AutismKB 2.0

Annotation Detail for NMB


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Basic Information Top
Gene Symbol:NMB ( MGC17211,MGC2277,MGC3936 )
Gene Full Name: neuromedin B
Band: 15q25.2
Quick LinksEntrez ID:4828; OMIM: 162340; Uniprot ID:NMB_HUMAN; ENSEMBL ID: ENSG00000197696; HGNC ID: 7842
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma4 / 10688337
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal31 / 33603079
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain9 / 11009898
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye4 / 21105418
heart2 / 8962622
intestine1 / 2344724
kidney9 / 21177742
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach3 / 9661931
testis1 / 3304423
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205204_at
Cell line Expression level Expression bar
721_B_lymphoblasts23.55
Adipocyte139.2
AdrenalCortex56.95
Adrenalgland49.2
Amygdala47.65
Appendix44.9
AtrioventricularNode41.9
BDCA4+_DentriticCells31.1
Bonemarrow50.35
BronchialEpithelialCells37.5
CD105+_Endothelial41.95
CD14+_Monocytes34.65
CD19+_BCells(neg._sel.)35.55
CD33+_Myeloid50.95
CD34+57.45
CD4+_Tcells30.7
CD56+_NKCells55.3
CD71+_EarlyErythroid41.9
CD8+_Tcells19.95
CardiacMyocytes56.25
Caudatenucleus47.3
Cerebellum52.45
CerebellumPeduncles50.7
CiliaryGanglion48.3
CingulateCortex45.8
Colorectaladenocarcinoma44.9
DorsalRootGanglion59.85
FetalThyroid87.15
Fetalbrain45.6
Fetalliver38.4
Fetallung37.7
GlobusPallidus32.55
Heart56.1
Hypothalamus57.9
Kidney35.75
Leukemia_chronicMyelogenousK-56230.95
Leukemia_promyelocytic-HL-6035.25
Leukemialymphoblastic(MOLT-4)43.5
Liver58.35
Lung51.4
Lymphnode39.1
Lymphoma_burkitts(Daudi)56.85
Lymphoma_burkitts(Raji)61.95
MedullaOblongata41.5
OccipitalLobe40.45
OlfactoryBulb35.5
Ovary36
Pancreas36.05
PancreaticIslet106.3
ParietalLobe52.3
Pituitary52.95
Placenta46.9
Pons42.6
PrefrontalCortex42.75
Prostate53
Salivarygland44.45
SkeletalMuscle52.45
Skin37.85
SmoothMuscle51.15
Spinalcord70.05
SubthalamicNucleus40.8
SuperiorCervicalGanglion50.1
TemporalLobe40.85
Testis47.3
TestisGermCell37.65
TestisIntersitial46.7
TestisLeydigCell44.55
TestisSeminiferousTubule38.5
Thalamus50.1
Thymus35.35
Thyroid90.15
Tongue43.55
Tonsil43.75
Trachea37.45
TrigeminalGanglion47.95
Uterus33.3
UterusCorpus40.35
WholeBlood39.85
Wholebrain38.6
colon45
pineal_day59.82
pineal_night59.16
retina59.95
small_intestine43.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6928_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.29 ± 0.34
Basal Forebrain5.67 ± 0.36
Basal Part of Pons5.28 ± 0.47
Cerebellar Cortex5.61 ± 0.39
Cerebellar Nuclei5.32 ± 0.69
Claustrum5 ± 0.66
Epithalamus7.22 ± 0.46
Frontal Lobe5.76 ± 0.55
Globus Pallidus7.18 ± 0.47
Hypothalamus7.21 ± 0.97
Insula5.55 ± 0.2
Limbic Lobe5.56 ± 0.63
Mesencephalon6 ± 0.58
Myelencephalon5.8 ± 0.71
Occipital Lobe5.44 ± 0.62
Parietal Lobe5.56 ± 0.59
Pontine Tegmentum5.79 ± 0.75
Striatum5.82 ± 1
Subthalamus5.44 ± 0.42
Temporal Lobe5.74 ± 0.57
Thalamus5.79 ± 0.5
White Matter7.65 ± 1.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NmbCBCerebellum3.22
3.33
NmbCTXCerebral cortex6.27
4.06
NmbHIPHippocampal region4.52
4.76
NmbHPFHippocampal formation4.24
3.49
NmbHYHypothalamus3.97
2.59
NmbLSXLateral septal complex1.44
0.92
NmbMBMidbrain2.62
2.19
NmbMYMedulla6.77
5.61
NmbOLFOlfactory bulb29.75
43.76
NmbPPons6.96
7.1
NmbPALPallidum3.44
2.31
NmbRHPRetrohippocampal region4.08
2.02
NmbsAMYStriatum-like amygdalar nuclei4.03
2.45
NmbSTRStriatum2.48
1.59
NmbSTRdStriatum dorsal region1.81
1.21
NmbSTRvStriatum ventral region4.23
2.61
NmbTHThalamus3.3
2.19
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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