92
10.31
NfibSTRStriatum12.2
10.05
NfibSTRdStriatum dorsal region9.88
9.1
NfibSTRvStriatum ventral region11.86
7.11
NfibTHThalamus4.75
4.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501977 18 318 335 KPEKPLFSSASPQDSSPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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