AutismKB 2.0

Annotation Detail for NME4


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Basic Information Top
Gene Symbol:NME4 ( NDPK-D,NM23H4,nm23-H4 )
Gene Full Name: non-metastatic cells 4, protein expressed in
Band: 16p13.3
Quick LinksEntrez ID:4833; OMIM: 601818; Uniprot ID:NDKM_HUMAN; ENSEMBL ID: ENSG00000103202; HGNC ID: 7852
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus36 / 56401263
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult187 / 193912196
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor22 / 94178233
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor9 / 26384534
glioma9 / 10688384
head and neck tumor11 / 13630280
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor6 / 9635962
lung tumor13 / 103127126
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal180 / 336030753
ovarian tumor3 / 7668239
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer26 / 102680253
retinoblastoma5 / 46356107
skin tumor14 / 124949112
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites4 / 4001599
bladder0 / 297570 
blood2 / 12347816
bone7 / 7165597
bone marrow1 / 4880120
brain38 / 110098934
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus1 / 2020949
eye14 / 21105466
heart7 / 8962678
intestine15 / 23447263
kidney6 / 21177728
larynx1 / 2414541
liver10 / 20774348
lung21 / 33697462
lymph0 / 442700 
lymph node2 / 9161021
mammary gland28 / 153271182
mouth4 / 6705259
muscle3 / 10771527
nerve1 / 1576863
ovary11 / 102051107
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate68 / 189345359
salivary gland2 / 2015599
skin21 / 21057499
spleen2 / 5395237
stomach6 / 9661962
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus17 / 23287872
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212739_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts896
Adipocyte441.55
AdrenalCortex182.65
Adrenalgland346.65
Amygdala84.8
Appendix131.35
AtrioventricularNode32.1
BDCA4+_DentriticCells105.8
Bonemarrow210.9
BronchialEpithelialCells389.75
CD105+_Endothelial1028.15
CD14+_Monocytes46.75
CD19+_BCells(neg._sel.)129.1
CD33+_Myeloid30.2
CD34+445.35
CD4+_Tcells70.7
CD56+_NKCells79.8
CD71+_EarlyErythroid1267.55
CD8+_Tcells59.5
CardiacMyocytes317.9
Caudatenucleus100.05
Cerebellum101.1
CerebellumPeduncles122.8
CiliaryGanglion19.45
CingulateCortex137.3
Colorectaladenocarcinoma258
DorsalRootGanglion49.85
FetalThyroid204.2
Fetalbrain96.2
Fetalliver376.95
Fetallung161.05
GlobusPallidus44.3
Heart468.5
Hypothalamus84.95
Kidney156.85
Leukemia_chronicMyelogenousK-562206.6
Leukemia_promyelocytic-HL-60332.6
Leukemialymphoblastic(MOLT-4)375.6
Liver1193.55
Lung317.6
Lymphnode80.4
Lymphoma_burkitts(Daudi)58.65
Lymphoma_burkitts(Raji)1042.2
MedullaOblongata63.05
OccipitalLobe54.65
OlfactoryBulb207.05
Ovary110
Pancreas52.25
PancreaticIslet66.7
ParietalLobe108.2
Pituitary189.75
Placenta75.9
Pons93.15
PrefrontalCortex159.15
Prostate1112.55
Salivarygland104.45
SkeletalMuscle81.8
Skin50.75
SmoothMuscle432.55
Spinalcord123.35
SubthalamicNucleus62.55
SuperiorCervicalGanglion35
TemporalLobe107.55
Testis103.4
TestisGermCell161.3
TestisIntersitial69.45
TestisLeydigCell112.85
TestisSeminiferousTubule108.35
Thalamus127.1
Thymus140.7
Thyroid426.2
Tongue45.1
Tonsil49.65
Trachea149.15
TrigeminalGanglion65.05
Uterus295.15
UterusCorpus148.15
WholeBlood86
Wholebrain87.45
colon104.75
pineal_day63.9
pineal_night57.22
retina239.7
small_intestine80.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16506_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.68 ± 0.51
Basal Forebrain7.53 ± 0.29
Basal Part of Pons7.46 ± 0.22
Cerebellar Cortex7.2 ± 0.25
Cerebellar Nuclei7.53 ± 0.36
Claustrum7.81 ± 0.42
Epithalamus7.02 ± 0.41
Frontal Lobe7.46 ± 0.39
Globus Pallidus8.08 ± 0.29
Hypothalamus7.54 ± 0.44
Insula7.43 ± 0.35
Limbic Lobe7.46 ± 0.41
Mesencephalon7.63 ± 0.43
Myelencephalon7.52 ± 0.39
Occipital Lobe7.35 ± 0.35
Parietal Lobe7.44 ± 0.39
Pontine Tegmentum7.39 ± 0.35
Striatum7.74 ± 0.47
Subthalamus7.26 ± 0.25
Temporal Lobe7.48 ± 0.41
Thalamus7.56 ± 0.3
White Matter7.24 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nme4STRdStriatum dorsal region40.66
30.21
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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