AutismKB 2.0

Annotation Detail for NOS3


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Basic Information Top
Gene Symbol:NOS3 ( ECNOS,eNOS )
Gene Full Name: nitric oxide synthase 3 (endothelial cell)
Band: 7q36.1
Quick LinksEntrez ID:4846; OMIM: 163729; Uniprot ID:NOS3_HUMAN; ENSEMBL ID: ENSG00000164867; HGNC ID: 7876
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult46 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor15 / 119369125
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal62 / 336030718
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites6 / 40015149
bladder0 / 297570 
blood4 / 12347832
bone1 / 7165513
bone marrow0 / 488010 
brain15 / 110098913
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine4 / 23447217
kidney4 / 21177718
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta18 / 28082564
prostate0 / 1893450 
salivary gland0 / 201550 
skin5 / 21057423
spleen9 / 53952166
stomach13 / 96619134
testis8 / 33044224
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205581_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.85
Adipocyte3.8
AdrenalCortex4
Adrenalgland3.2
Amygdala4
Appendix3.8
AtrioventricularNode2.9
BDCA4+_DentriticCells4.25
Bonemarrow3.7
BronchialEpithelialCells3.75
CD105+_Endothelial3.85
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)4.1
CD33+_Myeloid4.9
CD34+4.85
CD4+_Tcells4.15
CD56+_NKCells4.55
CD71+_EarlyErythroid3.55
CD8+_Tcells3.7
CardiacMyocytes4.8
Caudatenucleus3.4
Cerebellum3.05
CerebellumPeduncles4.3
CiliaryGanglion2.8
CingulateCortex3.85
Colorectaladenocarcinoma3.85
DorsalRootGanglion2.85
FetalThyroid3.7
Fetalbrain3.8
Fetalliver3.25
Fetallung3.15
GlobusPallidus2.75
Heart8.5
Hypothalamus4.15
Kidney3.1
Leukemia_chronicMyelogenousK-5623.5
Leukemia_promyelocytic-HL-603.4
Leukemialymphoblastic(MOLT-4)3.05
Liver5
Lung4.25
Lymphnode3.35
Lymphoma_burkitts(Daudi)4.8
Lymphoma_burkitts(Raji)6.25
MedullaOblongata3.5
OccipitalLobe3.45
OlfactoryBulb3
Ovary2.55
Pancreas3.05
PancreaticIslet4.05
ParietalLobe3.95
Pituitary4.45
Placenta13.25
Pons3.6
PrefrontalCortex4.8
Prostate4.5
Salivarygland3
SkeletalMuscle4.5
Skin2.9
SmoothMuscle4.35
Spinalcord4.05
SubthalamicNucleus3.4
SuperiorCervicalGanglion4.35
TemporalLobe3.45
Testis3.3
TestisGermCell3.4
TestisIntersitial3.25
TestisLeydigCell3.8
TestisSeminiferousTubule3.4
Thalamus3.9
Thymus3.05
Thyroid4.8
Tongue3.7
Tonsil3.7
Trachea3.2
TrigeminalGanglion4.3
Uterus3.2
UterusCorpus3.35
WholeBlood4.2
Wholebrain3.25
colon3.85
pineal_day4.78
pineal_night4.66
retina4.625
small_intestine3.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16594_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.33 ± 1.19
Basal Forebrain1.82 ± 0.15
Basal Part of Pons1.9 ± 0.73
Cerebellar Cortex1.89 ± 0.72
Cerebellar Nuclei2.13 ± 0.68
Claustrum2.79 ± 0.64
Epithalamus1.63 ± 1.04
Frontal Lobe1.84 ± 0.8
Globus Pallidus2.26 ± 0.74
Hypothalamus1.9 ± 0.8
Insula2.02 ± 0.89
Limbic Lobe1.99 ± 0.75
Mesencephalon2.06 ± 0.63
Myelencephalon2.08 ± 0.8
Occipital Lobe2.16 ± 0.82
Parietal Lobe1.95 ± 0.7
Pontine Tegmentum1.86 ± 0.71
Striatum2.19 ± 0.72
Subthalamus2.01 ± 0.79
Temporal Lobe1.84 ± 0.75
Thalamus1.96 ± 0.7
White Matter2 ± 0.32
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00763874 23 6 28 SVAQEPGPPCGLGLGLGLGLCGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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