AutismKB 2.0

Annotation Detail for NFKB1


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Basic Information Top
Gene Symbol:NFKB1 ( DKFZp686C01211,EBP-1,KBF1,MGC54151,NF-kappa-B,NF-kappaB,NFKB-p105,NFKB-p50,p105,p50 )
Gene Full Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Band: 4q24
Quick LinksEntrez ID:4790; OMIM: 164011; Uniprot ID:NFKB1_HUMAN; ENSEMBL ID: ENSG00000109320; HGNC ID: 7794
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus21 / 56401237
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult103 / 193912153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor6 / 34366174
chondrosarcoma5 / 8282360
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor16 / 26384560
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor7 / 9635972
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal183 / 336030754
ovarian tumor1 / 7668213
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood17 / 123478137
bone6 / 7165583
bone marrow9 / 48801184
brain20 / 110098918
cervix6 / 48171124
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye8 / 21105437
heart2 / 8962622
intestine15 / 23447263
kidney10 / 21177747
larynx0 / 241450 
liver8 / 20774338
lung24 / 33697471
lymph3 / 4427067
lymph node12 / 91610130
mammary gland10 / 15327165
mouth4 / 6705259
muscle4 / 10771537
nerve4 / 15768253
ovary2 / 10205119
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta20 / 28082571
prostate7 / 18934536
salivary gland1 / 2015549
skin7 / 21057433
spleen7 / 53952129
stomach3 / 9661931
testis12 / 33044236
thymus9 / 81131110
thyroid4 / 4747384
tonsil2 / 16999117
trachea10 / 52413190
umbilical cord0 / 136800 
uterus16 / 23287868
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209239_at
Cell line Expression level Expression bar
721_B_lymphoblasts285.3
Adipocyte3.35
AdrenalCortex3.4
Adrenalgland2.75
Amygdala3.5
Appendix3.4
AtrioventricularNode2.5
BDCA4+_DentriticCells112.15
Bonemarrow3.25
BronchialEpithelialCells4.75
CD105+_Endothelial3.5
CD14+_Monocytes104.6
CD19+_BCells(neg._sel.)113.5
CD33+_Myeloid74.7
CD34+50.35
CD4+_Tcells147.7
CD56+_NKCells16.05
CD71+_EarlyErythroid3.1
CD8+_Tcells112.4
CardiacMyocytes4.45
Caudatenucleus2.95
Cerebellum2.7
CerebellumPeduncles3.7
CiliaryGanglion2.3
CingulateCortex3.35
Colorectaladenocarcinoma4.45
DorsalRootGanglion2.5
FetalThyroid3.75
Fetalbrain3.4
Fetalliver2.85
Fetallung3.6
GlobusPallidus2.35
Heart4.15
Hypothalamus3.65
Kidney2.65
Leukemia_chronicMyelogenousK-5623.05
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)2.7
Liver4.35
Lung4.45
Lymphnode3.95
Lymphoma_burkitts(Daudi)10.25
Lymphoma_burkitts(Raji)4.6
MedullaOblongata3.05
OccipitalLobe3
OlfactoryBulb2.6
Ovary2.3
Pancreas2.7
PancreaticIslet6.8
ParietalLobe3.55
Pituitary3.9
Placenta4.7
Pons3.7
PrefrontalCortex4.25
Prostate3.95
Salivarygland3.8
SkeletalMuscle3.7
Skin2.45
SmoothMuscle15.2
Spinalcord3.55
SubthalamicNucleus2.95
SuperiorCervicalGanglion3.7
TemporalLobe3
Testis2.9
TestisGermCell2.85
TestisIntersitial3
TestisLeydigCell3.25
TestisSeminiferousTubule2.9
Thalamus3.35
Thymus17.1
Thyroid4.5
Tongue3.2
Tonsil8
Trachea3.95
TrigeminalGanglion5
Uterus2.8
UterusCorpus3.25
WholeBlood23.6
Wholebrain2.85
colon3.4
pineal_day4.12
pineal_night4.1
retina4.125
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P30024
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.52 ± 0.63
Basal Forebrain6.02 ± 0.38
Basal Part of Pons6.15 ± 0.42
Cerebellar Cortex6.27 ± 0.23
Cerebellar Nuclei6 ± 0.48
Claustrum5.19 ± 0.63
Epithalamus5.81 ± 0.57
Frontal Lobe5.89 ± 0.38
Globus Pallidus6.14 ± 0.37
Hypothalamus5.89 ± 0.46
Insula5.82 ± 0.25
Limbic Lobe5.6 ± 0.4
Mesencephalon5.9 ± 0.37
Myelencephalon5.92 ± 0.44
Occipital Lobe6 ± 0.45
Parietal Lobe5.95 ± 0.41
Pontine Tegmentum5.84 ± 0.45
Striatum5.85 ± 0.5
Subthalamus6.16 ± 0.47
Temporal Lobe5.79 ± 0.38
Thalamus6.07 ± 0.39
White Matter7.02 ± 0.3
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NFKB1_HUMAN_214 16 214 229 LMFTAFLPDSTGSFTR PRIDE
PAp00009102 18 60 77 YVCEGPSHGGLPGASSEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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