AutismKB 2.0

Annotation Detail for NFRKB


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Basic Information Top
Gene Symbol:NFRKB ( DKFZp547B2013,INO80G )
Gene Full Name: nuclear factor related to kappaB binding protein
Band: 11q24.3
Quick LinksEntrez ID:4798; OMIM: 164013; Uniprot ID:NFRKB_HUMAN; ENSEMBL ID: ENSG00000170322; HGNC ID: 7802
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst5 / 6231980
fetus14 / 56401224
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor9 / 9635993
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal91 / 336030727
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer5 / 10268048
retinoblastoma3 / 4635664
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone5 / 7165569
bone marrow1 / 4880120
brain16 / 110098914
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye13 / 21105461
heart0 / 896260 
intestine10 / 23447242
kidney4 / 21177718
larynx0 / 241450 
liver12 / 20774357
lung16 / 33697447
lymph0 / 442700 
lymph node3 / 9161032
mammary gland4 / 15327126
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary3 / 10205129
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate9 / 18934547
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis18 / 33044254
thymus5 / 8113161
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213028_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.15
Adipocyte7.4
AdrenalCortex7.7
Adrenalgland6.4
Amygdala7.8
Appendix7.8
AtrioventricularNode5.6
BDCA4+_DentriticCells13.2
Bonemarrow7.6
BronchialEpithelialCells7.55
CD105+_Endothelial10.75
CD14+_Monocytes12.4
CD19+_BCells(neg._sel.)8.2
CD33+_Myeloid13.25
CD34+21.7
CD4+_Tcells21.7
CD56+_NKCells9.2
CD71+_EarlyErythroid10.75
CD8+_Tcells19.25
CardiacMyocytes10.25
Caudatenucleus7.05
Cerebellum6.15
CerebellumPeduncles8.45
CiliaryGanglion5
CingulateCortex7.75
Colorectaladenocarcinoma13.9
DorsalRootGanglion6.05
FetalThyroid7.75
Fetalbrain7.45
Fetalliver7.05
Fetallung6.2
GlobusPallidus5.55
Heart9.2
Hypothalamus7.85
Kidney6.2
Leukemia_chronicMyelogenousK-56211.05
Leukemia_promyelocytic-HL-608.85
Leukemialymphoblastic(MOLT-4)10.6
Liver9.9
Lung8.2
Lymphnode8.1
Lymphoma_burkitts(Daudi)12.55
Lymphoma_burkitts(Raji)12
MedullaOblongata6.8
OccipitalLobe6.8
OlfactoryBulb6
Ovary5.15
Pancreas6.25
PancreaticIslet8.2
ParietalLobe8.3
Pituitary9.05
Placenta8.75
Pons8.4
PrefrontalCortex9.35
Prostate8.75
Salivarygland6
SkeletalMuscle8.7
Skin5.8
SmoothMuscle8.75
Spinalcord7.9
SubthalamicNucleus6.6
SuperiorCervicalGanglion10.8
TemporalLobe6.9
Testis13.1
TestisGermCell12.8
TestisIntersitial10
TestisLeydigCell7.8
TestisSeminiferousTubule9.65
Thalamus7.6
Thymus7.05
Thyroid10.3
Tongue7.55
Tonsil7.75
Trachea7.2
TrigeminalGanglion8.7
Uterus6.2
UterusCorpus6.65
WholeBlood8.45
Wholebrain6.3
colon7.65
pineal_day9.56
pineal_night8.8
retina10.7
small_intestine7.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P24485
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.91 ± 0.98
Basal Forebrain2.24 ± 0.26
Basal Part of Pons2.21 ± 0.33
Cerebellar Cortex2.65 ± 0.52
Cerebellar Nuclei2.73 ± 0.7
Claustrum3.02 ± 0.77
Epithalamus2.22 ± 0.64
Frontal Lobe2.48 ± 0.7
Globus Pallidus2.36 ± 0.59
Hypothalamus2.48 ± 0.72
Insula2.22 ± 0.89
Limbic Lobe2.59 ± 0.61
Mesencephalon2.62 ± 0.73
Myelencephalon2.59 ± 0.67
Occipital Lobe2.58 ± 0.69
Parietal Lobe2.49 ± 0.71
Pontine Tegmentum2.58 ± 0.68
Striatum2.82 ± 0.79
Subthalamus2.55 ± 0.66
Temporal Lobe2.64 ± 0.7
Thalamus2.52 ± 0.64
White Matter2.16 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NfrkbCBCerebellum15.56
12.93
NfrkbCTXCerebral cortex75.74
30.85
NfrkbHIPHippocampal region48.17
41.02
NfrkbHPFHippocampal formation49.97
31.94
NfrkbHYHypothalamus31.4
9.72
NfrkbLSXLateral septal complex40.82
13.44
NfrkbMBMidbrain34.12
14.28
NfrkbMYMedulla41.06
20.44
NfrkbOLFOlfactory bulb66.55
32.51
NfrkbPPons40.16
18.06
NfrkbPALPallidum29.35
10.45
NfrkbRHPRetrohippocampal region53.35
20.91
NfrkbsAMYStriatum-like amygdalar nuclei33.39
9.86
NfrkbSTRStriatum39.54
13.09
NfrkbSTRdStriatum dorsal region39.75
13.48
NfrkbSTRvStriatum ventral region44.3
14.3
NfrkbTHThalamus30.84
12.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NFRKB_HUMAN_1060 13 1060 1072 LMPALGVSVADQK PRIDE
NFRKB_HUMAN_1075 15 1075 1089 STVASSEAKPAATIR PRIDE
NFRKB_HUMAN_1090 11 1090 1100 IVQGLGVMPPK PRIDE
NFRKB_HUMAN_1220 12 1220 1231 NIILTTMPAGTK PRIDE
NFRKB_HUMAN_1280 14 1280 1293 AVSTVVVTTAPSPK PRIDE
NFRKB_HUMAN_250 9 250 258 VELGDSDLK PRIDE
NFRKB_HUMAN_328 32 328 359 SEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIK PRIDE
NFRKB_HUMAN_489 15 489 503 QENEDSSDATTPVPR PRIDE
NFRKB_HUMAN_590 8 590 597 LPNGEGTR PRIDE
NFRKB_HUMAN_646 7 646 652 LWIYLHR PRIDE
NFRKB_HUMAN_746 11 746 756 SGPSTVSEPAK PRIDE
NFRKB_HUMAN_838 9 838 846 VPATATQTK PRIDE
NFRKB_HUMAN_983 7 983 989 SQVTTVK PRIDE
NFRKB_HUMAN_990 15 990 1004 LTQDLFGTGGNTTGK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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