AutismKB 2.0

Annotation Detail for NOS2


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Basic Information Top
Gene Symbol:NOS2 ( HEP-NOS,INOS,NOS,NOS2A )
Gene Full Name: nitric oxide synthase 2, inducible
Band: 17q11.2
Quick LinksEntrez ID:4843; OMIM: 163730; Uniprot ID:NOS2_HUMAN; ENSEMBL ID: ENSG00000007171; HGNC ID: 7873
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal15 / 33603074
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine10 / 23447242
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210037_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.8
Adipocyte3.8
AdrenalCortex4
Adrenalgland3.2
Amygdala4.1
Appendix3.95
AtrioventricularNode3.1
BDCA4+_DentriticCells4.25
Bonemarrow3.75
BronchialEpithelialCells3.8
CD105+_Endothelial3.9
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)4.05
CD33+_Myeloid4.95
CD34+5.7
CD4+_Tcells4.25
CD56+_NKCells4.6
CD71+_EarlyErythroid4.9
CD8+_Tcells3.7
CardiacMyocytes5
Caudatenucleus3.45
Cerebellum3.1
CerebellumPeduncles4.3
CiliaryGanglion2.7
CingulateCortex3.85
Colorectaladenocarcinoma3.8
DorsalRootGanglion2.95
FetalThyroid3.7
Fetalbrain3.85
Fetalliver3.3
Fetallung3.2
GlobusPallidus2.85
Heart4.9
Hypothalamus4.15
Kidney3.1
Leukemia_chronicMyelogenousK-5623.45
Leukemia_promyelocytic-HL-603.4
Leukemialymphoblastic(MOLT-4)3.1
Liver5.05
Lung4.15
Lymphnode3.3
Lymphoma_burkitts(Daudi)4.9
Lymphoma_burkitts(Raji)5.35
MedullaOblongata3.5
OccipitalLobe3.45
OlfactoryBulb3
Ovary2.55
Pancreas3.05
PancreaticIslet4.05
ParietalLobe4.05
Pituitary4.5
Placenta4
Pons3.6
PrefrontalCortex4.8
Prostate4.45
Salivarygland3.05
SkeletalMuscle4.4
Skin2.95
SmoothMuscle4.35
Spinalcord4.1
SubthalamicNucleus3.45
SuperiorCervicalGanglion4.35
TemporalLobe3.5
Testis3.3
TestisGermCell3.25
TestisIntersitial3.2
TestisLeydigCell3.85
TestisSeminiferousTubule3.3
Thalamus3.9
Thymus3.05
Thyroid4.8
Tongue3.8
Tonsil3.7
Trachea3.2
TrigeminalGanglion3.8
Uterus3.1
UterusCorpus3.4
WholeBlood4.2
Wholebrain3.35
colon4.05
pineal_day4.8
pineal_night4.72
retina4.675
small_intestine3.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17040_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.25 ± 1.38
Basal Forebrain2.52 ± 0.25
Basal Part of Pons2.36 ± 0.33
Cerebellar Cortex2.36 ± 0.6
Cerebellar Nuclei2.85 ± 0.74
Claustrum3.02 ± 0.75
Epithalamus2.3 ± 0.85
Frontal Lobe2.92 ± 0.69
Globus Pallidus2.2 ± 0.7
Hypothalamus2.69 ± 0.62
Insula2.82 ± 0.7
Limbic Lobe2.47 ± 0.85
Mesencephalon2.92 ± 0.88
Myelencephalon2.76 ± 0.76
Occipital Lobe2.34 ± 0.81
Parietal Lobe3.2 ± 0.7
Pontine Tegmentum2.81 ± 0.67
Striatum1.93 ± 0.82
Subthalamus3 ± 0.9
Temporal Lobe2.98 ± 0.69
Thalamus2.59 ± 0.71
White Matter2.29 ± 0.57
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nos2CBCerebellum3.29
5.31
Nos2CTXCerebral cortex3.92
2.65
Nos2HIPHippocampal region1.74
1.83
Nos2HPFHippocampal formation1.34
1.29
Nos2HYHypothalamus2.68
1.93
Nos2LSXLateral septal complex2.44
1.49
Nos2MBMidbrain1.35
1.27
Nos2MYMedulla1.22
1.28
Nos2OLFOlfactory bulb9.63
7.14
Nos2PPons2.23
2.64
Nos2PALPallidum1.62
1.56
Nos2RHPRetrohippocampal region0.67
0.57
Nos2sAMYStriatum-like amygdalar nuclei1.25
1.32
Nos2STRStriatum2.21
2.19
Nos2STRdStriatum dorsal region1.95
2.55
Nos2STRvStriatum ventral region3.95
2.33
Nos2THThalamus2.51
2.09
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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