AutismKB 2.0

Annotation Detail for NFX1


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Basic Information Top
Gene Symbol:NFX1 ( DKFZp779G2416,MGC20369,NFX2 )
Gene Full Name: nuclear transcription factor, X-box binding 1
Band: 9p12
Quick LinksEntrez ID:4799; OMIM: 603255; Uniprot ID:NFX1_HUMAN; ENSEMBL ID: ENSG00000086102; HGNC ID: 7803
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus52 / 56401292
neonate1 / 3109732
infant0 / 236200 
juvenile6 / 55556107
adult147 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor5 / 34366145
chondrosarcoma6 / 8282372
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor31 / 263845117
glioma9 / 10688384
head and neck tumor33 / 136302242
kidney tumor2 / 6895929
leukemia5 / 9584252
liver tumor5 / 9635951
lung tumor8 / 10312777
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal229 / 336030768
ovarian tumor3 / 7668239
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer8 / 10268077
retinoblastoma3 / 4635664
skin tumor10 / 12494980
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood6 / 12347848
bone4 / 7165555
bone marrow1 / 4880120
brain122 / 1100989110
cervix5 / 48171103
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus1 / 2020949
eye9 / 21105442
heart5 / 8962655
intestine13 / 23447255
kidney12 / 21177756
larynx6 / 24145248
liver8 / 20774338
lung20 / 33697459
lymph1 / 4427022
lymph node8 / 9161087
mammary gland8 / 15327152
mouth19 / 67052283
muscle3 / 10771527
nerve2 / 15768126
ovary3 / 10205129
pancreas5 / 21481223
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta20 / 28082571
prostate15 / 18934579
salivary gland0 / 201550 
skin12 / 21057456
spleen8 / 53952148
stomach2 / 9661920
testis48 / 330442145
thymus13 / 81131160
thyroid8 / 47473168
tonsil0 / 169990 
trachea14 / 52413267
umbilical cord0 / 136800 
uterus19 / 23287881
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202585_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.05
Adipocyte7.1
AdrenalCortex8.35
Adrenalgland6.25
Amygdala7.35
Appendix7.8
AtrioventricularNode7.95
BDCA4+_DentriticCells14.8
Bonemarrow8.4
BronchialEpithelialCells6.95
CD105+_Endothelial6.85
CD14+_Monocytes7.35
CD19+_BCells(neg._sel.)10.3
CD33+_Myeloid8.65
CD34+8.75
CD4+_Tcells8.3
CD56+_NKCells8.15
CD71+_EarlyErythroid7.2
CD8+_Tcells7
CardiacMyocytes9.2
Caudatenucleus6.5
Cerebellum6
CerebellumPeduncles8.5
CiliaryGanglion5.45
CingulateCortex7.45
Colorectaladenocarcinoma7.25
DorsalRootGanglion6.65
FetalThyroid7
Fetalbrain7.2
Fetalliver6.2
Fetallung5.7
GlobusPallidus5.3
Heart10.5
Hypothalamus7.55
Kidney6.2
Leukemia_chronicMyelogenousK-5626.5
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)5.8
Liver9.75
Lung7.7
Lymphnode7.1
Lymphoma_burkitts(Daudi)9.5
Lymphoma_burkitts(Raji)10.45
MedullaOblongata6.6
OccipitalLobe6.4
OlfactoryBulb5.7
Ovary5.25
Pancreas5.9
PancreaticIslet7.6
ParietalLobe7.75
Pituitary8.35
Placenta6.85
Pons7
PrefrontalCortex8.95
Prostate8.25
Salivarygland6.15
SkeletalMuscle10.85
Skin6.15
SmoothMuscle8
Spinalcord7.65
SubthalamicNucleus6.65
SuperiorCervicalGanglion9.4
TemporalLobe6.65
Testis6.15
TestisGermCell6.05
TestisIntersitial7
TestisLeydigCell7.7
TestisSeminiferousTubule6.6
Thalamus7.75
Thymus5.5
Thyroid9.2
Tongue7.25
Tonsil7.15
Trachea6
TrigeminalGanglion10.7
Uterus5.9
UterusCorpus6.9
WholeBlood7.75
Wholebrain5.95
colon7.2
pineal_day8.8
pineal_night8.42
retina8.975
small_intestine6.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P94683
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.09 ± 0.65
Basal Forebrain5.35 ± 0.27
Basal Part of Pons5.59 ± 0.26
Cerebellar Cortex5.81 ± 0.3
Cerebellar Nuclei5.08 ± 0.38
Claustrum4.59 ± 0.87
Epithalamus5.43 ± 0.31
Frontal Lobe5.3 ± 0.55
Globus Pallidus4.83 ± 0.43
Hypothalamus5.18 ± 0.53
Insula5.55 ± 0.28
Limbic Lobe5.05 ± 0.55
Mesencephalon5.39 ± 0.68
Myelencephalon5.23 ± 0.56
Occipital Lobe5.39 ± 0.36
Parietal Lobe5.24 ± 0.66
Pontine Tegmentum5.14 ± 0.45
Striatum5.14 ± 0.41
Subthalamus5.18 ± 0.36
Temporal Lobe5.3 ± 0.45
Thalamus5.32 ± 0.49
White Matter4.98 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nfx1CBCerebellum39.7
43.34
Nfx1CTXCerebral cortex100
81.47
Nfx1HIPHippocampal region73.79
100
Nfx1HPFHippocampal formation89.29
100
Nfx1HYHypothalamus88.14
70.26
Nfx1LSXLateral septal complex80.4
61.04
Nfx1MBMidbrain74.14
64.29
Nfx1MYMedulla71.27
80.35
Nfx1OLFOlfactory bulb83.68
75.52
Nfx1PPons66.17
71.14
Nfx1PALPallidum74.46
65.99
Nfx1RHPRetrohippocampal region100
100
Nfx1sAMYStriatum-like amygdalar nuclei100
94.5
Nfx1STRStriatum100
100
Nfx1STRdStriatum dorsal region100
100
Nfx1STRvStriatum ventral region100
100
Nfx1THThalamus90.26
76.11
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00502059 29 196 224 TTPKPEDAGPESTKPVGVFHPDSSEASSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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