AutismKB 2.0

Annotation Detail for NKX3-1


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Basic Information Top
Gene Symbol:NKX3-1 ( BAPX2,NKX3,NKX3.1,NKX3A )
Gene Full Name: NK3 homeobox 1
Band: 8p21.2
Quick LinksEntrez ID:4824; OMIM: 602041; Uniprot ID:NKX31_HUMAN; ENSEMBL ID: ENSG00000167034; HGNC ID: 7838
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal55 / 336030716
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer33 / 102680321
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow1 / 4880120
brain1 / 11009890 
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate73 / 189345385
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis10 / 33044230
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211498_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte4.35
AdrenalCortex5.45
Adrenalgland4.1
Amygdala4.55
Appendix4.35
AtrioventricularNode4.2
BDCA4+_DentriticCells4.65
Bonemarrow4.45
BronchialEpithelialCells4.25
CD105+_Endothelial4.4
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.6
CD33+_Myeloid5.6
CD34+5.65
CD4+_Tcells4.65
CD56+_NKCells5.1
CD71+_EarlyErythroid4.15
CD8+_Tcells4.15
CardiacMyocytes5.35
Caudatenucleus3.95
Cerebellum3.55
CerebellumPeduncles5.55
CiliaryGanglion3.5
CingulateCortex4.6
Colorectaladenocarcinoma4.35
DorsalRootGanglion3.65
FetalThyroid4.2
Fetalbrain4.3
Fetalliver3.85
Fetallung3.55
GlobusPallidus3.45
Heart5.9
Hypothalamus4.7
Kidney3.95
Leukemia_chronicMyelogenousK-5623.95
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)3.5
Liver6
Lung4.8
Lymphnode3.7
Lymphoma_burkitts(Daudi)5.7
Lymphoma_burkitts(Raji)6.1
MedullaOblongata4.05
OccipitalLobe3.95
OlfactoryBulb3.45
Ovary2.95
Pancreas3.55
PancreaticIslet4.75
ParietalLobe4.8
Pituitary5.2
Placenta4.4
Pons4.35
PrefrontalCortex5.35
Prostate11.7
Salivarygland3.55
SkeletalMuscle5.35
Skin3.5
SmoothMuscle4.9
Spinalcord4.65
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.2
TemporalLobe4.15
Testis3.75
TestisGermCell3.6
TestisIntersitial3.65
TestisLeydigCell4.4
TestisSeminiferousTubule3.9
Thalamus4.6
Thymus3.4
Thyroid5.4
Tongue4.6
Tonsil4.25
Trachea3.65
TrigeminalGanglion5.35
Uterus3.5
UterusCorpus3.9
WholeBlood4.75
Wholebrain3.65
colon4.4
pineal_day5.44
pineal_night5.32
retina5.225
small_intestine4.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16764_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.01 ± 1.08
Basal Forebrain1.39 ± 0.22
Basal Part of Pons1.55 ± 0.6
Cerebellar Cortex1.51 ± 0.75
Cerebellar Nuclei1.91 ± 0.77
Claustrum2.56 ± 0.9
Epithalamus1.37 ± 0.7
Frontal Lobe1.52 ± 0.77
Globus Pallidus2.33 ± 0.66
Hypothalamus1.66 ± 0.92
Insula1.38 ± 0.65
Limbic Lobe1.7 ± 0.71
Mesencephalon1.8 ± 0.75
Myelencephalon1.69 ± 0.76
Occipital Lobe1.69 ± 0.86
Parietal Lobe1.64 ± 0.79
Pontine Tegmentum1.62 ± 0.75
Striatum1.85 ± 0.75
Subthalamus1.66 ± 0.65
Temporal Lobe1.52 ± 0.73
Thalamus1.56 ± 0.69
White Matter1.75 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nkx3-1CBCerebellum8.9
8.62
Nkx3-1CTXCerebral cortex4.68
2.12
Nkx3-1HIPHippocampal region1.64
0.99
Nkx3-1HPFHippocampal formation2.82
1.2
Nkx3-1HYHypothalamus1.08
0.57
Nkx3-1LSXLateral septal complex0.4
0.61
Nkx3-1MBMidbrain0.94
0.72
Nkx3-1MYMedulla3.84
2.15
Nkx3-1OLFOlfactory bulb9.67
5.74
Nkx3-1PPons1.55
0.69
Nkx3-1PALPallidum0.73
0.31
Nkx3-1RHPRetrohippocampal region4.92
1.55
Nkx3-1sAMYStriatum-like amygdalar nuclei0.62
0.38
Nkx3-1STRStriatum0.97
0.55
Nkx3-1STRdStriatum dorsal region0.96
0.52
Nkx3-1STRvStriatum ventral region1.56
0.74
Nkx3-1THThalamus0.99
0.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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