AutismKB 2.0

Annotation Detail for NHP2L1


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Basic Information Top
Gene Symbol:NHP2L1 ( 15.5K,FA-1,FA1,NHPX,OTK27,SNRNP15-5,SNU13,SPAG12,SSFA1 )
Gene Full Name: NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Band: 22q13
Quick LinksEntrez ID:4809; OMIM: 601304; Uniprot ID:NH2L1_HUMAN; ENSEMBL ID: ENSG00000100138; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst15 / 62319240
fetus112 / 564012198
neonate1 / 3109732
infant23 / 23620973
juvenile8 / 55556143
adult287 / 1939121148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor13 / 94178138
cervical tumor5 / 34366145
chondrosarcoma11 / 82823132
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor23 / 119369192
germ cell tumor43 / 263845162
glioma30 / 106883280
head and neck tumor13 / 13630295
kidney tumor7 / 68959101
leukemia34 / 95842354
liver tumor35 / 96359363
lung tumor12 / 103127116
lymphoma14 / 71755195
non-neoplasia10 / 97250102
normal579 / 3360307172
ovarian tumor15 / 76682195
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS63 / 125680501
prostate cancer16 / 102680155
retinoblastoma11 / 46356237
skin tumor82 / 124949656
soft tissue/muscle tissue tumor24 / 125191191
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland7 / 33197210
ascites16 / 40015399
bladder3 / 29757100
blood43 / 123478348
bone6 / 7165583
bone marrow11 / 48801225
brain241 / 1100989218
cervix13 / 48171269
connective tissue17 / 149255113
ear5 / 16212308
embryonic tissue38 / 215722176
esophagus3 / 20209148
eye33 / 211054156
heart27 / 89626301
intestine31 / 234472132
kidney21 / 21177799
larynx6 / 24145248
liver48 / 207743231
lung60 / 336974178
lymph12 / 44270271
lymph node7 / 9161076
mammary gland28 / 153271182
mouth2 / 6705229
muscle12 / 107715111
nerve1 / 1576863
ovary21 / 102051205
pancreas28 / 214812130
parathyroid4 / 20539194
pharynx3 / 4132872
pituitary gland5 / 16585301
placenta39 / 280825138
prostate28 / 189345147
salivary gland3 / 20155148
skin98 / 210574465
spleen4 / 5395274
stomach19 / 96619196
testis35 / 330442105
thymus7 / 8113186
thyroid5 / 47473105
tonsil7 / 16999411
trachea0 / 524130 
umbilical cord0 / 136800 
uterus50 / 232878214
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201077_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts2066.55
Adipocyte304.9
AdrenalCortex507.15
Adrenalgland579.45
Amygdala395.45
Appendix95.4
AtrioventricularNode49.35
BDCA4+_DentriticCells1057.5
Bonemarrow350.2
BronchialEpithelialCells1146.8
CD105+_Endothelial1142.2
CD14+_Monocytes706.65
CD19+_BCells(neg._sel.)1196
CD33+_Myeloid740
CD34+1169.8
CD4+_Tcells688.4
CD56+_NKCells811.7
CD71+_EarlyErythroid419.35
CD8+_Tcells633.95
CardiacMyocytes622.95
Caudatenucleus254.25
Cerebellum382.45
CerebellumPeduncles401.9
CiliaryGanglion70.55
CingulateCortex289.45
Colorectaladenocarcinoma1106.15
DorsalRootGanglion128.85
FetalThyroid451.4
Fetalbrain277.95
Fetalliver210.8
Fetallung355.5
GlobusPallidus215.85
Heart1818.3
Hypothalamus531.15
Kidney256.65
Leukemia_chronicMyelogenousK-562656.25
Leukemia_promyelocytic-HL-60991.65
Leukemialymphoblastic(MOLT-4)737.85
Liver676.85
Lung661
Lymphnode334.95
Lymphoma_burkitts(Daudi)982.55
Lymphoma_burkitts(Raji)785.05
MedullaOblongata269.6
OccipitalLobe378.3
OlfactoryBulb215.7
Ovary282.35
Pancreas215.1
PancreaticIslet660
ParietalLobe343.8
Pituitary718.8
Placenta590.3
Pons255
PrefrontalCortex545.6
Prostate535.65
Salivarygland269.1
SkeletalMuscle171.35
Skin90.05
SmoothMuscle836.05
Spinalcord263.75
SubthalamicNucleus306.85
SuperiorCervicalGanglion103.55
TemporalLobe351
Testis1337.35
TestisGermCell832.05
TestisIntersitial1323.7
TestisLeydigCell756.35
TestisSeminiferousTubule938
Thalamus386.85
Thymus602.55
Thyroid434.5
Tongue213.55
Tonsil562.65
Trachea337.8
TrigeminalGanglion93.35
Uterus200.4
UterusCorpus157.75
WholeBlood386.4
Wholebrain564.1
colon288.95
pineal_day757.54
pineal_night785.6
retina576.275
small_intestine345.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P80362
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.82 ± 0.25
Basal Forebrain9.78 ± 0.16
Basal Part of Pons10.08 ± 0.21
Cerebellar Cortex9.75 ± 0.19
Cerebellar Nuclei10.09 ± 0.17
Claustrum9.66 ± 0.39
Epithalamus9.94 ± 0.13
Frontal Lobe10.06 ± 0.26
Globus Pallidus9.66 ± 0.43
Hypothalamus10.42 ± 0.19
Insula10.01 ± 0.24
Limbic Lobe9.73 ± 0.42
Mesencephalon9.95 ± 0.33
Myelencephalon9.83 ± 0.37
Occipital Lobe9.5 ± 0.35
Parietal Lobe9.92 ± 0.35
Pontine Tegmentum9.91 ± 0.36
Striatum9.64 ± 0.32
Subthalamus10.09 ± 0.33
Temporal Lobe9.98 ± 0.32
Thalamus9.76 ± 0.22
White Matter8.92 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nhp2l1CBCerebellum6.96
8.22
Nhp2l1CTXCerebral cortex48.35
39.37
Nhp2l1HIPHippocampal region38.33
45.83
Nhp2l1HPFHippocampal formation39.19
40.8
Nhp2l1HYHypothalamus36.52
31.31
Nhp2l1LSXLateral septal complex7.65
4.98
Nhp2l1MBMidbrain17.61
17.89
Nhp2l1MYMedulla9.69
14.28
Nhp2l1OLFOlfactory bulb44.34
39.11
Nhp2l1PPons18.49
24.16
Nhp2l1PALPallidum28.04
28.26
Nhp2l1RHPRetrohippocampal region43.14
34.02
Nhp2l1sAMYStriatum-like amygdalar nuclei30.24
24.05
Nhp2l1STRStriatum20.56
15.92
Nhp2l1STRdStriatum dorsal region14.63
11.19
Nhp2l1STRvStriatum ventral region37.75
27.95
Nhp2l1THThalamus23.71
21.74
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NH2L1_HUMAN_113 12 113 124 QQIQSIQQSIER PRIDE
NH2L1_HUMAN_114 12 114 125 QQIQSIQQSIER PRIDE
NH2L1_HUMAN_21 12 21 32 LLDLVQQSCNYK PRIDE
PAp00000213 16 92 107 ACGVSRPVIACSVTIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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